Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation

Molecular Cancer Research

Volumn 12, Issue 12, 2014, Pages 1818-1828

  Lee, Minnkyong ^a   Dworkin, Amy M ^a   Lichtenberg, Jens ^a   Patel, Shashank J ^a   Trivedi, Niraj S ^a   Gildea, Derek ^a   Bodine, David M ^a   Crawford, Nigel P S ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCHROMATIN PROTEIN 1 ALPHA; HISTONE H3; METASTASIS ASSOCIATED TRANSCRIPTION; NUCLEAR PROTEIN; PROTEIN; RIBOSOMAL RNA PROCESSING 1 HOMOLOG B; RIBOSOME RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TUMOR MARKER; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CHROMATIN; HETEROCHROMATIN-SPECIFIC NONHISTONE CHROMOSOMAL PROTEIN HP-1; HISTONE; NONHISTONE PROTEIN; REPRESSOR PROTEIN; RRP1B PROTEIN, HUMAN; TRIM28 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER GROWTH; CELL GROWTH; CELL INVASION; CELL MOTILITY; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HIGH THROUGHPUT SEQUENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; PROTEIN FUNCTION; RNA PROCESSING; TUMOR INVASION; UPREGULATION; ANIMAL; BREAST TUMOR; CHEMISTRY; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HELA CELL LINE; LUNG TUMOR; METABOLISM; METHYLATION; MOUSE; PATHOLOGY; SECONDARY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOMAL PROTEINS, NON-HISTONE; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HISTONES; HUMANS; LUNG NEOPLASMS; METHYLATION; MICE; NEOPLASMS, EXPERIMENTAL; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84919393094     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0167     Document Type: Article

References (37)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63:11-30.
2. Scully OJ, Bay BH, Yip G, Yu Y. Breast cancer metastasis. Cancer Genomics Proteomics 2012;9:311-20.
3. Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006;5:37-50.
4. Hunter KW, Crawford NP. The future of mouse QTL mapping to diagnose disease in mice in the age of whole-genome association studies. Annu Rev Genet 2008;42:131-41.
5. Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, et al. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. PLoS genetics 2007;3:e214.
6. Crawford NP, Yang H, Mattaini KR, Hunter KW. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. J Biol Chem 2009;284:28660-73.
7. Hsieh SM, Look MP, Sieuwerts AM, Foekens JA, Hunter KW. Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. Breast Cancer Res 2009;11:R75.
8. Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, et al. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J 1999;18:6385-95.
9. Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ III. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 2002;16:919-32.
10. Schultz DC, Friedman JR, Rauscher FJ III. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev 2001;15:428-43.
11. Ryan RF, Schultz DC, Ayyanathan K, Singh PB, Friedman JR, Fredericks WJ, et al. KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol 1999;19:4366-78.
12. Frietze S, O'Geen H, Blahnik KR, Jin VX, Farnham PJ. ZNF274 recruits the histone methyltransferase SETDB1 to the 30 ends of ZNF genes. PLoS ONE 2010;5:e15082.
13. Iyengar S, FarnhamPJ. KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem 2011;286:26267-76.
14. Hublitz P, Albert M, Peters AH. Mechanisms of transcriptional repression by histone lysine methylation. Int J Dev Biol 2009;53:335-54.
15. O'Geen H, Squazzo SL, Iyengar S, Blahnik K, Rinn JL, Chang HY, et al. Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet 2007;3:e89.
16. Sripathy SP, Stevens J, Schultz DC. The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger proteinmediated transcriptional repression. Mol Cell Biol 2006;26:8623-38.
17. Alsarraj J, Walker RC, Webster JD, Geiger TR, Crawford NP, Simpson RM, et al. Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transi-tion-and stem cell-like conversion. Cancer Res 2011;71:3121-31.
18. Crawford NP, Alsarraj J, Lukes L, Walker RC, Officewala JS, Yang HH, et al. Bromodomain 4 activation predicts breast cancer survival. Proc Natl Acad Sci U S A 2008;105:6380-5.
19. Warnes GR, Bolker B, Bonebakker L, Gentleman R, Huber W, Liaw A, et al. gplots: Various R programming tools for plotting data. R package version 2.11.3 2013
20. Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, RichterM, et al. p53 is regulated by the lysine demethylase LSD1. Nature 2007;449:105-8.
21. Jurka J, Kapitonov VV, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J. Repbase Update, a database of eukaryotic repetitive elements. Cytogenet Genome Res 2005;110:462-7.
22. Fujita PA, Rhead B, Zweig AS, Hinrichs AS, Karolchik D, ClineMS, et al. The UCSC genome browser database: update 2011. Nucleic Acids Res 2011;39:D876-82.
23. Langmead B, Trapnell C, Pop M, Salzberg SL. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol 2009;10:R25.
24. Illingworth RS, Gruenewald-Schneider U,Webb S, Kerr AR, James KD, Turner DJ, et al. Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet 2010;6:e1001134.
25. Lee M, Dworkin AM, Gildea D, Trivedi NS, Moorhead GB, Crawford NP. RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. Oncogene 2014;33:1818-27.
26. Iyengar S, Ivanov AV, Jin VX, Rauscher FJ III, Farnham PJ. Functional analysis of KAP1 genomic recruitment.Mol Cell Biol 2011;31:1833-47.
27. Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nat Genet 2003;33:49-54.
28. van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, et al. Gene expression pro filing predicts clinical outcome of breast cancer. Nature 2002;415:530-6.
29. van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009.
30. Paik S. Is gene array testing to be considered routine now? Breast 2011;20:S87-91.
31. Li Q, Seo JH, Stranger B, McKenna A, Pe'er I, Laframboise T, et al. Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell 2013;152:633-41.
32. Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003;422:735-8.
33. Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifi ers that occupies E2F- and Mycresponsive genes in G0 cells. Science 2002;296:1132-6.
34. Chamousset D, De Wever V, Moorhead GB, Chen Y, Boisvert FM, Lamond AI, et al. RRP1Btargets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. Mol Biol Cell 2010;21:4212-26.
35. Krishnakumar R, Gamble MJ, Frizzell KM, Berrocal JG, Kininis M, Kraus WL. Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes. Science 2008;319:819-21.
36. Gonzalez V, Guo K, Hurley L, Sun D. Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. J Biol Chem 2009;284:23622-35.
37. Li Z, Boone D, Hann SR. Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation. Proc Natl Acad Sci U S A 2008;105:18794-9.