Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 8 PART1, 2008, Pages 1169-1174

  Su, Ih Jen ^a   Wang, Hui Ching ^a   Wu, Han Chieh ^a   Huang, Wen Ya ^b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Endoplasmic reticulum; Endoplasmic reticulum stress; Ground glass hepatocyte; Hepatocarcinogenesis; Pre S mutant

Indexed keywords

CYCLIN A; PROTEIN C JUN; PROTEIN P27; VIRUS PROTEIN;

DNA DAMAGE; ENDOPLASMIC RETICULUM; GENOMIC INSTABILITY; HEPATITIS B; HUMAN; LIVER CARCINOGENESIS; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINOBLASTOMA; REVIEW; SIGNAL TRANSDUCTION;

EID: 48549088872     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05348.x     Document Type: Review

References (49)

1. Hadziyannis S, Gerber MA, Vissoulis C, Popper H. Cytoplasmic hepatitis B antigen in 'ground-glass' hepatocytes of carriers. Arch. Pathol. 1973 96 : 327 30.
2. Popper H. The ground glass hepatocyte as a diagnostic hint. Hum Pathol 1975 6 : 517 20.
3. Shikata T. Australia antigen in liver tissue - an immunofluorescent and immunoelectron microscopic study. Jpn. J. Exp. Med. 1973 43 : 231 45.
4. Shikata T, Uzawa T, Yoshiwara N, Akatsuka T, Yamazaki S. Staining methods of Australia antigen in paraffin section - detection of cytoplasmic inclusion bodies. Jpn. J. Exp. Med. 1974 44 : 25 36.
5. Gudat F, Bianchi L, Sonnabend W, Thiel G, Aenishaenslin W, Stalder GA. Pattern of core and surface expression in liver tissue reflects state of specific immune response in hepatitis B. Lab. Invest. 1975 32 : 1 9.
6. Hsu HC, Lai MY, Su IJ et al. Correlation of hepatocyte HBsAg expression with virus replication and liver pathology. Hepatology 1988 8 : 749 54.
7. Wang HC, Wu HC, Chen CF, Fausto N, Lei HY, Su IJ. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am. J. Pathol 2003 163 : 2441 9.
8. Su IJ, Kuo TT, Liaw YF. Hepatocyte hepatitis B surface antigen. Diagnostic evaluation of patients with clinically acute hepatitis B surface antigen-positive hepatitis. Arch. Pathol. Lab. Med. 1985 109 : 400 2.
9. Hsu HC, Lin YH, Chang MH, Su IJ, Chen DS. Pathology of chronic hepatitis B virus infection in children: with special reference to the intrahepatic expression of hepatitis B virus antigens. Hepatology 1988 8 : 378 82.
10. Su IJ, Lai MY, Hsu HC et al. Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. J. Hepatol. 1986 3 : 182 9.
11. Fan YF, Lu CC, Chang YC et al. Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection. J. Gastroenterol. Hepatol. 2000 15 : 519 28.
12. Tai PC, Banik D, Lin GI et al. Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen. J. Virol. 1997 71 : 4852 6.
13. Hsu HC, Wu TT, Wu MZ et al. Evolution of expression of hepatitis B surface and core antigens (HBsAg, HBcAg) in resected primary and recurrent hepatocellular carcinoma in HBsAg carriers in Taiwan. Correlation with local host immune response. Cancer 1988 62 : 915 21.
14. Lu CC, Yen TS. Activation of the hepatitis B virus S promoter by transcription factor NF-Y via a CCAAT element. Virology 1996 225 : 387 94.
15. Huang TJ, Lu CC, Tsai JC et al. Novel autoregulatory function of hepatitis B virus M protein on surface gene expression. J. Biol. Chem. 2005 280 : 27742 54.
16. Bruss V, Lu X, Thomssen R, Gerlich WH. Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein. EMBO J. 1994 13 : 2273 9.
17. Ostapchuk P, Hearing P, Ganem D. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J. 1994 13 : 1048 57.
18. Loffler-Mary H, Werr M, Prange R. Sequence-specific repression of cotranslational translocation of the hepatitis B virus envelope proteins coincides with binding of heat shock protein Hsc70. Virology 1997 235 : 144 52.
19. Hildt E, Hofschneider PH. The PreS2 activators of the hepatitis B virus: activators of tumour promoter pathways. Recent Results Cancer Res. 1998 154 : 315 29.
20. Hildt E, Urban S, Eckerskorn C, Hofschneider PH. Isolation of highly purified, functional carboxy-terminally truncated hepatitis B virus middle surface protein activators from eucaryotic expression systems. Hepatology 1996 24 : 502 7.
21. Klingmuller U, Schaller H. Hepadnavirus infection requires interaction between the viral pre-S domain and a specific hepatocellular receptor. J. Virol. 1993 67 : 7414 22.
22. Neurath AR, Kent SB, Strick N, Parker K. Identification and chemical synthesis of a host cell receptor binding site on hepatitis B virus. Cell 1986 46 : 429 36.
23. Xu Z, Yen TS. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J. Virol. 1996 70 : 133 40.
24. Melegari M, Bruno S, Wands JR. Properties of hepatitis B virus pre-S1 deletion mutants. Virology 1994 199 : 292 300.
25. Bock CT, Tillmann HL, Maschek HJ, Manns MP, Trautwein C. A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly. Gastroenterology 1997 113 : 1976 82.
26. Pult I, Chouard T, Wieland S, Klemenz R, Yaniv M, Blum HE. A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. Hepatology 1997 25 : 1507 15.
27. Santantonio T, Jung MC, Schneider R et al. Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy. Virology 1992 188 : 948 52.
28. Marx J. Cell biology. A stressful situation. Science 2006 313 : 1564 6.
29. Hung JH, Su IJ, Lei HY et al. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J. Biolog Chem. 2004 279 : 46384 92.
30. Hsieh YH, Su IJ, Wang HC et al. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis 2004 25 : 2023 32.
31. Wang HC, Chang WT, Chang WW et al. Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology 2005 41 : 761 70.
32. Hsieh YH, Su IJ, Wang HC et al. Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1. Mol. Cancer Res. 2007 5 : 1063 72.
33. Lee EW, Oh W, Song J. Jab1 as a mediator of nuclear export and cytoplasmic degradation of p53. Mol. Cells 2006 22 : 133 40.
34. Schwechheimer C. The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Biochim. Biophys. Acta 2004 1695 : 45 54.
35. Gunther S, Fischer L, Pult I, Sterneck M, Will H. Naturally occurring variants of hepatitis B virus. Adv. Virus Res. 1999 52 : 25 137.
36. Fernholz D, Galle PR, Stemler M, Brunetto M, Bonino F, Will H. Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier. Virology 1993 194 : 137 48.
37. Le Seyec J, Chouteau P, Cannie I, Guguen-Guillouzo C, Gripon P. Role of the pre-S2 domain of the large envelope protein in hepatitis B virus assembly and infectivity. J. Virol. 1998 72 : 5573 8.
38. Fan YF, Lu CC, Chen WC et al. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001 33 : 277 86.
39. Huy TT, Ushijima H, Win KM et al. High prevalence of hepatitis B virus pre-s mutant in countries where it is endemic and its relationship with genotype and chronicity. J. Clin. Microbiol. 2003 41 : 5449 55.
40. Huy TT, Abe K. Molecular epidemiology of hepatitis B and C virus infections in Asia. Pediatr. Int. 2004 46 : 223 30.
41. Chen BF, Liu CJ, Jow GM, Chen PJ, Kao JH, Chen DS. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology 2006 130 : 1153 68.
42. Lin CL, Liu CH, Chen W et al. Association of pre-S deletion mutant of hepatitis B virus with risk of hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2007 22 : 1098 103.
43. Lauer U, Weiss L, Hofschneider PH, Kekule AS. The hepatitis B virus pre-S/S (t) transactivator is generated by 3′ truncations within a defined region of the S gene. J. Virol. 1992 66 : 5284 9.
44. Meyer M, Wiedorn KH, Hofschneider PH, Koshy R, Caselmann WH. A chromosome 17:7 translocation is associated with a hepatitis B virus DNA integration in human hepatocellular carcinoma DNA. Hepatology 1992 15 : 665 71.
45. Akbar SK, Onji M. Hepatitis B virus (HBV) -transgenic mice as an investigative tool to study immunopathology during HBV infection. Int. J. Exp. Pathol. 1998 79 : 279 91.
46. Huang SN, Chisari FV. Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology 1995 21 : 620 6.
47. Hagen TM, Huang S, Curnutte J et al. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 1994 91 : 12808 12.
48. Wang HC, Huang W, Lai MD, Su IJ. Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci. 2006 97 : 683 8.
49. Zheng Y, Chen WL, Louie SG, Yen TS, Ou JH. Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 2007 45 : 16 21.