Pig bile reduces hepatic triglyceride content in mice

Journal of Traditional Medicines

Volumn 30, Issue 4, 2013, Pages 190-197

  Watanabe, Shiro ^a   Fujita, Kyosuke ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Bile acid; lipogenesis; monounsaturated fatty acid; Scd activity index; stearoyl CoA desaturase 1; sterol regulatory element binding protein 1c

Indexed keywords

EID: 84919334425     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.30.190     Document Type: Article

References (21)

1. Keitel, V., Kubitz, R. and Häussinger, D.: Endocrine and paracrine role of bile acids. World J. Gastroenterol., 14, 5620-5629, 2008.
2. Lefebvre, P., Cariou, B., Lien, F., Kuipers, F. and Staels, B.: Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev., 89, 147-191, 2009.
3. Watanabe, M., Houten, S.M., Wang, L., Moschetta, A., Mangelsdorf, D.J., Heyman, R.A., Moore, D.D. and Auwerx, J.: Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J. Clin. Invest., 113, 1408-1418, 2004.
4. Watanabe, S. and Tsuneyama, K.: A triglyceride-lowering effect of cattle bile is associated with elevation of cholesterol levels and liver injury in mice. J. Trad. Med., 27, 179-185, 2010.
5. Watanabe, S. and Tsuneyama, K.: Cattle bile but not bear bile and pig bile induce lipid profile changes and fatty liver injury in mice. J. Toxicol. Sci., 37, 105-121, 2012.
6. Qiao, X., Ye, M., Pan, D.L., Miao, W.J., Xiang, C., Han, J. and Guo, D.A.: Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A., 1218, 107-117, 2011.
7. Cohen-Solal, C., Parquet, M., Férézou, J., Srougne, C. and Lutton, C.: Effects of hyodeoxycholic acid and alpha-hyocholic acid, two 6 alpha-hydroxylated bile acids, on cholesterol and bile acid metabolism in the hamster. Biochim Biophys Acta, 1257, 189-197, 1995.
8. Sehayek, E., Ono, J.G., Duncan, E.M., Batta, A.K., Salen, G., Shefer, S., Neguyen, L.B., Yang, K., Lipkin, M. and Breslow, J.L.: Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice. J. Lipid Res., 42, 1250-1256, 2001.
9. Wang, D.Q., Tazuma, S., Cohen, D.E., Carey, M.C.: Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am. J. Physiol. Gastrointest. Liver Physiol., 285, G494-502, 2003.
10. Watanabe, S., Kamei, T., Tanaka, K., Kawasuji, K., Yoshioka, T. and Ohno, M.: Roles of bile acid conjugates and phospholipids in in vitro activation of pancreatic lipase by bear bile and cattle bile. J. Ethnopharmacol., 125, 203-206, 2009.
11. Parks, D.J., Blanchard, S.G., Bledsoe, R.K., Chandra, G., Consler, T.G., Kliewer, S.A., Stimmel, J.B., Willson, T.M., Zavacki, A.M., Moore, D.D. and Lehmann, J.M.: Bile acids: natural ligands for an orphan nuclear receptor. Science, 284 (5418), 1365-1368, 1999.
12. Hara, A. and Radin, N.: Lipid extraction of tissues with a low-toxicity solvent. Anal. Biochem., 90, 420-426, 1978.
13. Bjermo, H. and Riserus, U.: Role of hepatic desaturases in obesity-related metabolic disorders. Curr. Opin. Clin. Nutr. Metab. Care, 13, 703-708, 2010.
14. Miyazaki, M., Bruggink, S.M. and Ntambi, J.M.: Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J. Lipid Res., 47, 700-704, 2006.
15. Warensjö, E., Risérus, U., Gustafsson, I.B., Mohsen, R., Cederholm, T. and Vessby, B.: Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. Nutr. Metab. Cardiovasc. Dis., 18, 683-690, 2008.
16. Miyazaki, M., Kim, Y.C. and Ntambi, J.M.: A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res., 42, 1018-1024, 2001.
17. Bateson, M.C., Maclean, D., Evans, J.R. and Bouchier, I.A.D.: Chenodeoxycholic acid therapy for hypertriglyceridemia in men. Br. J. Clin. Pharmacol., 5, 249-254, 1978.
18. Stange, E.F., Scheibner, J. and Ditschuneit, H.: Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rats in vivo. J. Clin. Invest. 84, 173-180, 1989.
19. Uchida, K., Nomura, Y. and Takeuchi, N.: Effect of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipids, and bile acid levels in serum, liver, and feces of rats. J. Biochem., 87, 187-194, 1980.
20. Watanabe, M., Houten, S.M., Mataki, C., Christoffolete, M.A., Kim, B.W., Sato, H., Messaddeq, N., Harney, J.W., Ezaki, O., Kodama, T., Schoonjans, K., Bianco, A.C. and Auwerx, J.: Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 439 (7075), 484-489, 2006.
21. Ferré, P. and Foufelle, F.: Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes. Metab. Suppl. 2, 83-92, 2006.