Non-invasive imaging of microcirculation: A technology review

Medical Devices: Evidence and Research

Volumn 7, Issue , 2014, Pages 445-452

  Eriksson, Sam ^a,b   Nilsson, Jan ^a,b   Sturesson, Christian ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Laser Doppler imaging; Laser speckle contrast imaging; Orthogonal polarization spectral imaging; Sidestream dark field

Indexed keywords

CLASSIFIERS; DOPPLER EFFECT; LASER DOPPLER VELOCIMETERS; MICROCIRCULATION; NONINVASIVE MEDICAL PROCEDURES; POLARIZATION; SPECTROSCOPY;

DARK-FIELD; LASER DOPPLER IMAGING; LASER DOPPLER PERFUSION IMAGING; LASER SPECKLE CONTRAST IMAGING; NONCONTACT MEASUREMENTS; ORTHOGONAL POLARIZATIONS; PHYSIOLOGICAL PROCESS; SPECTRAL IMAGING;

SPECKLE;

HEMOGLOBIN;

ARTICLE; ARTIFACT; AUTOMATION; BLOOD FLOW; CAMERA; CLINICAL EFFECTIVENESS; CONTRAST RADIOGRAPHY; DARK FIELD MICROSCOPE; EQUIPMENT DESIGN; ERYTHROCYTE; HUMAN; IMAGE QUALITY; IMAGE RECONSTRUCTION; IMAGING SOFTWARE; IMAGING SYSTEM; INTERMETHOD COMPARISON; LASER DOPPLER FLOWMETRY; LASER SPECKLE CONTRAST IMAGING; MICROCIRCULATION; NON INVASIVE PROCEDURE; PROCESS CONTROL; PROCESS DESIGN; PROCESS MODEL; PROCESS OPTIMIZATION; PROCESS TECHNOLOGY; SENSITIVITY ANALYSIS; SIGNAL PROCESSING; TISSUE OXYGENATION; TISSUE PERFUSION; VIDEO MICROSCOPY;

EID: 84919417424     PISSN: None     EISSN: 11791470     Source Type: Journal    
DOI: 10.2147/MDER.S51426     Document Type: Article

References (70)

1. Roustit M, Cracowski JL. Assessment of endothelial and neurovascular function in human skin microcirculation. Trends Pharmacol Sci. 2013;34(7):373–384.
2. Rizzoni D, Aalkjaer C, De Ciuceis C, et al. How to assess microvascular structure in humans. High Blood Press Cardiovasc Prev. 2011;18(4): 169–177.
3. De Backer D, Hollenberg S, Boerma C, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007;11(5):R101.
4. Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends Pharmacol Sci. 2006;27(9):503–508.
5. Roustit M, Millet C, Blaise S, Dufournet B, Cracowski JL. Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity. Microvasc Res. 2010;80(3):505–511.
6. Bezemer R, Legrand M, Klijn E, et al. Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. Opt Express. 2010;18(14):15054–15061.
7. De Ciuceis C, Porteri E, Rizzoni D, et al. Structural alterations of subcutaneous small-resistance arteries may predict major cardiovascular events in patients with hypertension. Am J Hypertens. 2007;20(8):846–852.
8. Grassi G, Seravalle G, Scopelliti F, et al. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity (Silver Spring). 2010;18(1):92–98.
9. Rossi M, Matteucci E, Pesce M, et al. Peripheral microvascular dysfunction as an independent predictor of atherosclerotic damage in type 1 diabetes patients: a preliminary study. Clin Hemorheol Microcirc. 2013;54(4):381–391.
10. Sherman H, Klausner S, Cook WA. Incident dark-field illumination: a new method for microcirculatory study. Angiology. 1971;22(5): 295–303.
11. Groner W, Winkelman JW, Harris AG, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med. 1999;5(10):1209–1212.
12. Biberthaler P, Langer S, Luchting B, Khandoga A, Messmer K. In vivo assessment of colon microcirculation: comparison of the new OPS imaging technique with intravital microscopy. Eur J Med Res. 2001;6(12):525–534.
13. Mathura KR, Vollebregt KC, Boer K, De Graaff JC, Ubbink DT, Ince C. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol (1985). 2001;91(1):74–78.
14. Harris AG, Sinitsina I, Messmer K. Validation of OPS imaging for microvascular measurements during isovolumic hemodilution and low hematocrits. Am J Physiol Heart Circ Physiol. 2002;282(4):H1502–H1509.
15. Ince C. Sidestream dark field imaging: an improved technique to observe sublingual microcirculation. Crit Care. 2005;9(Suppl 1):72.
16. Goedhart PT, Khalilzada M, Bezemer R, Merza J, Ince C. Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express. 2007;15(23):15101–15114.
17. MicroVisionMedical [homepage on the Internet]. Available from: http://www.microvisionmedical.com/. Accessed June 1, 2013.
18. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166(1):98–104.
19. Paize F, Sarginson R, Makwana N, et al. Changes in the sublingual microcirculation and endothelial adhesion molecules during the course of severe meningococcal disease treated in the paediatric intensive care unit. Intensive Care Med. 2012;38(5):863–871.
20. Lupi O, Semenovitch I, Treu C, Bouskela E. Orthogonal polarization technique in the assessment of human skin microcirculation. Int J Dermatol. 2008;47(5):425–431.
21. Lindeboom JA, Mathura KR, Harkisoen S, van den Akker HP, Ince C. Effect of smoking on the gingival capillary density: assessment of gingival capillary density with orthogonal polarization spectral imaging. J Clin Periodontol. 2005;32(12):1208–1212.
22. Schaser KD, Settmacher U, Puhl G, et al. Noninvasive analysis of conjunctival microcirculation during carotid artery surgery reveals microvascular evidence of collateral compensation and stenosis-dependent adaptation. J Vasc Surg. 2003;37(4):789–797.
23. Pennings FA, Ince C, Bouma GJ. Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging. Neurosurgery. 2006;59(1):167–171.
24. den Uil CA, Bezemer R, Miranda DR, et al. Intra-operative assessment of human pulmonary alveoli in vivo using Sidestream Dark Field imaging: a feasibility study. Med Sci Monit. 2009;15(10):MT137–MT141.
25. Dubin A, Pozo MO, Ferrara G, et al. Systemic and microcirculatory responses to progressive hemorrhage. Intensive Care Med. 2009;35(3):556–564.
26. Puhl G, Schaser KD, Vollmar B, Menger MD, Settmacher U. Noninvasive in vivo analysis of the human hepatic microcirculation using orthogonal polorization spectral imaging. Transplantation. 2003;75(6):756–761.
27. Nilsson J, Eriksson S, Blind PJ, Rissler P, Sturesson C. Microcirculation changes during liver resection – a clinical study. Microvasc Res. 2014;94:47–51.
28. Boerma EC, van der Voort PH, Spronk PE, Ince C. Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med. 2007;35(4):1055–1060.
29. Dondorp AM, Ince C, Charunwatthana P, et al. Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. J Infect Dis. 2008;197(1):79–84.
30. Puhl G, Schaser KD, Pust D, et al. Initial hepatic microcirculation correlates with early graft function in human orthotopic liver transplantation. Liver Transpl. 2005;11(5):555–563.
31. De Backer D, Ospina-Tascon G, Salgado D, Favory R, Creteur J, Vincent JL. Monitoring the microcirculation in the critically ill patient: current methods and future approaches. Intensive Care Med. 2010;36(11):1813–1825.
32. Lindert J, Werner J, Redlin M, Kuppe H, Habazettl H, Pries AR. OPS imaging of human microcirculation: a short technical report. J Vasc Res. 2002;39(4):368–372.
33. Sturesson C, Milstein DM, Post IC, Maas AM, van Gulik TM. Laser speckle contrast imaging for assessment of liver microcirculation. Microvasc Res. 2013;87:34–40.
34. Cerny V, Turek Z, Parizkova R. Orthogonal polarization spectral imaging. Physiol Res. 2007;56(2):141–147.
35. Riva C, Ross B, Benedek GB. Laser Doppler measurements of blood flow in capillary tubes and retinal arteries. Invest Ophthalmol. 1972;11(11):936–944.
36. Humeau A, Steenbergen W, Nilsson H, Stromberg T. Laser Doppler perfusion monitoring and imaging: novel approaches. Med Biol Eng Comput. 2007;45(5):421–435.
37. Essex TJ, Byrne PO. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng. 1991;13(3):189–194.
38. Nilsson GE, Tenland T, Oberg PA. Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng. 1980;27(10):597–604.
39. Wardell K, Jakobsson A, Nilsson GE. Laser Doppler perfusion imaging by dynamic light scattering. IEEE Trans Biomed Eng. 1993;40(4):309–316.
40. O’Doherty J, McNamara P, Clancy NT, Enfield JG, Leahy MJ. Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration. J Biomed Opt. 2009;14(3): 034025.
41. Serov A, Steinacher B, Lasser T. Full-field laser Doppler perfusion imaging and monitoring with an intelligent CMOS camera. Opt Express. 2005;13(10):3681–3689.
42. Leutenegger M, Martin-Williams E, Harbi P, et al. Real-time full field laser Doppler imaging. Biomed Opt Express. 2011;2(6):1470–1477.
43. Draijer M, Hondebrink E, van Leeuwen T, Steenbergen W. Twente Optical Perfusion Camera: system overview and performance for video rate laser Doppler perfusion imaging. Opt Express. 2009;17(5): 3211–3225.
44. Briers JD. Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. Physiol Meas. 2001;22(4):R35–R66.
45. Stucker M, Horstmann I, Nuchel C, Rochling A, Hoffmann K, Altmeyer P. Blood flow compared in benign melanocytic naevi, malignant melanomas and basal cell carcinomas. Clin Exp Dermatol. 1999;24(2):107–111.
46. Khan F, Newton DJ. Laser Doppler imaging in the investigation of lower limb wounds. Int J Low Extrem Wounds. 2003;2(2):74–86.
47. Gschwandtner ME, Ambrozy E, Schneider B, Fasching S, Willfort A, Ehringer H. Laser Doppler imaging and capillary microscopy in ischemic ulcers. Atherosclerosis. 1999;142(1):225–232.
48. Niazi ZB, Essex TJ, Papini R, Scott D, McLean NR, Black MJ. New laser Doppler scanner, a valuable adjunct in burn depth assessment. Burns. 1993;19(6):485–489.
49. Pape SA, Baker RD, Wilson D, et al. Burn wound healing time assessed by laser Doppler imaging (LDI). Part 1: Derivation of a dedicated colour code for image interpretation. Burns. 2012;38(2):187–194.
50. Freccero C, Svensson H, Bornmyr S, Wollmer P, Sundkvist G. Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients. Diabetes Care. 2004;27(12):2936–2941.
51. Hajivassiliou CA, Greer K, Fisher A, Finlay IG. Non-invasive measurement of colonic blood flow distribution using laser Doppler imaging. Br J Surg. 1998;85(1):52–55.
52. Liu Y, Belayev L, Zhao W, Busto R, Belayev A, Ginsberg MD. Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies. Eur J Pharmacol. 2001;428(2):193–201.
53. Klonizakis M, Manning G, Donnelly R. Assessment of lower limb microcirculation: exploring the reproducibility and clinical application of laser Doppler techniques. Skin Pharmacol Physiol. 2011;24(3):136–143.
54. Fullerton A, Stucker M, Wilhelm KP, et al. Guidelines for visualization of cutaneous blood flow by laser Doppler perfusion imaging. A report from the Standardization Group of the European Society of Contact Dermatitis based upon the HIRELADO European community project. Contact Dermatitis. 2002;46(3):129–140.
55. Zhong J, Seifalian AM, Salerud GE, Nilsson GE. A mathematical analysis on the biological zero problem in laser Doppler flowmetry. IEEE Trans Biomed Eng. 1998;45(3):354–364.
56. Humeau-Heurtier A, Abraham P, Mahe G. Linguistic analysis of laser speckle contrast images recorded at rest and during biological zero: comparison with laser Doppler flowmetry data. IEEE Trans Med Imaging. Epub September 16, 2013.
57. Rigden JD, Gordon EI. The granularity of scattered optical maser light. Proc IRE. 1962;50:2367–2368.
58. Stern MD. In vivo evaluation of microcirculation by coherent light scattering. Nature. 1975;254(5495):56–58.
59. Tew GA, Klonizakis M, Crank H, Briers JD, Hodges GJ. Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function. Microvasc Res. 2011;82(3):326–332.
60. Binzoni T, Humeau-Heurtier A, Abraham P, Mahe G. Blood perfusion values of laser speckle contrast imaging and laser Doppler flowmetry: is a direct comparison possible? IEEE Trans Biomed Eng. 2013;60(5):1259–1265.
61. Briers JD, Fercher AF. Retinal blood-flow visualization by means of laser speckle photography. Invest Ophthalmol Vis Sci. 1982;22(2): 255–259.
62. Briers JD, Webster S. Laser speckle contrast analysis (LASCA): a nonscanning, full-field technique for monitoring capillary blood flow. J Biomed Opt. 1996;1(2):174–179.
63. Briers JD, Richards G, He XW. Capillary Blood Flow Monitoring Using Laser Speckle Contrast Analysis (LASCA). J Biomed Opt. 1999;4(1):164–175.
64. Lindahl F, Tesselaar E, Sjoberg F. Assessing paediatric scald injuries using Laser Speckle Contrast Imaging. Burns. 2013;39(4):662–666.
65. Hecht N, Woitzik J, Dreier JP, Vajkoczy P. Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis. Neurosurg Focus. 2009;27(4):E11.
66. Eriksson S, Nilsson J, Lindell G, Sturesson C. Laser speckle contrast imaging for intraoperative assessment of liver microcirculation: a clinical pilot study. Med Devices (Auckl). 2014;7(4):257–261.
67. Stewart CJ, Frank R, Forrester KR, Tulip J, Lindsay R, Bray RC. A comparison of two laser-based methods for determination of burn scar perfusion: laser Doppler versus laser speckle imaging. Burns. 2005;31(6):744–752.
68. Mahe G, Abraham P, Le Faucheur A, Bruneau A, Humeau-Heurtier A, Durand S. Cutaneous microvascular functional assessment during exercise: a novel approach using laser speckle contrast imaging. Pflugers Arch. 2013;465(4):451–458.
69. Mahe G, Rousseau P, Durand S, Bricq S, Leftheriotis G, Abraham P. Laser speckle contrast imaging accurately measures blood flow over moving skin surfaces. Microvasc Res. 2011;81(2):183–188.
70. MoorInstuments [homepage on the Internet]. Available from: http://gb.moor.co.uk/. Accessed October 26, 2014.