Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation

American Journal of Hematology

Volumn 90, Issue 1, 2015, Pages 50-55

  Khera, Paramjit K ^a   Smith, Eric P ^a   Lindsell, Christopher J ^a   Rogge, Mary Colleen ^b   Haggerty, Shannon ^a   Wagner, David A ^c   Palascak, Mary B ^a   Mehta, Shilpa ^a   Hibbert, Jacqueline M ^d   Joiner, Clinton H ^e   Franco, Robert S ^a   Cohen, Robert M ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c METABOLIC SOLUTIONS INC   (United States)

^d MOREHOUSE SCHOOL OF MEDICINE   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE BLOOD LEVEL; GLYCINE; GLYCOSYLATED HEMOGLOBIN; HEME; HEMOGLOBIN A1C PROTEIN, HUMAN; NITROGEN;

ANALYSIS; BLOOD; CELL AGING; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS; ERYTHROCYTE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MALE; METABOLISM;

BLOOD GLUCOSE; CELL AGING; CELL SURVIVAL; DIABETES MELLITUS; ERYTHROCYTES; FEMALE; GLYCINE; HEME; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; NITROGEN ISOTOPES;

EID: 84919620692     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23866     Document Type: Article

References (40)

1. Nathan DM, Kuenen J, Borg R, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care 2008;31:1473-1478.
2. Ismail-Beigi F, Craven T, Banerji MA, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial. Lancet 2010;376:419-430.
3. Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008;359:1577-1589.
4. Nathan DM, Bayless M, Cleary P, et al. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: Advances and contributions. Diabetes 2013;62:3976-3986.
5. Cohen RM, Lindsell CJ. When the blood glucose and the HbA(1c) don't match: Turning uncertainty into opportunity. Diabetes Care 2012;35:2421-2423.
6. Bunn HF, Haney DN, Kamin S, et al. The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest 1976;57:1652-1659.
7. Virtue MA, Furne JK, Nuttall FQ, Levitt MD. Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration. Diabetes Care 2004;27:931-935.
8. Garlick RL, Mazer JS, Higgins PJ, Bunn HF. Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins. J Clin Invest 1983;71:1062-1072.
9. Smith RJ, Koenig RJ, Binnerts A, et al. Regulation of hemoglobin AIc formation in human erythrocytes in vitro. Effects of physiologic factors other than glucose. J Clin Invest 1982;69:1164-1168.
10. Rohlfing C, Wiedmeyer H-M, Little R, et al. Biological variation of glycohemoglobin. Clin Chem 2002;48:1116-1118.
11. Mohás M, Kisfali P, Baricza E, et al. A polymorphism within the fructosamine-3-kinase gene is associated with HbA1c Levels and the onset of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2010;118:209-212.
12. Cohen RM, Franco RS, Khera PK, et al. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood 2008;112:4284-4291.
13. Franco RS. Measurement of red cell lifespan and aging. Transfus Med Hemother 2012;39:302-307.
14. Berlin NI, Waldmann TA, Weissman SM. Life span of red blood cell. Physiol Rev 1959;39:577-616.
15. Herman WH, Cohen RM. Racial and ethnic differences in the relationship between HbA1c and blood glucose: Implications for the diagnosis of diabetes. J Clin Endocrinol Metab 2012;97:1-6.
16. Khera PK, Joiner CH, Carruthers A, et al. Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation. Diabetes 2008;57:2445-2452.
17. Cohen RM, Joiner CH, Franco RS. Discordant HbA1c results: The hoofbeats increase. J Pediatr 2008;153:7-9.
18. Franco RS. The measurement and importance of red cell survival. Am J Hematol 2009;84:109-114.
19. Mock DM, Lankford GL, Widness JA, et al. Measurement of red cell survival using biotin-labeled red cells: validation against 51Cr-labeled red cells. Transfusion 1999;39:156-162.
20. Franco RS, Lohmann J, Silberstein EB, et al. Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells. J Clin Invest 1998;101:2730-2740.
21. Hibbert JM, Sutherland GB, Wright LL, et al. Measurement of hemoglobin synthesis rate in vivo using a stable isotope method. Anal Biochem 2001;291:118-123.
22. Lindsell CJ, Franco RS, Smith EP, et al.: A method for the continuous calculation of the age of labeled red blood cells. Am J Hematol 2008;83:454-457.
23. Egyed A. A simple method for heme isolation. Experientia 1972;28:1396-1397.
24. 15N) labeling and continuous-flow isotope-ratio mass spectrometry as an alternative to radioactive labeling methods. J Clin Pharmacol 1993;33:246-252.
25. Lledó-García R, Kalicki RM, Uehlinger DE, Karlsson MO. Modeling of red blood cell life-spans in hematologically normal populations. J Pharmacokinet Pharmacodyn 2012;39:453-462.
26. Berlin NI, Hewitt C. Lotz C. Hippuric acid synthesis in man after the administration of [alpha-14C]Glycine. Biochem J 1954;58:498-503.
27. Carter MW, Matrone G. Mendenhall W. Estimation of the life span of red blood cells. J Gen Physiol 1964;47:851-858.
28. Shemin D, Rittenberg D. The life span of the human red blood cell. J Biol Chem 1946;166:627-636.
29. Bentley SA. Red cell survival studies reinterpreted. Clin Haematol 1977;6:601-623.
30. Peterson CM, Jones RL, Koenig RJ, et al. Reversible hematologic sequelae of diabetes mellitus. Ann Intern Med 1977;86:425-429.
31. Nuttall FQ, Gannon MC, Swaim WR, Adams MJ. Stability over time of glycohemoglobin, glucose, and red blood cell survival in hematologically stable people without diabetes. Metabolism 2004;53:1399-1404.
32. Rice L, Ruiz W, Driscoll T, et al. Neocytolysis on descent from altitude: A newly recognized mechanism for the control of red cell mass. Ann Intern Med 200;134:652-656.
33. Hibbert ÃJM, Creary ÃMS, Gee BE, et al. Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia. J Pediatr Gasteroenterol Nutr 2006;43:6880-6887.
34. Mock DM, Lankford GL, Widness JA, et al. RBCs labeled at two biotin densities permit simultaneous and repeated measures of circulating RBC volume. Transfusion 2004;44:431-437.
35. Aggarwal V, Schneider ALC, Selvin E. Low hemoglobin A(1c) in nondiabetic adults: An elevated risk state? Diabetes Care 2012;35:2055-2060.
36. Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358:2545-2559.
37. Standards of medical care in diabetes-2013. Diabetes Care 2013;36 (Suppl 1):S11-S66.
38. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009;32:1327-1334.
39. Saudek CD, Herman WH, Sacks DB, et al. A new look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab 2008;93:2447-2453.
40. Hare MJL, Magliano DJ, Zimmet PZ, et al. Glucose-independent ethnic differences in HbA1c in people without known diabetes. Diabetes Care 2013;36:1534-1540.