How to assess microvascular structure in humans

High Blood Pressure and Cardiovascular Prevention

Volumn 18, Issue 4, 2011, Pages 169-177

  Rizzoni, Damiano ^a   Aalkjaer, Christian ^b   De Ciuceis, Carolina ^a   Porteri, Enzo ^a   Rossini, Claudia ^a   Agabiti Rosei, Claudia ^a   Sarkar, Annamaria ^a   Agabiti Rosei, Enrico ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

microcirculation; resistance vasculature; retinal arterioles; small arteries

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ISOPRENALINE; NITROPRUSSIDE SODIUM;

ARTERIAL WALL THICKNESS; ARTERIOLE; BIOPSY; CAPILLAROSCOPY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; DIABETIC PATIENT; GOLD STANDARD; HUMAN; HYPERTENSION; LASER DOPPLER FLOWMETRY; MICROCIRCULATION; MICROVASCULAR ISCHEMIA; MYOGRAPHY; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; RESISTANCE BLOOD VESSEL; RETINA BLOOD VESSEL; RETINA INJURY; REVIEW; VASCULAR RESISTANCE;

ARTERIOLES; FOREARM; HUMANS; HYPERTENSION; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; MYOGRAPHY; PLETHYSMOGRAPHY; RETINAL VESSELS; TUNICA MEDIA; VASCULAR RESISTANCE;

EID: 84856369891     PISSN: 11209879     EISSN: 11791985     Source Type: Journal    
DOI: 10.2165/11593640-000000000-00000     Document Type: Review

References (52)

1. Mulvany MJ, Aalkjaer C. Structure and function of small arteries. Physiol Rev 1990; 70: 921-71
2. Folkow B. The resistance vasculature: functional importance in the circulation. In: Bevan JA, Halpern W, Mulvany MJ, editors. The resistance vasculature. New York: Humana Press, 1991: 23-44
3. Christensen KL, Mulvany MJ. Location of resistance arteries. J Vasc Res 2001; 38: 1-12 (Pubitemid 32171094)
4. Folkow B. Physiological aspects of primary hypertension. Physiol Rev 1982; 62: 347-504
5. Schiffrin EL. Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am J Hypertens 2004: 1192-200 (Pubitemid 40029420)
6. De Ciuceis C, Rizzoni D, Agabiti Rosei C, et al. Remodelling of small resistance arteries in essential hypertension. High Blood Press 2006; 13 (1): 1-6 (Pubitemid 43799991)
7. Mulvany MJ. Structural abnormalities of the resistance vasculature in hypertension. J Vasc Res 2003; 40: 558-60 (Pubitemid 38186466)
8. Mulvany MJ. Small artery remodeling and significance in the development of hypertension. News Physiol Sci 2002; 17: 105-9
9. Pedrinelli R, Taddei S, Spessot M, et al. Maximal postischemic forearm vasodilation in human hypertension: a reassessment of the method. J Hypertens 1987; 5 Suppl. 5: S431-3 (Pubitemid 18074949)
10. Pedrinelli R, Spessot M, Salvetti A. Reactive iperemia during short-term blood flow and pressure changes in the hypertensive forearm. J Hypertens 1990; 8: 467-71 (Pubitemid 20347081)
11. Mulvany MJ, Halpern W. Contractile properties of small resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977; 41 (1): 19-26 (Pubitemid 8132079)
12. Mulvany MJ, Hansen PK, Aalkjaer C. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers. Circ Res 1978; 43 (6): 854-64
13. Aalkjaer C, Eiskjaer H, Mulvany MJ, et al. Abnormal structure and function of isolated subcutaneous resistance vessels from essential hypertensive patients despite antihypertensive treatment. J Hypertens 1989; 7: 305-10 (Pubitemid 19128745)
14. Aalkjaer C, Heagerty AM, Petersen KK, et al. Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitationcontraction coupling in isolated resistance vessels from essential hypertensives. Circ Res 1987; 61: 181-6 (Pubitemid 17137117)
15. Agabiti-Rosei E, Rizzoni D, Castellano M, et al. Media: lumen ratio in human small resistance arteries is related to forearm minimal vascular resistance. J Hypertens 1995; 13: 341-7
16. Schiffrin EL, Deng LY. Structure and function of resistance arteries of hypertensive patients treated with a beta-blocker or a calcium channel antagonist. J Hypertens 1996; 14: 1247-55 (Pubitemid 26343505)
17. Schiffrin EL, Hayoz D. How to assess vascular remodelling in small and medium-sized muscular arteries in humans. J Hypertens 1997; 15: 571-84 (Pubitemid 27246532)
18. Greene AS, Tonellato PJ, Lui J, et al. Microvascular rarefaction and tissue vascular resistance in hypertension. Am J Physiol 1989; 256: H126-31
19. Schiffrin EL. Reactivity of small blood vessels in hypertension: relation with structural changes: state of the art lecture.Hypertension 1992; 19 Suppl. II: II1-9
20. Struijker-Boudier HAJ. Microcirculation in hypertension. Eur Heart J 1999; 1 Suppl. L: L32-7
21. Harper RN, Moore MA, Marr MC, et al. Arteriolar rarefaction in the conjunctiva of human essential hypertensies. Microvasc Res 1978; 16: 369-72 (Pubitemid 9133984)
22. Gasser P, Bühler FR. Nailfold microcirculation in normotensive and essential hypertensive subjects, as assessed by video-microscopy. JHypertens 1992; 10: 83-6
23. Antonios TF, Singer DR, Markandu ND, et al. Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality. Hypertension 1999; 34 (4 Pt 1): 655-8 (Pubitemid 29496449)
24. Antonios TF, Singer DR, Markandu ND, et al. Structural skin capillary rarefaction in essential hypertension. Hypertension 1999; 33 (4): 998-1001 (Pubitemid 29186398)
25. Antonios TF, Rattray FM, Singer DR, et al. Rarefaction of skin capillaries in normotensive offspring of individuals with essential hypertension. Heart 2003; 89 (2): 175-8 (Pubitemid 36115101)
26. Shore AC. Capillaroscopy and the measurement of capillary pressure. Br J Clin Pharmacol 2000; 50: 501-13 (Pubitemid 32010011)
27. Lever AF. Slow pressor mechanisms in hypertension: a role for hypertrophy of resistance vessels? J Hypertens 1986; 4: 515-24
28. Rizzoni D, Porteri E, Platto C, et al. Morning rise of blood pressure and subcutaneous small resistance artery structure. JHypertens 2007 Aug; 25 (8): 1698-703 (Pubitemid 47056578)
29. Rizzoni D, Palombo C, Porteri E, et al. Relationships between coronary vasodilator capacity and small artery remodeling in hypertensive patients. J Hypertens 2003; 21: 625-32
30. Muiesan ML, Rizzoni D, Salvetti M, et al. Structural changes in small resistance arteries and left ventricular geometry in patients with primary and secondary hypertension. J Hypertens 2002; 20: 1439-44 (Pubitemid 34925690)
31. Rizzoni D, Porteri E, Guelfi D, et al. Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non insulin dependent diabetes mellitus. Circulation 2001; 103: 1238-44 (Pubitemid 32221346)
32. Rizzoni D, Porteri E, Boari GEM, et al. Prognostic significance of small artery structure in hypertension. Circulation 2003; 108: 2230-5 (Pubitemid 37363040)
33. De Ciuceis C, Porteri E, Rizzoni D, et al. Structural alterations of subcutaneous small arteries may predict major cardiovascular events in hypertensive patients. Am J Hypertens 2007; 20: 846-52 (Pubitemid 47176353)
34. Mathiassen ON, Buus NH, Sihm I, et al. Small artery structure is an independent predictor of cardiovascular events in essential hypertension. J Hypertens 2007; 25: 1021-6 (Pubitemid 46573121)
35. Paiardi S, Rodella LF, De Ciuceis C, et al. Immunohistochemical evaluation of microvascular rarefaction in hypertensive humans and in spontaneously hypertensive rats. Clin Hemorheol Microcirc 2009; 42: 259-68
36. Christensen KL, Mulvany MJ. Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey. J Hypertens 2001; 19: 1001-6 (Pubitemid 32493631)
37. The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2007 Guidelines for the management of arterial hypertension. JHypertens 2007; 25: 1105-87
38. Mancia G, Laurent S, Agabiti-Rosei E, et al., European Society of Hypertension. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens 2009; 27: 2121-58
39. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 2004; 351: 2310-7 (Pubitemid 39552747)
40. Rizzoni D, De Ciuceis C, Porteri E, et al. Altered structure of small cerebral arteries in patients with essential hypertension. J Hypertens 2009; 27: 838-45
41. Wong TY, Klein R, Sharrett AR, et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA 2002; 287: 1153-9 (Pubitemid 34252085)
42. Masaidi M, Cuspidi C, Giudici V, et al. Is retinal arteriolar-venular ratio associated with cardiac and extracardiac organ damage in essential hypertension? J Hypertens 2009; 27: 1277-83
43. Hughes AD, Martinez-Perez E, Jabbar AS, et al. Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension. J Hypertens 2006; 24: 889-94 (Pubitemid 43670460)
44. Hughes AD, Stanton AV, Jabbar AS, et al. Effect of antihypertensive treatment on retinal microvascular changes in hypertension. J Hypertens 2008; 26: 1703-7
45. Harazny JM, Ritt M, Baleanu D, et al. Increased wall : lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event. Hypertension 2007; 50 (4): 623-829
46. Ritt M, Harazny JM, Ott C, et al. Analysis of retinal arteriolar structure in never-treated patients with essential hypertension. J Hypertens 2008; 26 (7): 1427-34
47. Ritt M, Harazny JM, Ott C, et al. Wall-to-lumen ratio of retinal arterioles is related with urinary albumin excretion and altered vascular reactivity to infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine. J Hypertens 2009; 27: 2201-18
48. Baleanu D, Ritt M, Harazny J, et al. Wall-to-lumen ratio of retinal arterioles and arteriole-to-venule ratio of retinal vessels in patients with cerebrovascular damage. Invest Ophthalmol Vis Sci 2009; 50: 4351-9
49. Harazny JM, Raff U, Welzenbach J, et al. New software analyses increase the reliability of measurements of retinal arterioles morphology by scanning laser Doppler flowmetry in humans. J Hypertens 2011; 29: 777-82
50. Heagerty AM. Predicting hypertension complications from small artery structure. J Hypertens 2007; 25 (5): 939-40 (Pubitemid 46573110)
51. Schiffrin EL, Touyz RM. From bedside to bench to bedside: role of reninangiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol 2004; 287: H435-46 (Pubitemid 38960790)
52. Mulvany MJ. Small artery structure: time to take note? Am J Hypertens 2007; 20: 853-4 (Pubitemid 47176357)