Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus Pre-S2 mutant tumorigenesis

Journal of Virology

Volumn 89, Issue 1, 2015, Pages 605-614

  Teng, Chiao Fang ^a   Wu, Han Chieh ^a   Hsieh, Wen Chuan ^a   Tsai, Hung Wen ^b   Su, Ih Jen ^a,b,c  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACYL COENZYME A DESATURASE; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; CHOLESTEROL; FATTY ACID DESATURASE 2; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; HEPATITIS B SURFACE ANTIGEN; MTOR PROTEIN, MOUSE; MUTANT PROTEIN; PRESURFACE PROTEIN 2, HEPATITIS B SURFACE ANTIGEN; PROTEIN PRECURSOR; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TISSUE; CARCINOGENESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HISTONE ACETYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIPID METABOLISM; LIPID STORAGE; LIVER; LIVER CELL CARCINOMA; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PLASMID; PRE S2 MUTANT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION; VIRUS MUTANT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; GENE EXPRESSION PROFILING; GENETICS; HOST PATHOGEN INTERACTION; LIVER CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

HEPATITIS B VIRUS; MAMMALIA; MUS MUSCULUS;

ANIMALS; ATP CITRATE (PRO-S)-LYASE; CARCINOGENESIS; CELL LINE; GENE EXPRESSION PROFILING; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; LIPID METABOLISM; LIVER; MICE, TRANSGENIC; MUTANT PROTEINS; PROTEIN PRECURSORS; TOR SERINE-THREONINE KINASES;

EID: 84919429845     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02363-14     Document Type: Article

References (30)

1. Beasley RP, Hwang LY, Lin CC, Chien CS. 1981. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet ii:1129-1133.
2. Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG. 2012. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci USA 109:E2165-E2172. http://dx.doi.org/10.1073/pnas.1209182109.
3. Su IJ, Hsieh WC, Tsai HW, Wu HC. 2013. Chemoprevention and novel therapy for hepatocellular carcinoma associated with chronic hepatitis B virus infection. Hepatobiliary Surg Nutr 2:37-39. http://dx.doi.org/10.3978/j.issn.2304-3881.2012.10.08.
4. Wang HC, Huang W, Lai MD, Su IJ. 2006. Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci 97:683-688. http://dx.doi.org/10.1111/j.1349-7006.2006.00235.x.
5. Wang HC, Wu HC, Chen CF, Fausto N, Lei HY, Su IJ. 2003. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am J Pathol 163:2441-2449. http://dx.doi.org/10.1016/S0002-9440(10)63599-7.
6. Hsieh YH, Su IJ, Wang HC, Chang WW, Lei HY, Lai MD, Chang WT, Huang W. 2004. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 25:2023-2032. http://dx.doi.org/10.1093/carcin/bgh207.
7. Wang HC, Chang WT, Chang WW, Wu HC, Huang W, Lei HY, Lai MD, Fausto N, Su IJ. 2005. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 41:761-770. http://dx.doi.org/10.1002/hep.20615.
8. Su IJ, Wang HC, Wu HC, Huang WY. 2008. Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection. J Gastroenterol Hepatol 23:1169-1174. http://dx.doi.org/10.1111/j.1440-1746.2008.05348.x.
9. Pollicino T, Cacciola I, Saffioti F, Raimondo G. 2014. Hepatitis B virus PreS/S gene variants: pathobiology and clinical implications. J Hepatol 61:408-417. http://dx.doi.org/10.1016/j.jhep.2014.04.041.
10. Menendez JA, Lupu R. 2007. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7:763-777. http://dx.doi.org/10.1038/nrc2222.
11. Santos CR, Schulze A. 2012. Lipid metabolism in cancer. FEBS J 279: 2610-2623. http://dx.doi.org/10.1111/j.1742-4658.2012.08644.x.
12. Siegel AB, Zhu AX. 2009. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 115:5651-5661. http://dx.doi.org/10.1002/cncr.24687.
13. Patterson AD, Maurhofer O, Beyoglu D, Lanz C, Krausz KW, Pabst T, Gonzalez FJ, Dufour JF, Idle JR. 2011. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer Res 71:6590-6600. http://dx.doi.org/10.1158/0008-5472.CAN-11-0885.
14. Muir K, Hazim A, He Y, Peyressatre M, Kim DY, Song X, Beretta L. 2013. Proteomic and lipidomic signatures of lipid metabolism in NASHassociated hepatocellular carcinoma. Cancer Res 73:4722-4731. http://dx.doi.org/10.1158/0008-5472.CAN-12-3797.
15. Su TC, Lee YT, Cheng TJ, Chien HP, Wang JD. 2004. Chronic hepatitis B virus infection and dyslipidemia. J Formos Med Assoc 103:286-291.
16. Laplante M, Sabatini DM. 2009. mTOR signaling at a glance. J Cell Sci 122:3589-3594. http://dx.doi.org/10.1242/jcs.051011.
17. Laplante M, Sabatini DM. 2009. An emerging role of mTOR in lipid biosynthesis. Curr Biol 19:R1046-R1052. http://dx.doi.org/10.1016/j.cub.2009.09.058.
18. Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F. 2004. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86:839-848. http://dx.doi.org/10.1016/j.biochi.2004.09.018.
19. Yang JC, Teng CF, Wu HC, Tsai HW, Chuang HC, Tsai TF, Hsu YH, Huang W, Wu LW, Su IJ. 2009. Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology 49:1962-1971. http://dx.doi.org/10.1002/hep.22889.
20. Wang Z, Jin W, Jin H, Wang X. 2014. mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment. Biomed Res Int 2014:735672. http://dx.doi.org/10.1155/2014/735672.
21. Wu BK, Li CC, Chen HJ, Chang JL, Jeng KS, Chou CK, Hsu MT, Tsai TF. 2006. Blocking of G1/S transition and cell death in the regenerating liver of hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun 340:916-928. http://dx.doi.org/10.1016/j.bbrc.2005.12.089.
22. Culling CFA. 1974. Handbook of histopathological and histochemical techniques. Butterworth, London, United Kingdom.
23. Teng CF, Wu HC, Tsai HW, Shiah HS, Huang W, Su IJ. 2011. Novel feedback inhibition of surface antigen synthesis by mammalian target of rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and therapy. Hepatology 54:1199-1207. http://dx.doi.org/10.1002/hep.24529.
24. Zaidi N, Swinnen JV, Smans K. 2012. ATP-citrate lyase: a key player in cancer metabolism. Cancer Res 72:3709-3714. http://dx.doi.org/10.1158/0008-5472.CAN-11-4112.
25. Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y. 2008. ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer. Cancer Res 68:8547-8554. http://dx.doi.org/10.1158/0008-5472.CAN-08-1235.
26. Wu HC, Tsai HW, Teng CF, Hsieh WC, Lin YJ, Wang LH, Yuan Q, Su IJ. 2014. Ground-glass hepatocytes coexpressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis. Hum Pathol 45:1294-1301. http://dx.doi.org/10.1016/j.humpath.2013.10.039.
27. Hatzivassiliou G, Zhao F, Bauer DE, Andreadis C, Shaw AN, Dhanak D, Hingorani SR, Tuveson DA, Thompson CB. 2005. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8:311-321. http://dx.doi.org/10.1016/j.ccr.2005.09.008.
28. Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. 2009. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324:1076-1080. http://dx.doi.org/10.1126/science.1164097.
29. Nakamura MT, Nara TY. 2004. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 24:345-376. http://dx.doi.org/10.1146/annurev.nutr.24.121803.063211.
30. Gambarin-Gelwan M. 2013. Viral hepatitis, non-alcoholic fatty liver disease and alcohol as risk factors for hepatocellular carcinoma. Chin Clin Oncol 2:32. http://dx.doi.org/10.3978/j.issn.2304-3865.2013.09.02.