Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34583-34594

  Sand, Kine Marita Knudsen ^a,b   Bern, Malin ^a,b   Nilsen, Jeannette ^a,b   Dalhus, Bjørn ^b,c   Gunnarsen, Kristin Støen ^b   Cameron, Jason ^c   Grevys, Algirdas ^a,b   Bunting, Karen ^a   Sandlie, Inger ^a,b   Andersen, Jan Terje ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c Novozymes Biopharma DK A S   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BODY FLUIDS; MACROPHAGES; PROTEINS;

AMINO ACID RESIDUES; C-TERMINAL DOMAINS; HUMAN SERUM ALBUMINS; INTRACELLULAR DEGRADATION; N-TERMINAL DOMAINS; NEONATAL FC RECEPTORS; STRUCTURAL INSPECTIONS; STRUCTURAL MECHANISMS;

FATTY ACIDS;

AMINO ACID; FC RECEPTOR; HUMAN SERUM ALBUMIN; PROTEIN VARIANT; RECOMBINANT PROTEIN; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; PROTEIN BINDING; SERUM ALBUMIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; BIOENGINEERING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MISSENSE MUTATION; MUTAGENESIS; NEWBORN; NONHUMAN; PH; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RECEPTOR BINDING; STRUCTURE ANALYSIS; AMINO ACID SUBSTITUTION; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, FC; SERUM ALBUMIN;

EID: 84919372179     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.587675     Document Type: Article

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