Discordant HbA1c Results: The Hoofbeats Increase

Journal of Pediatrics

Volumn 153, Issue 1, 2008, Pages 7-9

  Cohen, Robert M ^a   Joiner, Clinton H ^a   Franco, Robert S ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b Cincinnati Comprehensive Sickle Cell Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSAMINE; GLUCOSE; HEMOGLOBIN A1C; HEMOGLOBIN F; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN;

CLINICAL LABORATORY; EDITORIAL; ELECTROPHORESIS; GLUCOSE BLOOD LEVEL; GLYCATION; GLYCEMIC CONTROL; HEMOGLOBIN DETERMINATION; HEMOGLOBINOPATHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; LABORATORY TEST; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SURVIVAL TIME; BLOOD; BLOOD ANALYSIS; DIFFERENTIAL DIAGNOSIS; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; METHODOLOGY; NOTE;

BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DIAGNOSIS, DIFFERENTIAL; FRUCTOSAMINE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS;

EID: 47649125430     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2008.03.026     Document Type: Editorial

References (19)

1. Felner E.I., and McGrath M. Inaccurate HbA1c levels in patients with type 1 diabetes and hereditary persistence of hemoglobin F. J Pediatr 153 (2008) 137-139
2. Cohen M.P. Diabetes and Protein Glycosylation: Measurement and Biological Relevance (1986), Springer-Verlag, New York
3. Jeha G.S., and Haymond M. Understanding and interpreting laboratory test results in the clinical management of diabetes mellitus. Pediatr Endocrinol Rev 5 Suppl 1 (2007) 608-628
4. Cohen R.M., Holmes Y.R., Chenier T.C., and Joiner C.H. Discordance between hemoglobin A1c and fructosamine: evidence for a glycosylation gap and its relation to nephropathy in long-standing type 1 diabetes. Diabetes Care 26 (2003) 163-167
5. Cohen R.M. A1C: does one size fit all?. Diabetes Care 30 (2007) 2756-2758
6. Gould B.J., Davie S.J., and Yudkin J.S. Investigation of the mechanism underlying the variability of glycated haemoglobin in non-diabetic subjects not related to glycaemia. Clin Chim Acta 260 (1997) 49-64
7. McCarter R.J., Hempe J.M., Gomez R., and Chalew S.A. Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes. Diabetes Care 27 (2004) 1259-1264
8. Wilson D., Fiallo-Scharer R., Xing D., Wysocki T., Block J., Weinzimer S., et al. Diabetes Research in Children Network. Reliability of two indices of the biologic variabiity in glycosylation among children and adolescents with T1DM. [abstract]. Diabetes 54 Suppl 1 (2005) A454
9. Kim J.-I., Stevens R.J., and Holman R.R. The haemoglobin glycation index is an independent risk factor for microvascular complications in UKPDS patients with newly diagnosed type 2 diabetes. [abstract]. Diabetes 54 Suppl 1 (2005) A244
10. Lindsell C.J., Franco R.S., Smith E.P., Joiner C.H., and Cohen R.M. A method for the continuous calculation of the age of labeled red blood cells. Am J Hematol (2008) in press
11. Cohen R.M., Ciraolo P., Palascak M.B., Lindsell C.J., Khera P.K., Smith E.P., et al. Red blood cell (RBC) survival differences among hematologically normal people with diabetes (DM) make a clinically important difference in HbA1c. [abstract]. Diabetes 56 Suppl 1 (2007) A116
12. Cohen R.M., Lecaire T.J., Lindsell C.J., Smith E.P., and D'Alessio D.J. Relationship of prospective GHb to glycated serum proteins in incident diabetic retinopathy: implications of the glycation gap for mechanism of risk prediction. Diabetes Care 31 (2008) 151-153
13. Genuth S., Lachin J.M., and Nathan D.M. Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes: response to McCarter et al. Diabetes Care 28 (2005) 233-235
14. Chalew S.A., Hempe J.M., and McCarter R.J. Biological variation in HbA1c predicts risk of retinopathy and nephropathy in type 1 diabetes: response to Genuth, Lachin, and Nathan. Diabetes Care 28 (2005) 234-235
15. Lachin J.M., Genuth S., Nathan D.M., and Rutledge B.N. The hemoglobin glycation index is not an independent predictor of the risk of microvascular complications in the Diabetes Control and Complications Trial. Diabetes 56 (2007) 1913-1921
16. Khera P.K., Joiner C.H., Holmes Y.R., and Cohen R.M. Evidence for a steady-state glucose gradient across the erythrocyte membrane at 37°C: a potential source of variation in hemoglobin A1c. [abstract]. Diabetes 50 Suppl 2 (2001) A176
17. Snieder H., Sawtell P.A., Ross L., Walker J., Spector T.D., and Leslie R.D. HbA(1c) levels are genetically determined even in type 1 diabetes: evidence from healthy and diabetic twins. Diabetes 50 (2001) 2858-2863
18. Cohen R.M., Snieder H., Lindsell C.J., Beyan H., Hawa M., Blincko S., et al. Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in non-diabetic twins. Diabetes Care 29 (2006) 1739-1743
19. Herman W.H., Ma Y., Uwaifo G., Haffner S., Kahn S.E., Horton E.S., et al. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care 30 (2007) 2453-2457