Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues

Lipids

Volumn 49, Issue 10, 2014, Pages 963-973

  Watanabe, Shiro ^a   Fujita, Kyosuke ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Bile acid pool; Desaturation; Farnesoid X receptor; Lipogenesis; Monounsaturated fatty acid; Stearoyl CoA desaturase 1

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE 1; CHOLESTEROL 7ALPHA MONOOXYGENASE; DIACYLGLYCEROL ACYLTRANSFERASE 2; FATTY ACID SYNTHASE; HEPTADECANOIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYODEOXYCHOLIC ACID; MONOUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; ACYL COENZYME A DESATURASE; ANTILIPEMIC AGENT; BILE ACID; CELL RECEPTOR; CHOLAGOGUE; DEOXYCHOLIC ACID; FARNESOID X-ACTIVATED RECEPTOR; FATTY ACID; MESSENGER RNA; SCD1 PROTEIN, MOUSE; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; FATTY ACID ANALYSIS; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; FLUID INTAKE; FOOD INTAKE; GAS LIQUID CHROMATOGRAPHY; GENE EXPRESSION; HYPOLIPIDEMIC EFFECT; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPOGENESIS; LIQUID CHROMATOGRAPHY; LIVER; LIVER WEIGHT; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; THIN LAYER CHROMATOGRAPHY; WEIGHT GAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; DRUG EFFECTS; ENTEROHEPATIC CIRCULATION; GENETICS; LIPID METABOLISM; METABOLISM; PHYSIOLOGY;

MUS; SUIDAE;

ACETYL-COA CARBOXYLASE; ANIMALS; BILE ACIDS AND SALTS; CHOLAGOGUES AND CHOLERETICS; DEOXYCHOLIC ACID; DIETARY SUPPLEMENTS; ENTEROHEPATIC CIRCULATION; FATTY ACID SYNTHASE, TYPE I; FATTY ACIDS; GENE EXPRESSION; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84919393757     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-014-3947-y     Document Type: Article

References (39)

1. Keitel V, Kubitz R, Häussinger D (2008) Endocrine and paracrine role of bile acids. World J Gastroenterol 14:5620-5629
2. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89:147-191
3. Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J (2004) Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113:1408-1418
4. Bilz S, Samuel V, Morino K, Savage D, Choi CS, Shulman GI (2006) Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. Am J Physiol Endocrinol Metab 290:E716-E722
5. Einarsson C, Hillebrant CG, Axelson M (2001) Effects of treatment with deoxycholic acid and chenodeoxycholic acid on the hepatic synthesis of cholesterol and bile acids in healthy subjects. Hepatology 33:1189-1193
6. Song KH, Li T, Owsley E, Strom S, Chiang JY (2009) Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49:297-305
7. Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102:731-744
8. Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA (2006) Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. Proc Natl Acad Sci USA 103:1006-1011
9. Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA (2010) Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. J Biol Chem 285:3035-3043
10. Fiorucci S, Cipriani F, Baldelli A, Mencarelli A (2010) Bile acid-activated receptors in the treatment of dyslipidemia and related disorders. Prog Lipid Res 49:171-185
11. Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284(5418):1365-1368
12. Watanabe S, Tsuneyama K (2010) A triglyceride-lowering effect of cattle bile is associated with elevation of cholesterol levels and liver injury in mice. J Trad Med 27:179-185
13. Watanabe S, Tsuneyama K (2012) Cattle bile but not bear bile and pig bile induce lipid profile changes and fatty liver injury in mice. J Toxicol Sci 37:105-121
14. Watanabe S, Fujita K (2013) Pig bile reduces hepatic triglyceride content in mice. J Trad Med 30:190-197
15. Qiao X, Ye M, Pan DL, Miao WJ, Xiang C, Han J, Guo DA (2011) Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. J Chromatogr A 1218:107-117
16. Cohen-Solal C, Parquet M, Férézou J, Sérougne C, Lutton C (1995) Effects of hyodeoxycholic acid and alpha-hyocholic acid, two 6alpha-hydroxylated bile acids, on cholesterol and bile acid metabolism in the hamster. Biochim Biophys Acta 1257:189-197
17. Wang DQ, Tazuma S, Cohen DE, Carey MC (2003) Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol 285:G494-G502
18. Hara A, Radin N (1978) Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 90:420-426
19. Alnouti Y, Csanaky IL, Klaassen CD (2008) Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B 873:209-217
20. Russell DW, Setcehll KD (1992) Bile acid biosynthesis. Biochemistry 31:4737-4749
21. Li-Hawkins J, Ga˚fvels M, Olin M, Lund EG, Andersson U, Schuster G, Björkhem I, Russell DW, Eggertsen G (2002) Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest 110:1191-1200
22. Miyazaki M, Bruggink SM, Ntambi JM (2006) Identification of mouse palmitoyl-coenzyme A Delta 9-desaturase. J Lipid Res 47:700-704
23. Miyazaki M, Kim YC, Ntambi JM (2001) A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res 42:1018-1024
24. Jonas A (1998) Regulation of lecithin cholesterol acyltransferase activity. Prog Lipid Res 37:209-234
25. Jonas A (2000) Lecithin cholesterol acyltransferase. Biochim Biophys Acta 1529:245-256
26. Bilz S, Samuel V, Morino K, Savage D, Choi CS, Shulman GI (2005) Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. Am J Physiol Endocrinol Metab 290:E716-E722
27. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ (2002) Vitamin D receptor as an intestinal bile acid sensor. Science 296:1313-1316
28. Howard WR, Pospisil JA, Njolito E, Noonan DJ (2000) Catabolites of cholesterol synthesis pathways and forskolin as activators of farnesoid X-activated unclear receptor. Toxicol Appl Pharmacol 163:195-202
29. Sayin SI, Wahlström A, Felin J, Jäntti S, Marschall HU, Bamberg K, Angelin B, Hyötyläinen T, Orešič M, Bäckhed F (2013) Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17:225-235
30. Hu X, Bonde Y, Eggertsen G, Rudling M (2014) Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism. J Intern Med 275:27-38
31. Cohen BI, Singhal AK, Mongelli J, Rothschild MA, McSherry CK, Mosbach EH (1983) Hydroxylation of secondary bile acids in the perfused prairie dog liver. Lipids 18:909-912
32. Bodin K, Lindbom U, Diczfalusy U (2005) Novel pathways of bile acid metabolism involving CYP3A4. Biochim Biophys Acta 1687:84-93
33. Alrefai WA, Gill RK (2007) Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 24:1803-1823
34. Wang H, Chen J, Hollister K, Sowers LC, Forman BM (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3:543-553
35. Okuyama H, Kobayashi T, Watanabe S (1996) Dietary fatty acids -the N-6/N-3 balance and chronic elderly diseases. Excess linoleic acid and relative N-3 deficiency syndrome seen in Japan. Prog Lipid Res 35:409-457
36. Jakobsson A, Westerberg R, Jacobsson A (2006) Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res 45:237-249
37. Smith WL (2005) Cyclooxygenases, peroxide tone and the allure of fish oil. Curr Opin Cell Biol 17:174-182
38. Serhan CN, Chiang N, Van Dyke TE (2008) Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8:349-361
39. Ferré P, Foufelle F (2010) Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab Suppl 2:83-92