A polymorphism within the fructosamine-3-kinase gene is associated with HbA1c levels and the onset of type 2 diabetes mellitus

Experimental and Clinical Endocrinology and Diabetes

Volumn 118, Issue 3, 2010, Pages 209-212

  Mohas M ^a   Kisfali, P ^a   Baricza, E ^a   Merei A ^a   Maasz A ^a   Cseh, J ^a   Mikolas E ^a   Szijarto I A ^a   Melegh, B ^a   Wittmann, I ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Diabetic microvascular complication; Fructosamine 3 kinase; HbA1c; Single nucleotide polymorphism

Indexed keywords

CELL ENZYME; FRUCTOSAMINE 3 KINASE; HEMOGLOBIN A1C; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROL GROUP; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; ENZYME ACTIVITY; FEMALE; FRUCTOSAMINE BLOOD LEVEL; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENETIC ASSOCIATION STUDIES; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77949505266     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1238319     Document Type: Article

References (11)

1. Conner JR, Beisswenger PJ, Szwergold BS. The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. Biochem Biophys Res Commun 2004 323 932-936
2. Delpierre G, Collard F, Fortpied J, etal. Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes. Biochem J 2002 365 801-808
3. Delpierre G, Veiga-da-Cunha M, Vertommen D, etal. Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites. Diabetes Metab 2006 32 31-39
4. Delpierre G, Vertommen D, Communi D, etal. Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin. J Biol Chem 2004 279 27613-27620
5. 1c in human blood. Clin Chem Lab Med 2002 40 78-89
6. Schmitt S, Linder M, Stndker L, etal. Identification of CML-modified proteins in hemofiltrate of diabetic patients by proteome analysis. Exp Clin Endocrinol Diabetes 2008 116 26-34
7. Stratmann B, Tschoepe D. Sweet heart contributions of metabolism in the development of heart failure in diabetes mellitus. Exp Clin Endocrinol Diabetes 2008 116 (Sl) S40-S45
8. Szwergold BS, Howell S, Beisswenger PJ. Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo. Diabetes 2001 50 2139-2147
9. Veiga da-Cunha M, Jacquemin P, Delpierre G, etal. Increased protein glycation in fructosamine 3-kinase-deficient mice. Biochem J 2006 399 257-264
10. Vlassara H, Bucala R, Striker L. Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging. Lab Invest 1994 70 138-151
11. Zietz B, Buechler C, Kobuch K, etal. Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes 2008 116 532-536