Intra-operative assessment of human pulmonary alveoli in vivo using Sidestream Dark Field imaging: A feasibility study

Medical Science Monitor

Volumn 15, Issue 10, 2009, Pages

  Den Uil, Corstiaan A ^a   Bezemer, Rick ^a   Miranda, Dinis R ^a   Ince, Can ^a   Lagrand, Wim K ^b   Hartman, J Michael ^a   Bogers, Ad J ^a   Spronk, Peter E ^c   Simoons, Maarten L ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c GELRE HOSPITALS   (Netherlands)

Author keywords

Alveolar mechanics; Human; Pleura; Sidestream dark field imaging; Videomicroscopy

Indexed keywords

ADULT; ARTICLE; ARTIFACT; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; DIAGNOSTIC IMAGING; FEMALE; HEART SURGERY; HUMAN; INFANT; INTRAOPERATIVE PERIOD; LUNG ALVEOLUS; MALE; MICROCIRCULATION; SIDESTREAM DARK FIELD IMAGING;

ADULT; AGED, 80 AND OVER; CHILD, PRESCHOOL; DIAGNOSTIC IMAGING; FEASIBILITY STUDIES; FEMALE; HUMANS; INFANT; INTRAOPERATIVE CARE; MALE; MICROCIRCULATION; MIDDLE AGED; PULMONARY ALVEOLI;

EID: 70349976985     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Dreyfuss D, Saumon G: Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med, 1998; 157(1): 294-323 (Pubitemid 28071297)
2. Gattinoni L, Pelosi P, Crotti S, Valenza F: Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. Am J Respir Crit Care Med, 1995; 151(6): 1807-1814
3. Rubenfeld GD: Epidemiology of acute lung injury. Crit Care Med, 2003; 31(4 Suppl.): S276-84
4. Pinhu L, Whitehead T, Evans T, Griffiths M: Ventilator-associated lung injury. Lancet, 2003; 361(9354): 332-340
5. Fujita Y, Fujino Y, Uchiyama A et al: High peak inspiratory flow can aggravate ventilator-induced lung injury in rabbits. Med Sci Monit, 2007; 13(4): BR95-100 (Pubitemid 46557746)
6. Schultz M: Lung-protective mechanical ventilation with lower tidal volumes in patients not suffering from acute lung injury: A review of clinical studies. Med Sci Monit, 2008; 14(2): RA22-26
7. Brown RH, Irvin CG, Allen GB et al: An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology. Proc Am Thorac Soc, 2008; 5(5): 591-600
8. Thiberville L, Salaun M, Lachkar S et al: Human in vivo fluorescence microimaging of the alveolar ducts and sacs during bronchoscopy. Eur Respir J, 2009; 33(5): 974-985
9. Allen GB, Pavone LA, DiRocco JD et al: Pulmonary impedance and alveolar instability during injurious ventilation in rats. J Appl Physiol, 2005; 99(2): 723-730
10. Goedhart PT, Khalilzada M, Bezemer R et al: Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Optics Express, 2007; 15(23): 15101-15114 (Pubitemid 350127674)
11. Bezemer R, Khalilzada M, Ince C: Recent advancements in microcirculatory image acquisition and analysis. In: Vincent JL (ed.), Yearbook of Intensive Care and Emergency Medicine. Berlin, Springer, 2008; 677-690
12. den Uil CA, Lagrand WK, Spronk PE et al: Impaired sublingual microvascular perfusion during surgery with cardiopulmonary bypass: A pilot study. J Thorac Cardiovasc Surg, 2008; 135: 129-134
13. Lai-Fook SJ: Pleural mechanics and fluid exchange. Physiol Rev, 2004; 84: 385-410
14. den Uil CA, Klijn E, Lagrand WK et al: The microcirculation in health and critical disease. Progr Cardiovasc Dis, 2008; 51: 161-170
15. Carney DE, Bredenberg CE, Schiller HJ et al: The Mechanism of Lung Volume Change during Mechanical Ventilation. Am J Respir Crit Care Med, 1999; 160(5): 1697-1702
16. Schiller HJ, McCann UG, Carney DE et al: Altered alveolar mechanics in the acutely injured lung. Crit Care Med, 2001; 29(5): 1049-1055
17. McCann UG, Schiller HJ, Carney DE et al: Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level. J Surg Res, 2001; 99(2): 335-342
18. Van Golde LM, Batenburg JJ, Robertson B: The pulmonary surfactant system: biochemical aspects and functional significance. Physiol Rev, 1988; 68(2): 374-455
19. Halter JM, Steinberg JM, Schiller HJ et al: Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med, 2003; 167(12): 1620-1626
20. Steinberg J, Schiller HJ, Halter JM et al: Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation. Crit Care Med, 2002; 30(12): 2675-2683 (Pubitemid 36870569)
21. Carney DE, DiRocco J, Nieman GF: Dynamic alveolar mechanics and ventilator- induced lung injury. Crit Care Med, 2005; 33(3 Suppl.): S122-28 (Pubitemid 40365598)
22. Rouby JJ, Puybasset L, Nieszkowska A, Lu Q: Acute respiratory distress syndrome: lessons from computed tomography of the whole lung. Crit Care Med, 2003; 31(4 Suppl.): S285-95 (Pubitemid 36458181)
23. den Uil CA, Lagrand WK, Spronk PE et al: Low-dose nitroglycerin improves microcirculation in hospitalized patients with acute heart failure. Eur J Heart Fail, 2009; 11(4): 386-390