Human serum albumin isoforms: Genetic and molecular aspects and functional consequences

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 12, 2013, Pages 5405-5417

  Kragh Hansen, Ulrich ^a   Minchiotti, Lorenzo ^b   Galliano, Monica ^b   Peters Jr , Theodore ^c  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF PAVIA   (Italy)

^c BASSETT HEALTHCARE   (United States)

Author keywords

Alloalbumin; Biodistribution; Drug targeting; Ligand binding; Mutation; Proalbumin

Indexed keywords

ALBUMIN; ARGININE; COPPER; DINUCLEOTIDE; HUMAN SERUM ALBUMIN; ISOPROTEIN; LEUCINE; LEVOTHYROXINE; LIOTHYRONINE; NICKEL;

ALBUMIN BLOOD LEVEL; ALBUMIN GENE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; DISEASE ASSOCIATION; EXON; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA HALF LIFE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STABILITY; REVIEW;

ALLOALBUMIN; BIODISTRIBUTION; DRUG TARGETING; LIGAND BINDING; MUTATION; PROALBUMIN;

HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ISOFORMS; SERUM ALBUMIN;

MUS;

EID: 84885376431     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.03.026     Document Type: Review

References (131)

1. T. Peters Jr. All About Albumin: Biochemistry, Genetics and Medical Applications 1996 Academic Press San Diego, CA
2. U. Kragh-Hansen Molecular aspects of ligand binding to serum albumin Pharmacol. Rev. 33 1981 17 53
3. D.C. Carter, and J.X. Ho Structure of serum albumin Adv. Prot. Chem. 45 1994 153 203 (Pubitemid 24139888)
4. U. Kragh-Hansen, V.T.G. Chuang, and M. Otagiri Practical aspects of the ligand-binding and enzymatic properties of human serum albumin Biol. Pharm. Bull. 25 2002 695 704 (Pubitemid 40036701)
5. G. Fanali, A. di Masi, V. Trezza, M. Marino, M. Fasano, and P. Ascenzi Human serum albumin: from bench to bedside Mol. Aspects Med. 33 2012 209 290
6. Y. Iwao, Y. Ishima, J. Yamada, T. Noguchi, U. Kragh-Hansen, K. Mera, D. Honda, A. Suenaga, T. Maruyama, and M. Otagiri Quantitative evaluation of the role of cysteine and methionine residues in the antioxidant activity of human serum albumin using recombinant mutants IUBMB Life 64 2012 450 454
7. X.M. He, and D.C. Carter Atomic structure and chemistry of human serum albumin Nature 358 1992 209 215
8. S. Curry, H. Mandelkow, P. Brick, and N. Franks Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites Nature Struct. Biol. 5 1998 827 835 (Pubitemid 28402087)
9. S. Sugio, A. Kashima, S. Mochizuki, M. Noda, and K. Kobayashi Crystal structure of human serum albumin at 2.5 Å resolution Prot. Eng. 12 1999 439 446 (Pubitemid 29322441)
10. K.L. Hein, U. Kragh-Hansen, J.P. Morth, M.D. Jeppesen, D. Otzen, J.V. Møller, and P. Nissen Crystallographic analysis reveals a unique lidocaine binding site on human serum albumin J. Struct. Biol. 171 2010 353 360
11. J.R. Olivieri, and A.F. Craievich The subdomain structure of human serum albumin in solution under different pH conditions studied by small angle X-ray scattering Eur. Biophys. J. 24 1995 77 84
12. M.L. Ferrer, R. Duchowicz, B. Carrasco, J.G. de la Torre, and A.U. Acuna The conformation of serum albumin in solution: a combined phosphorescence depolarization-hydrodynamic modeling study Biophys. J. 80 2001 2422 2430 (Pubitemid 32402004)
13. M. Speeckaert, G. Huang, J.R. Delanghe, and Y.E.C. Taes Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism Clin. Chim. Acta 372 2006 33 42 (Pubitemid 44286753)
14. S. Naidu, M.L. Peterson, and B.T. Spear Alpha-fetoprotein related gene (ARG): a new member of the albumin gene family that is no longer functional in primates Gene 449 2010 95 102
15. Y.-H. Song, A.K. Naumova, S.A. Liebhaber, and N.E. Cooke Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster Genome Res. 9 1999 581 587 (Pubitemid 29361275)
16. P.P. Minghetti, D.E. Ruffner, W.J. Kuang, O.E. Dennison, J.W. Hawkins, W.G. Beattie, and A. Dugaiczyk Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4 J. Biol. Chem. 261 1986 6747 6757 (Pubitemid 17219439)
17. L. Minchiotti, M. Galliano, G. Caridi, U. Kragh-Hansen, and T. Peters Jr. Congenital analbuminemia: molecular defects and biochemical and clinical aspects Biochim. Biophys. Acta 1830 2013 5494 5502
18. A.L. Tárnoky Genetic and drug-induced variation in serum albumin Adv. Clin. Chem. 21 1980 101 145 (this issue)
19. J.V. Neel, C. Satoh, K. Goriki, M. Fujita, N. Takahashi, J.-I. Asakawa, and R. Hazama The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides Proc. Natl. Acad. Sci. U. S. A. 83 1986 389 393 (Pubitemid 16080018)
20. J.V. Neel, C. Satoh, K. Goriki, J.-I. Asakawa, M. Fujita, N. Takahashi, T. Kageoka, and R. Hazama Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report Am. J. Hum. Genet. 42 1988 663 676
21. M. Galliano, L. Minchiotti, P. Iadarola, M. Stoppini, P. Giagnoni, S. Watkins, J. Madison, and F.W. Putnam Protein and DNA sequence analysis of a "private" genetic variant: albumin Ortonovo (Glu-505 → Lys) Biochim. Biophys. Acta 1225 1993 27 32 (Pubitemid 23348073)
22. S. Tara Devi, and R. Goyal Albumin variants in the Kannikar tribals of Nedumangard Taluk, Trivandrum District, Kerala (India) Anthrop. Anz. 49 1991 187 193
23. M.H.L.P. Franco, S.O. Brennan, E.K.M. Chua, U. Kragh-Hansen, S.M. Callegari-Jacques, M.Z.P.J. Bezerra, and F.M. Salzano Albumin genetic variability in South America: population distribution and molecular studies Am. J. Hum. Biol. 11 1999 359 366 (Pubitemid 129726306)
24. L. Minchiotti, M. Galliano, U. Kragh-Hansen, and T. Peters Jr. Mutations and polymorphisms of the gene of the major human blood protein, serum albumin Hum. Mutat. 29 2008 1007 1016
25. D. Bar-Or, R. Bar-Or, L.T. Rael, D.K. Gardner, D.S. Slone, and M.L. Craun Heterogeneity and oxidation status of commercial human albumin preparations in clinical use Crit. Care Med. 33 2005 1638 1641 (Pubitemid 40980625)
26. D. Bar-Or, L.T. Rael, R. Bar-Or, D.S. Slone, and M.L. Craun The formation and rapid clearance of a truncated albumin species in a critically ill patient Clin. Chim. Acta 365 2006 346 349 (Pubitemid 43196459)
27. S.O. Brennan, and P.M. George Three truncated forms of serum albumin associated with pancreatic pseudocyst Biochim. Biophys. Acta 1481 2000 337 343
28. R.D. Ireland, S.O. Brennan, J.A. Gerrard, T.A. Walmsley, P.M. George, and R.I. King A mass-spectroscopic method for measuring des-Leu albumin - a novel marker for chronic pancreatitis Clin. Biochem. 45 2012 1664 1668
29. K. Nakajou, H. Watanabe, U. Kragh-Hansen, T. Maruyama, and M. Otagiri The effect of glycation on the structure, function and biological fate of human serum albumin as revealed by recombinant mutants Biochim. Biophys. Acta 1623 2003 88 97 (Pubitemid 37315665)
30. S.O. Brennan, and K. Nakayama Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase FEBS Lett. 338 1994 147 151 (Pubitemid 24064954)
31. J.M. Fine, J.P. Allain, D. Rochu, and M. Marneux Occurrence of normal circulating proalbumin in a hemophilic A patient after acute hepatitis related to the delta virus Clin. Chem. 32 1986 1991 1993 (Pubitemid 17018088)
32. S.O. Brennan, J.M. Sheat, and M. Aiach Circulating proalbumin associated with a second case of antitrypsin Pittsburgh Clin. Chim. Acta 214 1993 123 128 (Pubitemid 23102283)
33. Y. Iwao, M. Hiraike, U. Kragh-Hansen, K. Kawai, A. Suenaga, T. Maruyama, and M. Otagiri Altered chain-length and glycosylation modify the pharmacokinetics of human serum albumin Biochim. Biophys. Acta 1794 2009 634 641
34. U. Kragh-Hansen, S. Saito, K. Nishi, M. Anraku, and M. Otagiri Effect of genetic variation on the thermal stability of human serum albumin Biochim. Biophys. Acta 1747 2005 81 88 (Pubitemid 40170455)
35. S.O. Brennan, and R.W. Carrell Functional abnormality of proalbumin Christchurch Biochim. Biophys. Acta 621 1980 83 88 (Pubitemid 10187228)
36. 2 + to natural mutants of human serum albumin and proalbumin Biochem. J. 301 1994 217 223 (Pubitemid 24214704)
37. N. Takahashi, Y. Takahashi, and F.W. Putnam Structural changes and metal binding by proalbumins and other amino-terminal genetic variants of human serum albumin Proc. Natl. Acad. Sci. U. S. A. 84 1987 7403 7407
38. S.O. Brennan, K. Arai, J. Madison, C.-B. Laurell, M. Galliano, S. Watkins, R. Peach, T. Myles, P. George, and F.W. Putnam Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene Proc. Natl. Acad. Sci. U. S. A. 87 1990 3909 3913
39. J. Carlson, Y. Sakamoto, C.-B. Laurell, J. Madison, S. Warkins, and F.W. Putnam Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants Proc. Natl. Acad. Sci. U. S. A. 89 1992 8225 8229
40. Y. Abdo, J. Rousseaux, and M. Dautrevaux Proalbumin Lille, a new variant of human serum albumin FEBS Lett. 131 1981 286 288 (Pubitemid 12231349)
41. Y. Matsuda, F. Ogushi, K. Ogawa, and N. Katunuma Structure and properties of albumin Tokushima and its proteolytic processing by Cathepsin B in vitro J. Biochem. 100 1986 375 379
42. W.-C. Zan, W.-F. Xu, and C.-W. Chi Protein and gene structure analysis of an albumin genetic variant: proalbumin Wu Yang (- 2 Arg → His) Int. J. Peptide Protein Res. 41 1993 441 446 (Pubitemid 23144738)
43. S.O. Brennan, and R.W. Carrell a circulating variant of human proalbumin Nature 274 1978 908 909 (Pubitemid 9004063)
44. J. Madison, K. Arai, Y. Sakamoto, R.D. Feld, R.A. Kyle, S. Watkins, E. Davis, Y.-I. Matsuda, I. Amaki, and F.W. Putnam Genetic variants of serum albumin in Americans and Japanese Proc. Natl. Acad. Sci. U. S. A. 88 1991 9853 9857 (Pubitemid 21915732)
45. U. Kragh-Hansen, M. Campagnoli, S. Dodig, H. Nielsen, B. Benko, M. Raos, R. Cesati, A. Sala, M. Galliano, and L. Minchiotti Structural analysis and fatty acid-binding properties of two Croatian variants of human serum albumin Clin. Chim. Acta 349 2004 105 112 (Pubitemid 39311995)
46. M. Galliano, L. Minchiotti, M. Stoppini, and A.L. Tárnoky A new proalbumin variant: albumin Jaffna (- 1 Arg → Leu) FEBS Lett. 255 1989 295 299 (Pubitemid 19234516)
47. S.O. Brennan, R.J. Peach, and D.R. Boswell Novel human proalbumin variant with intact dibasic sequence facilitates identification of its converting enzyme Biochim. Biophys. Acta 993 1989 48 50 (Pubitemid 19249310)
48. M. Galliano, U. Kragh-Hansen, A.L. Tárnoky, J.C. Chapman, M. Campagnoli, and L. Minchiotti Genetic variants showing apparent hot-spots in the human serum albumin gene Clin. Chim. Acta 289 1999 45 55 (Pubitemid 29505198)
49. J. Ghuman, P.A. Zunszain, I. Petitpas, A.A. Bhattacharya, M. Otagiri, and S. Curry Structural basis of the drug-binding specificity of human serum albumin J. Mol. Biol. 353 2005 38 52 (Pubitemid 41338838)
50. U. Kragh-Hansen, D. Donaldson, and P.H. Jensen The glycan structure of albumin Redhill, a glycosylated variant of human serum albumin Biochim. Biophys. Acta 1550 2001 20 26 (Pubitemid 33153061)
51. S.O. Brennan, T. Myles, R.J. Peach, D. Donaldson, and P.M. George Albumin Redhill (- 1Arg, 320Ala → Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site Proc. Natl. Acad. Sci. U. S. A. 87 1990 26 30
52. J. Madison, M. Galliano, S. Watkins, L. Minchiotti, F. Porta, A. Rossi, and F.W. Putnam Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant Proc. Natl. Acad. Sci. U. S. A. 91 1994 6476 6480 (Pubitemid 24200684)
53. M. Galliano, L. Minchiotti, F. Porta, A. Rossi, G. Ferri, J. Madison, S. Watkins, and F.W. Putnam Mutations in genetic variants of human serum albumin found in Italy Proc. Natl. Acad. Sci. U. S. A. 87 1990 8721 8725 (Pubitemid 120007580)
54. Y. Sakamoto, K. Kitamura, J. Madison, S. Watkins, C.-B. Laurell, M. Nomura, T. Higashiyama, and F.W. Putnam Structural study of the glycosylated and unglycosylated forms of a genetic variant of human serum albumin (63 Asp → Asn) Biochim. Biophys. Acta 1252 1995 209 216
55. T. Sunthornthepvarakul, S. Likitmaskul, S. Ngowngarmratana, K. Angsusingha, S. Kitvitayasak, N.H. Scherberg, and S. Refetoff Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect J. Clin. Endocrinol. Metab. 83 1998 1448 1454 (Pubitemid 28501001)
56. N. Takahashi, Y. Takahashi, T. Isobe, F.W. Putnam, M. Fujita, C. Satoh, and J.V. Neel Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations Proc. Natl. Acad. Sci. U. S. A. 84 1987 8001 8005 (Pubitemid 17162816)
57. F.W. Lorey, C.E. Ahlfors, D.G. Smith, and J.V. Neel Bilirubin binding by variant albumins in Yanomama Indians Am. J. Hum. Genet. 36 1984 1112 1120 (Pubitemid 15205741)
58. K. Arai, J. Madison, A. Shimizu, and F.W. Putnam Point substitutions in albumin genetic variants from Asia Proc. Natl. Acad. Sci. U. S. A. 87 1990 497 501
59. L. Minchiotti, S. Watkins, J. Madison, F.W. Putnam, U. Kragh-Hansen, A. Amoresano, P. Pucci, R. Cesati, and M. Galliano Structural characterization of four genetic variants of human serum albumin associated with alloalbuminemia in Italy Eur. J. Biochem. 247 1997 476 482 (Pubitemid 27308624)
60. Y. Iwao, M. Hiraike, U. Kragh-Hansen, K. Mera, T. Noguchi, M. Anraku, K. Kawai, T. Maruyama, and M. Otagiri Changes of net charge and α-helical content affect the pharmacokinetic properties of human serum albumin Biochim. Biophys. Acta 1774 2007 1582 1590 (Pubitemid 350235344)
61. L. Minchiotti, M. Galliano, U. Kragh-Hansen, S. Watkins, J. Madison, and F.W. Putnam A genetic variant of albumin (albumin Asola; Tyr140 → Cys) with no free -SH group but with an additional disulfide bridge Eur. J. Biochem. 228 1995 155 159
62. Y.-H. Kim, Y.-W. Lee, B.R. Jeon, Y.K. Lee, H.B. Shin, D.H. Kang, S.K. Park, D.S. Hong, S.-T. Lee, J.-W. Kim, and C.-S. Ki Clinical characteristics and ALB gene mutation analysis of Korean patients with bisalbuminemia Korean J. Lab. Med. 30 2010 307 311
63. S.O. Brennan, and A.P. Fellowes Albumin Hawkes Bay; a low level variant caused by loss of a sulfhydryl group at position 177 Biochim. Biophys. Acta 1182 1993 46 50 (Pubitemid 23233672)
64. C.E. Petersen, A.G. Scottolini, L.R. Cody, M. Mandel, N. Reimer, and N.V. Bhagavan A point mutation in the human serum albumin gene results in familial dysalbuminaemic hyperthyroxinaemia J. Med. Genet. 31 1994 355 359 (Pubitemid 24157246)
65. T. Sunthornthepvarakul, P. Angkeow, R.E. Weiss, Y. Hayashi, and S. Refetoff An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families Biochem. Biophys. Res. Commun. 29 1994 781 787
66. C.E. Petersen, C.-E. Ha, M. Mandel, and N.V. Bhagavan Expression of a human serum albumin variant with high affinity for thyroxine Biochem. Biophys. Res. Commun. 214 1995 1121 1129
67. C.E. Petersen, C.-E. Ha, K. Harohalli, D.S. Park, and N.V. Bhagavan Familial dysalbuminemic hyperthyroxinemia may result in altered warfarin pharmacokinetics Chem. Biol. Interact. 124 2000 161 172 (Pubitemid 30072750)
68. N. Wada, H. Chiba, C. Shimizu, H. Kijima, M. Kubo, and T. Koike A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred J. Clin. Endocrinol. Metab. 82 1997 3246 3250 (Pubitemid 27419065)
69. S. Pannain, M. Feldman, U. Eiholzer, R.E. Weiss, N.H. Scherberg, and S. Refetoff Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine J. Clin. Endocrinol. Metab. 85 2000 2786 2792 (Pubitemid 32269152)
70. L. Minchiotti, M. Galliano, M.C. Zapponi, and R. Tenni The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240 → Glu] albumin mutant Eur. J. Biochem. 214 1993 437 444 (Pubitemid 23173793)
71. O. Sugita, N. Endo, T. Yamada, M. Yakata, and S. Odani The molecular abnormality of albumin Niigata: 269 Asp → Gly Clin. Chim. Acta 164 1987 251 259 (Pubitemid 17083993)
72. K. Arai, J. Madison, K. Huss, N. Ishioka, C. Satoh, M. Fujita, J.V. Neel, I. Sakurabayashi, and F.W. Putnam Point substitutions in Japanese alloalbumins Proc. Natl. Acad. Sci. U. S. A. 86 1989 6092 6096 (Pubitemid 19210607)
73. U. Kragh-Hansen, L. Minchiotti, S.O. Brennan, and O. Sugita Hormone binding to natural mutants of human serum albumin Eur. J. Biochem. 193 1990 169 174 (Pubitemid 20331625)
74. M. Galliano, L. Minchiotti, P. Iadarola, M. Stoppini, G. Ferri, and A.A. Castellani The molecular defect of albumin Tagliacozzo: 313 Lys → Asn FEBS Lett. 208 1986 364 368
75. S.O. Brennan, and P. Herbert Albumin Canterbury (313 Lys → Asn). A point mutation in the second domain of serum albumin Biochim. Biophys. Acta 912 1987 191 197 (Pubitemid 17047819)
76. D. Savva, B. Li, U. Kragh-Hansen, M. Galliano, L. Minchiotti, and A.L. Tárnoky Genetic variation in human serum albumin: a 313 Lys → Asn mutation in Albumin Reading identified by PCR analysis Clin. Chim. Acta 270 1998 195 201 (Pubitemid 28095692)
77. U. Kragh-Hansen, S.O. Brennan, M. Galliano, and O. Sugita Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations Mol. Pharmacol. 37 1990 238 242 (Pubitemid 20082988)
78. L. Minchiotti, U. Kragh-Hansen, H. Nielsen, E. Hardy, A.-Y. Mercier, and M. Galliano Structural characterization, stability and fatty acid-binding properties of two French genetic variants of human serum albumin Biochim. Biophys. Acta 1431 1999 223 231 (Pubitemid 29182737)
79. S. Brand, D.W. Hutchinson, and D. Donaldson Albumin Redhill, a human albumin variant Clin. Chim. Acta 136 1984 197 202 (Pubitemid 14219617)
80. D.W. Hutchinson, and P. Matejtschuk The N-terminal sequence of albumin Redhill, a variant of human serum albumin FEBS Lett. 193 1985 211 212 (Pubitemid 16163984)
81. H. Nielsen, U. Kragh-Hansen, L. Minchiotti, M. Galliano, S.O. Brennan, A.L. Tárnoky, M.H.L.P. Franco, F.M. Salzano, and O. Sugita Effect of genetic variation on the fatty acid-binding properties of human serum albumin and proalbumin Biochim. Biophys. Acta 1342 1997 191 204 (Pubitemid 27490366)
82. M. Galliano, L. Minchiotti, P. Iadarola, G. Ferri, M.C. Zapponi, and A.A. Castellani The amino acid substitution in albumin Roma: 321 Glu → Lys FEBS Lett. 233 1988 100 104
83. L. Minchiotti, M. Galliano, M. Stoppini, G. Ferri, H. Crespeau, D. Rochu, and F. Porta Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions Biochim. Biophys. Acta 1119 1992 232 238
84. K. Arai, K. Huss, J. Madison, F.W. Putnam, F.M. Salzano, M.H.L.P. Franco, S.E.B. Santos, and M.J.M. Freitas Amino acid substitutions in albumin variants found in Brazil Proc. Natl. Acad. Sci. U. S. A. 86 1989 1821 1825 (Pubitemid 19087025)
85. M. Galliano, S. Watkins, J. Madison, F.W. Putnam, U. Kragh-Hansen, R. Cesati, and L. Minchiotti Structural characterization of three genetic variants of human serum albumin modified in subdomains IIB and IIIA Eur. J. Biochem. 251 1998 329 334 (Pubitemid 28080930)
86. S.O. Brennan The molecular abnormality of albumin Parklands: 365 Asp → His Biochim. Biophys. Acta 830 1985 320 324 (Pubitemid 15003683)
87. G. Caridi, M. Dagnino, A.-M. Simundic, M. Miler, V. Stancic, M. Campagnoli, M. Galliano, and L. Minchiotti Albumin Benkovac (c.1175 A>G; p.Glu392Gly): a novel genetic variant of human serum albumin Trans. Res. 155 2010 118 119
88. S.G. Franklin, S.I. Wolf, Y. Özdemir, G.T. Yüregir, T. Isbir, and B.S. Blumberg Albumin Naskapi variant in North American Indians and Eti Turks Proc. Natl. Acad. Sci. U. S. A. 77 1980 5480 5482 (Pubitemid 11249667)
89. M. Galliano, A. Rossi, F. Porta, and L. Minchiotti Genetic variants of human serum albumin: molecular defects and biological stability Int. J. Clin. Pharmacol. Res. 15 1995 45 55
90. Y. Ishima, T. Sawa, U. Kragh-Hansen, Y. Miyamoto, S. Matsushita, T. Akaike, and M. Otagiri S-nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties J. Pharmacol. Exp. Ther. 320 2007 969 977 (Pubitemid 46294047)
91. Y. Sakamoto, E. Davis, J. Madison, S. Watkins, H. McLaughlin, D.T. Leahy, and F.W. Putnam Purification and structural study of two albumin variants in an Irish population Clin. Chim. Acta 204 1991 179 188
92. R.J. Peach, and S.O. Brennan Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp → Asn) Biochim. Biophys. Acta 1097 1991 49 54
93. D. Savva, A.L. Tárnoky, and M.F. Vickers Genetic characterization of an alloalbumin, albumin Kashmir, using gene amplification and allele-specific oligonucleotides Biochem. J. 266 1990 615 617 (Pubitemid 20090169)
94. L. Minchiotti, M. Galliano, P. Iadarola, E. Zepponi, and G. Ferri The molecular defect of albumin Castel di Sangro: 536 Lys → Glu Biochim. Biophys. Acta 1039 1990 204 208 (Pubitemid 20183606)
95. N. Takahashi, Y. Takahashi, B.S. Blumberg, and F.W. Putnam Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning Proc. Natl. Acad. Sci. U. S. A. 84 1987 4413 4417 (Pubitemid 17097843)
96. E.K.M. Chua, S.O. Brennan, and P.M. George Albumin Church Bay: 560 Lys → Glu a new mutation detected by electrospray ionization spectrometry Biochim. Biophys. Acta 1382 1998 305 310 (Pubitemid 28130402)
97. W.P. Winter, L.R. Weitkamp, and D.L. Rucknagel Amino acid substitution in two identical inherited human serum albumin variants: Albumin Oliphant and Albumin Ann Arbor Biochemistry 11 1972 889 896
98. L. Minchiotti, M. Galliano, P. Iadarola, M. Stoppini, G. Ferri, and A.A. Castellani Structural characterization of two genetic variants of human serum albumin Biochim. Biophys. Acta 916 1987 411 418 (Pubitemid 18016732)
99. R.J. Peach, A.P. Fellowes, S.O. Brennan, and P.M. George Albumin Rugby Park: a truncated albumin variant caused by a G → C splice-site mutation in intron 13 Biochim. Biophys. Acta 1180 1992 107 110
100. S.O. Brennan, A.P. Fellowes, and P.M. George Albumin Banks Peninsula: a new termination variant characterized by electrospray mass spectrometry Biochim. Biophys. Acta 1433 1999 321 326 (Pubitemid 29369066)
101. P. Iadarola, L. Minchiotti, and M. Galliano Localization of the amino acid substitution site in a fast migrating variant of human serum albumin FEBS Lett. 180 1985 85 88 (Pubitemid 15170944)
102. L. Minchiotti, M. Campagnoli, A. Rossi, M.E. Cosulich, M. Monti, P. Pucci, U. Kragh-Hansen, B. Granel, P. Disdier, P.J. Weiller, and M. Galliano A nucleotide insertion and frameshift cause albumin Kénitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges Eur. J. Biochem. 268 2001 344 352 (Pubitemid 32862665)
103. M. Galliano, L. Minchiotti, P. Iadarola, M.C. Zapponi, G. Ferri, and A.A. Castellani Structural characterization of a chain termination mutant of human serum albumin J. Biol. Chem. 261 1986 4283 4287 (Pubitemid 17198869)
104. S. Watkins, J. Madison, E. Davis, Y. Sakamoto, M. Galliano, L. Minchiotti, and F.W. Putnam A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin Proc. Natl. Acad. Sci. U. S. A. 88 1991 5959 5963 (Pubitemid 21914865)
105. L. Minchiotti, M. Galliano, P. Iadarola, M.L. Meloni, G. Ferri, F. Porta, and A.A. Castellani The molecular defect in a COOH-terminal-modified and shortened mutant of human serum albumin J. Biol. Chem. 264 1989 3385 3389 (Pubitemid 19063395)
106. J.T. Andersen, M.B. Daba, and I. Sandlie FcRn binding properties of an abnormal truncated analbuminemic albumin variant Clin. Biochem. 43 2010 367 372
107. J.T. Andersen, B. Dalhus, J. Cameron, M.B. Daba, A. Plumridge, L. Evans, S.O. Brennan, K.S. Gunnarsen, M. Bjørås, D. Sleep, and I. Sandlie Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor Nat. Commun. 3 2012 610 10.1038/nocmms1607
108. J.T. Andersen, and I. Sandlie The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics Drug Metab. Pharmacokinet. 24 2009 318 332
109. C.E. Petersen, C.-E. Ha, K. Harohalli, D. Park, and N.V. Bhagavan Mutagenesis studies of thyroxine binding to human serum albumin define an important structural characteristic of subdomain 2A Biochemistry 36 1997 7012 7017 (Pubitemid 27258114)
110. I. Petitpas, C.E. Petersen, C.-E. Ha, A.A. Bhattacharya, P.A. Zunszain, J. Ghuman, N.V. Bhagavan, and S. Curry Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia Proc. Natl. Acad. Sci. U. S. A. 100 2003 6440 6445 (Pubitemid 36666600)
111. U. Kragh-Hansen, A.O. Pedersen, M. Galliano, L. Minchiotti, S.O. Brennan, A.L. Tárnoky, M.H.L.P. Franco, and F.M. Salzano High-affinity binding of laurate to naturally occurring mutants of human serum albumin and proalbumin Biochem. J. 320 1996 911 916 (Pubitemid 27013809)
112. U. Kragh-Hansen, H. Watanabe, K. Nakajou, Y. Iwao, and M. Otagiri Chain length-dependent binding of fatty acid anions to human serum albumin studied by site-directed mutagenesis J. Mol. Biol. 363 2006 702 712 (Pubitemid 44486220)
113. K.A. Majorek, P.J. Porebski, A. Dayal, M.D. Zimmerman, K. Jablonska, A.J. Stewart, M. Chruszcz, and W. Minor Structural and immunologic characterization of bovine, horse, and rabbit serum albumins Mol. Immunol. 52 2012 174 182
114. C.A. Blindauer, I. Harvey, K.E. Bunyan, A.J. Stewart, D. Sleep, D.J. Harrison, S. Berezenko, and P.J. Sadler Structure, properties, and engineering of the major zinc binding site on human albumin J. Biol. Chem. 284 2009 23116 23124
115. K. Vestberg, M. Galliano, L. Minchiotti, and U. Kragh-Hansen High-affinity binding of warfarin, salicylate and diazepam to natural mutants of human serum albumin modified in the C-terminal end Biochem. Pharmacol. 44 1992 1515 1521
116. H. Watanabe, U. Kragh-Hansen, S. Tanase, K. Nakajou, M. Mitarai, Y. Iwao, T. Maruyama, and M. Otagiri Conformational stability and warfarin-binding properties of human serum albumin studied by recombinant mutants Biochem. J. 357 2001 269 274 (Pubitemid 32642926)
117. Y. Iwao, M. Anraku, K. Yamasaki, U. Kragh-Hansen, K. Kawai, T. Maruyama, and M. Otagiri Oxidation of Arg-410 promotes the elimination of human serum albumin Biochim. Biophys. Acta 1764 2006 743 749
118. K. Hirata, T. Maruyama, H. Watanabe, H. Maeda, K. Nakajou, Y. Iwao, Y. Ishima, H. Katsumi, M. Hashida, and M. Otagiri Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics J. Control. Release 145 2010 9 16
119. K.-T. Tang, H.-J. Yang, K.-B. Choo, H.-D. Lin, S.-L. Fang, and L.E. Braverman A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia Eur. J. Endocrinol. 141 1999 374 378 (Pubitemid 29529491)
120. S.C. Tiu, K.L. Choi, C.C. Shek, and T.C. Lau A Chinese family with familial dysalbuminaemic hyperthyroxinaemia Hong Kong Med. J. 9 2003 464 467 (Pubitemid 37553369)
121. A. Bellomo, M. Mancinella, G. Troisi, and V. Marigliano A rare familiar case of hereditary bisalbuminemia and diabetic predisposition: a possible predictive link? Arch. Gerontol. Geriatr. 50 2010 345 346
122. G. Kalambokis, M. Kitsanou, C. Kalogera, G. Kolios, K. Seferiadis, and E. Tsianos Inherited bisalbuminemia with benign monoclonal gammopathy detected by capillary but not agarose gel electrophoresis Clin. Chem. 48 2002 2076 2077 (Pubitemid 35222776)
123. G. Srikrishna, D. Mathai, O.C. Abraham, A. Kaur, A.S. Kanagasabapathy, and B.M. Pulimood IgG multiple myeloma and alloalbuminemia: as unusual association J. Assoc. Physicians India 42 1994 331 332
124. A.-M. Simundic, M. Miler, N. Nikolac, E. Topic, D. Carzavec, B. Milanovic, and V. Stancic Bisalbuminemia in a male Croatian patient with sarcoidosis Biochem. Med. 19 2009 95 100
125. A.A. Ejaz, M. Krishna, A. Wasiluk, and J.D. Knight Bisalbuminemia in chronic kidney disease Clin. Exp. Nephrol. 8 2004 270 273 (Pubitemid 39421379)
126. J. Ahmad, A.S. Khan, M.A. Siddiqui, S.G. Tewari, and R.U. Khan Bisalbuminemia in nephrotic syndrome (a case report) Jpn. J. Med. 23 1984 45 47 (Pubitemid 14029445)
127. M.P. Hoang, L.B. Baskin, and F.H. Wians Jr. Bisalbuminuria in an adult with bisalbuminemia and nephrotic syndrome Clin. Chim. Acta 284 1999 101 107 (Pubitemid 29324870)
128. J.K. Shetty, M. Prakash, and K. Gopalakrishna Bisalbuminemia in an adult male with Alzheimer's disease Indian J. Med. Sci. 61 2007 356 357 (Pubitemid 46897228)
129. S.R. Mitzner Extracorporeal liver support-albumin dialysis with the Molecular Adsorbent Recirculating System (MARS) Ann. Hepatol. 10 Suppl. 1 2011 S21 S28
130. Y. Ishima, F. Yoshida, U. Kragh-Hansen, K. Watanabe, N. Katayama, K. Nakajou, T. Akaike, T. Kai, T. Maruyama, and M. Otagiri Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin Free Radic. Res. 45 2011 1196 1206
131. Y. Ishima, M. Hara, U. Kragh-Hansen, A. Inoue, A. Suenaga, T. Kai, H. Watanabe, M. Otagiri, and T. Maruyama Elucidation of the therapeutic enhancer mechanism of poly-S-nitrosated human serum albumin against multidrug-resistant tumor in animal models J. Control. Release 164 2012 1 7