-
1
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning BD, Cantley BD (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274. (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
2
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitation
-
Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitation. Nat Rev Cancer 9: 550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
4
-
-
84875648021
-
Phosphoinositide 3-kinase and INPP4B in human breast cancer
-
Bertucci MC, Mitchell CA (2013) Phosphoinositide 3-kinase and INPP4B in human breast cancer. Ann N Y Acad Sci 1280: 1-5.
-
(2013)
Ann N Y Acad Sci
, vol.1280
, pp. 1-5
-
-
Bertucci, M.C.1
Mitchell, C.A.2
-
5
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, et al. (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16: 115-125.
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
-
6
-
-
39149097499
-
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity
-
Ma K, Cheung SM, Marshall AJ, Duronio V (2008) PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cell Signal 20: 684-94.
-
(2008)
Cell Signal
, vol.20
, pp. 684-694
-
-
Ma, K.1
Cheung, S.M.2
Marshall, A.J.3
Duronio, V.4
-
7
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
DOI 10.1042/0264-6021:3440427
-
Navé BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR (1999) Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344 Pt 2: 427-31. (Pubitemid 30011599)
-
(1999)
Biochemical Journal
, vol.344
, Issue.2
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, D.M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
9
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3- kinase signaling
-
DOI 10.1016/S0304-419X(99)00032-3, PII S0304419X99000323
-
Vazquez F, Sellers WR (2000) The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 1470: M21-35. (Pubitemid 30070165)
-
(2000)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1470
, Issue.1
-
-
Vazquez, F.1
Sellers, W.R.2
-
10
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
Song MS, Salmena L, Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283-296.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
11
-
-
66149141021
-
PTEN and the PI3-kinase pathway in cancer
-
Chalhoub N, Baker SJ (2009) PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150.
-
(2009)
Annu Rev Pathol
, vol.4
, pp. 127-150
-
-
Chalhoub, N.1
Baker, S.J.2
-
12
-
-
51849111556
-
PI3K pathway alterations in cancer: Variation on a theme
-
Yuen TL, Cantley LC (2008) PI3K pathway alterations in cancer: variation on a theme. Oncogene, 27: 5497-5510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuen, T.L.1
Cantley, L.C.2
-
13
-
-
2442540470
-
Focus on nasopharyngeal carcinoma
-
DOI 10.1016/S1535-6108(04)00119-9, PII S1535610804001199
-
Lo KW, To KF, Huang DP (2004) Focus on nasopharyngeal Carcinoma. Cancer Cell, 5: 423-428. (Pubitemid 38612865)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 423-428
-
-
Lo, K.W.1
To, K.F.2
Huang, D.P.3
-
14
-
-
84857781938
-
Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches
-
Lo KW, Chung GT, To KF (2012) Deciphering the molecular genetic basis of NPC through molecular, cytogenetic, and epigenetic approaches. Semin Cancer Biol 22: 79-86.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 79-86
-
-
Lo, K.W.1
Chung, G.T.2
To, K.F.3
-
15
-
-
84862816141
-
The biology of EBV infection in human epithelial cells
-
Tsao SW, Tsang CM, Pang PS, Zhang G, Chen H, et al. (2012) The biology of EBV infection in human epithelial cells. Semin Cancer Biol 22: 137-143.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 137-143
-
-
Tsao, S.W.1
Tsang, C.M.2
Pang, P.S.3
Zhang, G.4
Chen, H.5
-
16
-
-
3442878123
-
Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma
-
DOI 10.1158/0008-5472.CAN-04-0538
-
Morrison JA, Gulley ML, Pathmanathan R, Raab-Traub N (2004) Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Res 64: 5251-5260. (Pubitemid 39006545)
-
(2004)
Cancer Research
, vol.64
, Issue.15
, pp. 5251-5260
-
-
Morrison, J.A.1
Gulley, M.L.2
Pathmanathan, R.3
Raab-Traub, N.4
-
17
-
-
0037423201
-
Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling
-
DOI 10.1074/jbc.M209840200
-
Dawson CW, Tramountanis G, Eliopoulos AG, Young LS (2003) Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 278: 3694-3704. (Pubitemid 36801094)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.6
, pp. 3694-3704
-
-
Dawson, C.W.1
Tramountanis, G.2
Eliopoulos, A.G.3
Young, L.S.4
-
18
-
-
34548156449
-
Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt pathway
-
DOI 10.1128/JVI.00537-07
-
Fukuda M, Longnecker R (2007) Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway. J Virol 81: 9299-9306. (Pubitemid 47311472)
-
(2007)
Journal of Virology
, vol.81
, Issue.17
, pp. 9299-9306
-
-
Fukuda, M.1
Longnecker, R.2
-
19
-
-
84885421975
-
Constitutive activation of distinct NF-κB signals in EBV-associated nasopharyngeal carcinoma
-
Chung GT, Lou WP, Chow C, To KF, Choy KW, et al. (2013) Constitutive activation of distinct NF-κB signals in EBV-associated nasopharyngeal carcinoma. J Pathol 231: 311-322.
-
(2013)
J Pathol
, vol.231
, pp. 311-322
-
-
Chung, G.T.1
Lou, W.P.2
Chow, C.3
To, K.F.4
Choy, K.W.5
-
20
-
-
73649128345
-
Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma
-
Or YY, Chung GT, To KF, Chow C, Choy KW, et al. (2010) Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma. J Pathol 220: 97-107.
-
(2010)
J Pathol
, vol.220
, pp. 97-107
-
-
Or, Y.Y.1
Chung, G.T.2
To, K.F.3
Chow, C.4
Choy, K.W.5
-
21
-
-
84857790848
-
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC)
-
Dawson CW, Port RJ, Young LS (2012) The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol 22: 144-153.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 144-153
-
-
Dawson, C.W.1
Port, R.J.2
Young, L.S.3
-
22
-
-
31544481905
-
PIK3CA mutations in nasopharyngeal carcinoma
-
Or YY, Hui AB, To KF, Lam CN, Lo KW (2006) PIK3CA mutations in nasopharyngeal carcinoma. Int J Cancer 118: 1065-1067.
-
(2006)
Int J Cancer
, vol.118
, pp. 1065-1067
-
-
Or, Y.Y.1
Hui, A.B.2
To, K.F.3
Lam, C.N.4
Lo, K.W.5
-
23
-
-
77954085990
-
PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival
-
Chou CC, Chou MJ, Tzen CY (2009) PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival. Med Oncol 26: 322-326.
-
(2009)
Med Oncol
, vol.26
, pp. 322-326
-
-
Chou, C.C.1
Chou, M.J.2
Tzen, C.Y.3
-
24
-
-
0032822527
-
Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus
-
DOI 10.1002/(SICI)1097-0215(19990924)83:1<121::AID
-
Cheung ST, Huang DP, Hui AB, Lo KW, Ko CW, et al. (1999) Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus. Int J Cancer 83: 121-126. (Pubitemid 29409487)
-
(1999)
International Journal of Cancer
, vol.83
, Issue.1
, pp. 121-126
-
-
Cheung, S.T.1
Huang, D.P.2
Hui, A.B.Y.3
Lo, K.W.4
Ko, C.W.5
Tsang, Y.S.6
Wong, N.7
Whitney, B.M.8
Lee, J.C.K.9
-
25
-
-
0018853340
-
Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx
-
Huang DP, Ho JH, Poon YF, Chew EC, Saw D, et al. (1980) Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx. Int J cancer 26: 127-132. (Pubitemid 10086410)
-
(1980)
International Journal of Cancer
, vol.26
, Issue.2
, pp. 127-132
-
-
Huang, D.P.1
Ho, J.H.C.2
Poon, Y.F.3
-
26
-
-
0037067180
-
Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
-
DOI 10.1016/S0167-4889(02)00208-2, PII S0167488902002082
-
Tsao SW, Wang X, Liu Y, Cheung YC, Feng H, et al. (2002) Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes. Biochim Biophys Acta 1590: 150-158. (Pubitemid 34626778)
-
(2002)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1590
, Issue.1-3
, pp. 150-158
-
-
Tsao, S.W.1
Wang, X.2
Liu, Y.3
Cheung, Y.C.4
Feng, H.5
Zheng, Z.6
Wong, N.7
Yuen, P.W.8
Lo, A.K.F.9
Wong, Y.C.10
Huang, D.P.11
-
27
-
-
2442482316
-
RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma
-
DOI 10.1002/ijc.20079
-
Chow LSN, Lo KW, Kwong J, Lam EC, To KF, et al. (2004) RASSF1A is a target tumor suppressor at chromosome region 3p21.3 in nasopharyngeal carcinoma. Int J Cancer 109: 839-847. (Pubitemid 38500740)
-
(2004)
International Journal of Cancer
, vol.109
, Issue.6
, pp. 839-847
-
-
Chow, L.S.-N.1
Lo, K.-W.2
Kwong, J.3
To, K.-F.4
Tsang, K.-S.5
Lam, C.-W.6
Dammann, R.7
Huang, D.P.8
-
28
-
-
33845473470
-
Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma
-
DOI 10.1002/gcc.20398
-
Kwong J. Chow LSN, Wong AYH, Hung WK, Chung GTY, et al. (2007) Epigenetic inactivation of deleted in lung and esophageal cancer 1 (DLEC1) gene in nasopharyngeal carcinoma. Genes Chromosomes Cancer 46: 171-180. (Pubitemid 44913382)
-
(2007)
Genes Chromosomes and Cancer
, vol.46
, Issue.2
, pp. 171-180
-
-
Kwong, J.1
Chow, L.S.-N.2
Wong, A.Y.-H.3
Hung, W.-K.4
Chung, G.T.-Y.5
To, K.-F.6
Chan, F.L.7
Daigo, Y.8
Nakamura, Y.9
Huang, D.P.10
Lo, K.-W.11
-
29
-
-
33745129384
-
Characterization of the murine Inpp4b gene and identification of a novel isoform
-
DOI 10.1016/j.gene.2006.02.022, PII S0378111906001843
-
Ferron M, Vacher J (2006) Characterization of the murine Inpp4b gene and identification of a novel isoform. Gene 376: 152-161. (Pubitemid 43903577)
-
(2006)
Gene
, vol.376
, Issue.1-2
, pp. 152-161
-
-
Ferron, M.1
Vacher, J.2
-
30
-
-
0035872408
-
High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma
-
Lo KW, Kwong J, Hui ABY, Chan SYY, To KF, et al. (2001) High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res 61: 3877-3881. (Pubitemid 32720944)
-
(2001)
Cancer Research
, vol.61
, Issue.10
, pp. 3877-3881
-
-
Lo, K.-W.1
Kwong, J.2
Hui, A.B.-Y.3
Chan, S.Y.-Y.4
To, K.-F.5
Chan, A.S.-C.6
Chow, L.S.-N.7
Teo, P.M.L.8
Johnson, P.J.9
Huang, D.P.10
-
31
-
-
0036152306
-
Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma
-
Kwong J, Lo KW, To KF, Teo PML, Johnson PJ, et al. (2002) Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin Cancer Res 8: 467-473.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 467-473
-
-
Kwong, J.1
Lo, K.W.2
To, K.F.3
Teo, P.M.L.4
Johnson, P.J.5
-
32
-
-
84886997326
-
FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma
-
Shu XS, Li L, Ji M, Cheng Y, Ying J, et al. (2013) FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma. Carcinogenesis 34: 1984-1993.
-
(2013)
Carcinogenesis
, vol.34
, pp. 1984-1993
-
-
Shu, X.S.1
Li, L.2
Ji, M.3
Cheng, Y.4
Ying, J.5
-
33
-
-
78650675585
-
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
-
Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, et al. (2010) Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci USA 107: 22231-22236.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 22231-22236
-
-
Fedele, C.G.1
Ooms, L.M.2
Ho, M.3
Vieusseux, J.4
O'Toole, S.A.5
-
34
-
-
78751535990
-
Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer
-
Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, et al. (2011) Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res 71: 572-582.
-
(2011)
Cancer Res
, vol.71
, pp. 572-582
-
-
Hodgson, M.C.1
Shao, L.J.2
Frolov, A.3
Li, R.4
Peterson, L.E.5
-
35
-
-
84900850019
-
A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms
-
Perez-Lorenzo R, Gill KZ, Shen CH, Zhao FX, Zheng B, et al. (2014) A tumor suppressor function for the lipid phosphatase INPP4B in melanocytic neoplasms. J Invest Dermatol, 134:1359-1368.
-
(2014)
J Invest Dermatol
, vol.134
, pp. 1359-1368
-
-
Perez-Lorenzo, R.1
Gill, K.Z.2
Shen, C.H.3
Zhao, F.X.4
Zheng, B.5
-
36
-
-
84873542829
-
MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN
-
Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, et al. (2013) MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis 34: 454-463.
-
(2013)
Carcinogenesis
, vol.34
, pp. 454-463
-
-
Zhang, L.Y.1
Ho-Fun Lee, V.2
Wong, A.M.3
Kwong, D.L.4
Zhu, Y.H.5
-
37
-
-
72849130207
-
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
-
Song LB, Li J, Liao WT, Feng Y, Yu CP, et al. (2009) The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 119: 3626-3636.
-
(2009)
J Clin Invest
, vol.119
, pp. 3626-3636
-
-
Song, L.B.1
Li, J.2
Liao, W.T.3
Feng, Y.4
Yu, C.P.5
|