BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy

Cell Reports

Volumn 6, Issue 6, 2014, Pages 973-981

  Brownlee, Peter M ^a   Chambers, Anna L ^a   Cloney, Ross ^a   Bianchi, Alessandro ^a   Downs, Jessica A ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAF180; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DNA; HIGH MOBILITY GROUP B PROTEIN; NUCLEAR PROTEIN; PBRM1 PROTEIN, HUMAN; PBRM1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL ADHESION; CENTROMERE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; TELOMERE; TRANSCRIPTION REGULATION; UPREGULATION; CELL FUNCTION; CELL LOSS; EMBRYO; MUTATIONAL ANALYSIS; PROTEIN FUNCTION; TUMOR CELL; YEAST CELL; ANIMAL; GENE EXPRESSION REGULATION; GENETICS;

ANEUPLOIDY; ANIMALS; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HMGB PROTEINS; HUMANS; MICE; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84897050302     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.02.012     Document Type: Article

References (30)

1. Angus-Hill M.L., Schlichter A., Roberts D., Erdjument-Bromage H., Tempst P., Cairns B.R. A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Mol. Cell 2001, 7:741-751.
2. Baetz K.K., Krogan N.J., Emili A., Greenblatt J., Hieter P. The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Mol. Cell. Biol. 2004, 24:1232-1244.
3. Barber T.D., McManus K., Yuen K.W., Reis M., Parmigiani G., Shen D., Barrett I., Nouhi Y., Spencer F., Markowitz S., et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc. Natl. Acad. Sci. USA 2008, 105:3443-3448.
4. Brough R., Bajrami I., Vatcheva R., Natrajan R., Reis-Filho J.S., Lord C.J., Ashworth A. APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. EMBO J. 2012, 31:1160-1176.
5. Brownlee P.M., Chambers A.L., Oliver A.W., Downs J.A. Cancer and the bromodomains of BAF180. Biochem. Soc. Trans. 2012, 40:364-369.
6. Burrows A.E., Smogorzewska A., Elledge S.J. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc. Natl. Acad. Sci. USA 2010, 107:14280-14285.
7. Canudas S., Smith S. Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J.Cell Biol. 2009, 187:165-173.
8. Carretero M., Ruiz-Torres M., Rodríguez-Corsino M., Barthelemy I., Losada A. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013, 32:2938-2949.
9. Chambers A.L., Brownlee P.M., Durley S.C., Beacham T., Kent N.A., Downs J.A. The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. PLoS ONE 2012, 7:e32016.
10. Chaumeil J., Augui S., Chow J.C., Heard E. Combined immunofluorescence, RNA fluorescent insitu hybridization, and DNA fluorescent insitu hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation. Methods Mol. Biol. 2008, 463:297-308.
11. Guo G., Sun X., Chen C., Wu S., Huang P., Li Z., Dean M., Huang Y., Jia W., Zhou Q., et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat. Genet. 2013, 45:1459-1463.
12. Holland A.J., Cleveland D.W. Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 2012, 13:501-514.
13. Huang J., Moazed D. Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev. 2003, 17:2162-2176.
14. Huang J., Hsu J.M., Laurent B.C. The RSC nucleosome-remodeling complex is required for Cohesin's association with chromosome arms. Mol. Cell 2004, 13:739-750.
15. Huang J., Brito I.L., Villén J., Gygi S.P., Amon A., Moazed D. Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 2006, 20:2887-2901.
16. Kong X., Ball A.R., Pham H.X., Zeng W., Chen H.Y., Schmiesing J.A., Kim J.S., Berns M., Yokomori K. Distinct functions of human cohesin-SA1 and cohesin-SA2 in DSB repair. Mol. Cell. Biol. 2014, 34:685-698.
17. Musio A., Montagna C., Zambroni D., Indino E., Barbieri O., Citti L., Villa A., Ried T., Vezzoni P. Inhibition of BUB1 results in genomic instability and anchorage-independent growth of normal human fibroblasts. Cancer Res. 2003, 63:2855-2863.
18. Natsume T., Müller C.A., Katou Y., Retkute R., Gierliński M., Araki H., Blow J.J., Shirahige K., Nieduszynski C.A., Tanaka T.U. Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol. Cell 2013, 50:661-674.
19. Oum J.H., Seong C., Kwon Y., Ji J.H., Sid A., Ramakrishnan S., Ira G., Malkova A., Sung P., Lee S.E., Shim E.Y. RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Mol. Cell. Biol. 2011, 31:3924-3937.
20. Remeseiro S., Cuadrado A., Carretero M., Martínez P., Drosopoulos W.C., Cañamero M., Schildkraut C.L., Blasco M.A., Losada A. Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J. 2012, 31:2076-2089.
21. Shain A.H., Pollack J.R. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS ONE 2013, 8:e55119.
22. Solomon D.A., Kim T., Diaz-Martinez L.A., Fair J., Elkahloun A.G., Harris B.T., Toretsky J.A., Rosenberg S.A., Shukla N., Ladanyi M., et al. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 2011, 333:1039-1043.
23. Solomon D.A., Kim J.S., Bondaruk J., Shariat S.F., Wang Z.F., Elkahloun A.G., Ozawa T., Gerard J., Zhuang D., Zhang S., et al. Frequent truncating mutations of STAG2 in bladder cancer. Nat. Genet. 2013, 45:1428-1430.
24. van der Lelij P., Godthelp B.C., van Zon W., van Gosliga D., Oostra A.B., Steltenpool J., de Groot J., Scheper R.J., Wolthuis R.M., Waisfisz Q., et al. The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2. PLoS ONE 2009, 4:e6936.
25. Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011, 469:539-542.
26. Vrouwe M.G., Elghalbzouri-Maghrani E., Meijers M., Schouten P., Godthelp B.C., Bhuiyan Z.A., Redeker E.J., Mannens M.M., Mullenders L.H., Pastink A., Darroudi F. Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair. Hum. Mol. Genet. 2007, 16:1478-1487.
27. Wang Z., Zhai W., Richardson J.A., Olson E.N., Meneses J.J., Firpo M.T., Kang C., Skarnes W.C., Tjian R. Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev. 2004, 18:3106-3116.
28. Xia W., Nagase S., Montia A.G., Kalachikov S.M., Keniry M., Su T., Memeo L., Hibshoosh H., Parsons R. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 2008, 68:1667-1674.
29. Xu H., Tomaszewski J.M., McKay M.J. Can corruption of chromosome cohesion create a conduit to cancer?. Nat. Rev. Cancer 2011, 11:199-210.
30. Xue Y., Canman J.C., Lee C.S., Nie Z., Yang D., Moreno G.T., Young M.K., Salmon E.D., Wang W. The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. Proc. Natl. Acad. Sci. USA 2000, 97:13015-13020.