Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation

Diabetes

Volumn 57, Issue 9, 2008, Pages 2445-2452

  Khera, Paramjit K ^a   Joiner, Clinton H ^b   Carruthers, Anthony ^c   Lindsell, Christopher J ^a   Smith, Eric P ^a   Franco, Robert S ^a   Holmes, Yancey R ^a   Cohen, Robert M ^a,d  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSAMINE; GLITAZONE DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; SULFONYLUREA; 3' O METHYLGUANOSINE; 3'-O-METHYLGUANOSINE; CARBON; DIAGNOSTIC AGENT; DRUG DERIVATIVE; GLYCOSYLATED HEMOGLOBIN; GUANOSINE; UREA; WATER;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE MEMBRANE; FEMALE; GENETIC HETEROGENEITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCATION; GLYCEMIC CONTROL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MEAN CORPUSCULAR HEMOGLOBIN; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; BIOLOGICAL MODEL; DIABETES MELLITUS; ERYTHROCYTE; GLYCOSYLATION; HOMEOSTASIS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; RISK FACTOR;

ADULT; CARBON RADIOISOTOPES; DIABETES MELLITUS; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FEMALE; FRUCTOSAMINE; GLUCOSE; GLYCOSYLATION; GUANOSINE; HEMOGLOBIN A, GLYCOSYLATED; HOMEOSTASIS; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; RISK FACTORS; UREA; WATER;

EID: 52749091945     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1820     Document Type: Article

References (48)

1. Hempe JM, Gomez R, McCarterRJ, Jr, Chalew SA: High and low hemoglobin glycation phenotypes in type 1 diabetes: a challenge for interpretation of glycemic control. J Diabetes Complications 16:313-320, 2002
2. Yudkin JS, Forrest RD, Jackson CA, Ryle AJ, Davie S, Gould BJ: Unexplained variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Diabetologia 33:208-215, 1990
3. Gould BJ, Davie SJ, Yudkin JS: Investigation of the mechanism underlying the variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Clin Chim Acta 260:49-64, 1997
4. Cohen RM, Holmes YR, Chenier TC, Joiner CH: Discordance between A1C and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy. Diabetes Care 26:163-167, 2003
5. Cohen RM, LeCaire TJ, Lindsell CJ, Smith EP, D'Alessio DJ: The relationship of prospective glycated hemoglobin to glycated serum proteins in incident diabetic retinopathy: implications of the glycation gap for mechanism of risk prediction. Diabetes Care 31:151-153, 2007
6. 1c levels are genetically determined even in type 1 diabetes: evidence from healthy and diabetic twins. Diabetes 50:2858-2863, 2001
7. Cohen RM, Snieder H, Lindsell CJ, Beyan H, Hawa MI, Blinko S, Edwards R, Spector TD, Leslie RD: Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of A1C in nondiabetic twins. Diabetes Care 29:1739-1743, 2006
8. Higgins PJ, Garlick RL, Bunn HF: Glycosylated hemoglobin in human and animal red cells: role of glucose permeability. Diabetes 31:743-748, 1982
9. Cohen RM, Ciraolo P, Palascak MB, Lindsell CJ, Khera PK, Smith EP, Joiner CH, Franco RS: Red blood cell (RBC) survival differences among hematologically normal people with diabetes (DM) make a clinically important difference in A1C (Abstract). Diabetes 56 (Suppl. 1):A116, 2007
10. Carruthers A: Facilitated diffusion of glucose. Physiol Rev 70:1135-1176, 1990
11. Somogyi M: The distribution of sugar in blood. J Biol Chem 117-127, 1928
12. Chang H, Ewert SM, Bookchin RM, Nagel RL: Comparative evaluation of fifteen anti-sickling agents. Blood 61:693-704, 1983
13. Blodgett DM, Carruthers A: Quench-flow analysis reveals multiple phases of GluT1-mediated sugar transport. Biochemistry 44:2650-2660, 2005
14. Klepper J, Garcia-Alvarez M, O'Driscoll KR, Parides MK, Wang D, Ho YY, De Vivo DC: Erythrocyte 3-O-methyl-D-glucose uptake assay for diagnosis of glucose-transporter-protein syndrome. J Clin Lab Anal 13:116-121, 1999
15. Hamill S, Cloherty EK, Carruthers A: The human erythrocyte sugar transporter presents two sugar import sites. Biochemistry 38:16974-16983, 1999
16. Heard KS, Fidyk N, Carruthers A: ATP-dependent substrate occlusion by the human erythrocyte sugar transporter. Biochemistry 39:3005-3014, 2000
17. Carruthers A: ATP regulation of the human red cell sugar transporter. J Biol Chem 261:11028-11037, 1986
18. Cortes S, Gromova M, Evrard A, Roby C, Heyraud A, Rolin DB, Raymond P, Brouquisse RM: In plants, 3-o-methylglucose is phosphorylated by hexokinase but not perceived as a sugar. Plant Physiol 131:824-837, 2003
19. Malaisse-Lagae F, Giroix MH, Sener A, Malaisse WJ: Phosphorylation of 3-O-methyl-D-glucose by yeast and beef hexokinase. FEBS Lett 198:292-294, 1986
20. Gatley SJ, Holden JE, Halama JR, DeGrado TR, Bernstein DR, Ng CK: Phosphorylation of glucose analog 3-O-methyl-D-glucose by rat heart. Biochem Biophys Res Commun 119:1008-1014, 1984
21. Joiner CH, Lauf PK: Modulation of ouabain binding and potassium pump fluxes by cellular sodium and potassium in human and sheep erythrocytes. J Physiol 283:177-196, 1978
22. Bookchin RM, Balazs T, Lew VL: Measurement of the hemoglobin concentration in deoxyhemoglobin S polymers and characterization of the polymer water compartment. J Mol Biol 244:100-109, 1994
23. Levine KB, Robichaud TK, Hamill S, Sultzman LA, Carruthers A: Properties of the human erythrocyte glucose transport protein are determined by cellular context. Biochemistry 44:5606-5616, 2005
24. Rechthand E, Smith QR, Rapoport SI: Facilitated transport of glucose from blood into peripheral nerve. J Neurochem 45:957-964, 1985
25. Talley CP, Clayborn H, Jewel E, McCarty R, Gold PE: Vagotomy attenuates effects of L-glucose but not of D-glucose on spontaneous alternation performance. Physiol Behav 77:243-249, 2002
26. Cloherty EK, Heard KS, Carruthers A: Human erythrocyte sugar transport is incompatible with available carrier models. Biochemistry 35:10411-10421, 1996
27. Cloherty EK, Sultzman LA, Zottola RJ, Carruthers A: Net sugar transport is a multistep process: evidence for cytosolic sugar binding sites in erythrocytes. Biochemistry 34:15395-15406, 1995
28. Macleod J, Ponder E: Solvent water in the mammalian erythrocyte. J Physiol 86:147-152, 1936
29. Cook JS: Nonsolvent water in human erythrocytes. JGen Physiol 50:1311-1325, 1967
30. Lew VL, Hockaday A, Sepulveda MI, Somlyo AP, Somlyo AV, Ortiz OE, Bookchin RM: Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles. Nature 315:586-589, 1985
31. May JM: Ascorbate function and metabolism in the human erythrocyte. Front Biosci 3:d1-d10, 1998
32. Vera JC, Rivas CI, Fischbarg J, Golde DW: Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature 364: 79-82, 1993
33. Carruthers A: Anomalous asymmetric kinetics of human red cell hexose transfer: role of cytosolic adenosine 5'-triphosphate. Biochemistry 25: 3592-3602, 1986
34. Leitch JM, Carruthers A: ATP-dependent sugar transport complexity in human erythrocytes Am J Physiol Cell Physiol 292:C974-C986, 2007
35. Aubby DS, Widdas WF: Asymmetry of hexose transfer system in erythrocytes of fetal and new-born guinea-pigs. J Physiol 309:317-327, 1980
36. Stein WD: In Transport and Diffusion Across Cell Membranes. New York, Academic Press, 1986, p. 231-305
37. Concha II, Velasquez FV, Martinez JM, Angulo C, Droppelmann A, Reyes AM, Slebe JC, Vera JC, Golde DW: Human erythrocytes express GLUT5 and transport fructose. Blood 89:4190-4195, 1997
38. McCarter RJ, Hempe JM, Gomez R, Chalew SA: Biological variation in A1C predicts risk of retinopathy and nephropathy in type 1 diabetes. Diabetes Care 27:1259-1264, 2004
39. Chalew SA, McCarter RJ, Thomas J, Thomson JL, Hempe JM: A comparison of the glycosylation gap and hemoglobin glycation index in patients with diabetes. J Diabetes Complications 19:218-222, 2005
40. McCarter RJ, Hempe JM, Chalew SA: Mean blood glucose and biological variation have greater influence on A1C levels than glucose instability: an analysis of data from the Diabetes Control and Complications Trial. Diabetes Care 29:352-355, 2006
41. Lachin JM, Genuth S, Nathan DM, Rutledge BN: The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial. Diabetes 56:1913-1921, 2007
42. Genuth S, Lachin JM, Nathan DM: Biological variation in A1C predicts risk of retinopathy and nephropathy in type 1 diabetes: response to McCarter et al (Letter). Diabetes Care 28:233-235, 2005
43. Cohen RM: A1C: does one size fit all? Diabetes Care 30:2756-2758, 2007
44. Goodall I: A1C standardisation destination-global IFCC Standardisation. How, why, where and when-a tortuous pathway from kit manufacturers, via inter-laboratory lyophilized and whole blood comparisons to designated national comparison schemes. Clin Biochem Rev 26:5-19, 2005
45. Goldstein DE, Little RR, Lorenz RA, Malone JI, Nathan D, Peterson CM, Sacks DB: Tests of glycemia in diabetes. Diabetes Care 27:1761-1773, 2004
46. Nathan DM, Singer DE, Hurxthal K, Goodson JD: The clinical information value of the glycosylated hemoglobin assay. N Engl J Med 310:341-346, 1984
47. 1c in the Diabetes Control and Complications Trial. Diabetes Care 25:275-278, 2002
48. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus: the Diabetes Control and Complications Trial Research Group. N Engl J Med 329:977-986, 1993