메뉴 건너뛰기




Volumn 195, Issue , 2015, Pages 100-111

Synergic and antagonistic effect of small hairpin RNAs targeting the NS gene of the influenza A virus in cells and mice

Author keywords

Influenza virus; NEP protein; NS1 protein; ShRNA

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; MESSENGER RNA; RETINOIC ACID INDUCIBLE PROTEIN I; SHORT HAIRPIN RNA; ANTIVIRUS AGENT; NS PROTEIN, INFLUENZA VIRUS; SMALL INTERFERING RNA; VIRUS PROTEIN;

EID: 84919360160     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2014.08.004     Document Type: Article
Times cited : (9)

References (59)
  • 1
    • 0033838456 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus
    • Aragón T., de la Luna S., Novoa I., Carrasco L., Ortín J., Nieto A. Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol. Cell. Biol. 2000, 20:6259-6268.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6259-6268
    • Aragón, T.1    de la Luna, S.2    Novoa, I.3    Carrasco, L.4    Ortín, J.5    Nieto, A.6
  • 3
    • 84880364434 scopus 로고    scopus 로고
    • Role and application of RNA interference in replication of influenza viruses
    • Betakova T., Svancarova P. Role and application of RNA interference in replication of influenza viruses. Acta Virol. 2013, 5:97-104.
    • (2013) Acta Virol. , vol.5 , pp. 97-104
    • Betakova, T.1    Svancarova, P.2
  • 4
    • 80054775532 scopus 로고    scopus 로고
    • Pooled lentiviral shRNA screening for functional genomics in mammalian cells
    • Blakely K., Ketela T., Moffat J. Pooled lentiviral shRNA screening for functional genomics in mammalian cells. Methods Mol. Biol. 2011, 781:161-182.
    • (2011) Methods Mol. Biol. , vol.781 , pp. 161-182
    • Blakely, K.1    Ketela, T.2    Moffat, J.3
  • 5
    • 17244362716 scopus 로고    scopus 로고
    • Combination of small interfering RNAs mediates greater inhibition of human hepatitis B virus replication and antigen expression
    • Chen Z., Xu Z.F., Ye J.J., Yao H.P., Zheng S., Ding J.Y. Combination of small interfering RNAs mediates greater inhibition of human hepatitis B virus replication and antigen expression. J. Zhejiang Univ. Sci. B 2005, 6:236-241.
    • (2005) J. Zhejiang Univ. Sci. B , vol.6 , pp. 236-241
    • Chen, Z.1    Xu, Z.F.2    Ye, J.J.3    Yao, H.P.4    Zheng, S.5    Ding, J.Y.6
  • 6
    • 0345167006 scopus 로고    scopus 로고
    • A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
    • Donelan N.R., Basler C.F., García-Sastre A. A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J. Virol. 2003, 77:13257-13266.
    • (2003) J. Virol. , vol.77 , pp. 13257-13266
    • Donelan, N.R.1    Basler, C.F.2    García-Sastre, A.3
  • 8
    • 0037418322 scopus 로고    scopus 로고
    • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    • Ge Q., McManus M.T., Nguyen T., Shen C.H., Sharp P.A., Eisen H.N., Chen J. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:2718-2723.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 2718-2723
    • Ge, Q.1    McManus, M.T.2    Nguyen, T.3    Shen, C.H.4    Sharp, P.A.5    Eisen, H.N.6    Chen, J.7
  • 9
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • Ge Q., Filip L., Bai A., Nguyen T., Eisen H.N., Chen J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:8676-8681.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 8676-8681
    • Ge, Q.1    Filip, L.2    Bai, A.3    Nguyen, T.4    Eisen, H.N.5    Chen, J.6
  • 10
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A., Pasquinelli A.E., Conte D., Li N., Parrish S., Ha I., Baillie D.L., Fire A., Ruvkun G., Mello C.C. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 2001, 106:23-34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 11
    • 55749101028 scopus 로고    scopus 로고
    • A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene
    • Gobeil S., Zhu X., Doillon C.J., Green M.R. A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev. 2008, 22:2932-2940.
    • (2008) Genes Dev. , vol.22 , pp. 2932-2940
    • Gobeil, S.1    Zhu, X.2    Doillon, C.J.3    Green, M.R.4
  • 13
    • 0027102716 scopus 로고
    • Binding of influenza A virus NS1 protein to dsRNA in vitro
    • Hatada E., Fukuda R. Binding of influenza A virus NS1 protein to dsRNA in vitro. J. Gen. Virol. 1992, 73:3325-3329.
    • (1992) J. Gen. Virol. , vol.73 , pp. 3325-3329
    • Hatada, E.1    Fukuda, R.2
  • 14
    • 0030982614 scopus 로고    scopus 로고
    • Binding of the influenza virus NS1 protein to model genome RNAs
    • Hatada E., Saito S., Okishio N., Fukuda R. Binding of the influenza virus NS1 protein to model genome RNAs. J. Gen. Virol. 1997, 78:1059-1063.
    • (1997) J. Gen. Virol. , vol.78 , pp. 1059-1063
    • Hatada, E.1    Saito, S.2    Okishio, N.3    Fukuda, R.4
  • 15
    • 67449097020 scopus 로고    scopus 로고
    • The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells
    • Haye K., Burmakina S., Moran T., García-Sastre A., Fernandez-Sesma A. The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. J. Virol. 2009, 83:6849-6862.
    • (2009) J. Virol. , vol.83 , pp. 6849-6862
    • Haye, K.1    Burmakina, S.2    Moran, T.3    García-Sastre, A.4    Fernandez-Sesma, A.5
  • 16
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G., McLachlan J., Pasquinelli A.E., Balint E., Tuschl T., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001, 293:834-838.
    • (2001) Science , vol.293 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 18
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting R.F., Fischer S.E., Bernstein E., Sijen T., Hannon G.J., Plasterk R.H. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 2001, 15:2654-2659.
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 19
    • 70349309765 scopus 로고    scopus 로고
    • Transcriptional gene silencing using small RNAs
    • Kim D.H., Rossi J.J. Transcriptional gene silencing using small RNAs. Methods Mol. Biol. 2009, 555:119-125.
    • (2009) Methods Mol. Biol. , vol.555 , pp. 119-125
    • Kim, D.H.1    Rossi, J.J.2
  • 20
    • 34250810666 scopus 로고    scopus 로고
    • Multiple anti-interferon actions of the influenza A virus NS1 protein
    • Kochs G., García-Sastre A., Martínez-Sobrido L. Multiple anti-interferon actions of the influenza A virus NS1 protein. J. Virol. 2007, 81:7011-7021.
    • (2007) J. Virol. , vol.81 , pp. 7011-7021
    • Kochs, G.1    García-Sastre, A.2    Martínez-Sobrido, L.3
  • 22
    • 81155159662 scopus 로고    scopus 로고
    • Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene
    • Li W., Yang X., Jiang Y., Wang B., Yang Y., Jiang Z., Li M. Inhibition of influenza A virus replication by RNA interference targeted against the PB1 subunit of the RNA polymerase gene. Arch. Virol. 2011, 156:1979-1987.
    • (2011) Arch. Virol. , vol.156 , pp. 1979-1987
    • Li, W.1    Yang, X.2    Jiang, Y.3    Wang, B.4    Yang, Y.5    Jiang, Z.6    Li, M.7
  • 23
    • 84869013254 scopus 로고    scopus 로고
    • 5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation
    • Lin L., Liu Q., Berube N., Detmer S., Zhou Y. 5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation. J. Virol. 2012, 86:10359-10369.
    • (2012) J. Virol. , vol.86 , pp. 10359-10369
    • Lin, L.1    Liu, Q.2    Berube, N.3    Detmer, S.4    Zhou, Y.5
  • 25
    • 0028040760 scopus 로고
    • The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing
    • Lu Y., Qian X.Y., Krug R.M. The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev. 1994, 8:1817-1828.
    • (1994) Genes Dev. , vol.8 , pp. 1817-1828
    • Lu, Y.1    Qian, X.Y.2    Krug, R.M.3
  • 26
    • 79960148982 scopus 로고    scopus 로고
    • Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
    • Martin J.N., Wolken N., Brown T., Dauer W.T., Ehrlich M.E., Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy 2011, 18:666-673.
    • (2011) Gene Therapy , vol.18 , pp. 666-673
    • Martin, J.N.1    Wolken, N.2    Brown, T.3    Dauer, W.T.4    Ehrlich, M.E.5    Gonzalez-Alegre, P.6
  • 27
    • 84871007119 scopus 로고    scopus 로고
    • Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
    • Mänz B., Brunotte L., Reuther P., Schwemmle M. Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells. Nat. Commun. 2012, 3:802.
    • (2012) Nat. Commun. , vol.3 , pp. 802
    • Mänz, B.1    Brunotte, L.2    Reuther, P.3    Schwemmle, M.4
  • 28
    • 84877784365 scopus 로고    scopus 로고
    • Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation
    • McCaskill J.L., Marsh G.A., Monaghan P., Wang L.F., Doran T., McMillan N.A. Potent inhibition of Hendra virus infection via RNA interference and poly I:C immune activation. PLOS ONE 2013, 8:e64360.
    • (2013) PLOS ONE , vol.8 , pp. e64360
    • McCaskill, J.L.1    Marsh, G.A.2    Monaghan, P.3    Wang, L.F.4    Doran, T.5    McMillan, N.A.6
  • 29
    • 34247566514 scopus 로고    scopus 로고
    • A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis
    • Min J.Y., Li S., Sen G.C., Krug R.M. A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology 2007, 36:236-243.
    • (2007) Virology , vol.36 , pp. 236-243
    • Min, J.Y.1    Li, S.2    Sen, G.C.3    Krug, R.M.4
  • 31
    • 0032086357 scopus 로고    scopus 로고
    • Influenza virus NS1 protein interacts with the cellular 30kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs
    • Nemeroff M.E., Barabino S.M., Li Y., Keller W., Krug R.M. Influenza virus NS1 protein interacts with the cellular 30kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol. Cell 1998, 1:991-1000.
    • (1998) Mol. Cell , vol.1 , pp. 991-1000
    • Nemeroff, M.E.1    Barabino, S.M.2    Li, Y.3    Keller, W.4    Krug, R.M.5
  • 32
    • 0032472328 scopus 로고    scopus 로고
    • The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins
    • O'Neill R.E., Talon J., Palese P. The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. EMBO J. 1998, 17:288-296.
    • (1998) EMBO J. , vol.17 , pp. 288-296
    • O'Neill, R.E.1    Talon, J.2    Palese, P.3
  • 33
    • 0028880783 scopus 로고
    • Translational control by influenza virus: identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation
    • Park Y.W., Katze M.G. Translational control by influenza virus: identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. J. Biol. Chem. 1995, 270:28433-28439.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28433-28439
    • Park, Y.W.1    Katze, M.G.2
  • 34
    • 84872028152 scopus 로고    scopus 로고
    • Emerging roles for the influenza A virus nuclear export protein (NEP)
    • Paterson D., Fodor E. Emerging roles for the influenza A virus nuclear export protein (NEP). PLOS Pathog. 2012, 8:e1003019.
    • (2012) PLOS Pathog. , vol.8 , pp. e1003019
    • Paterson, D.1    Fodor, E.2
  • 35
    • 84876833883 scopus 로고    scopus 로고
    • Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells
    • Pothlichet J., Meunier I., Davis B.K., Ting J.P., Skamene E., von Messling V., Vidal S.M. Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells. PLoS Pathog. 2013, 9:e1003256.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003256
    • Pothlichet, J.1    Meunier, I.2    Davis, B.K.3    Ting, J.P.4    Skamene, E.5    von Messling, V.6    Vidal, S.M.7
  • 36
    • 0029400032 scopus 로고
    • An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure
    • Qian X.Y., Chien C.Y., Lu Y., Montelione G.T., Krug R.M. An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure. RNA 1995, 1:948-956.
    • (1995) RNA , vol.1 , pp. 948-956
    • Qian, X.Y.1    Chien, C.Y.2    Lu, Y.3    Montelione, G.T.4    Krug, R.M.5
  • 37
    • 0028274131 scopus 로고
    • The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)
    • Qiu Y., Krug R.M. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J. Virol. 1994, 68:2425-2432.
    • (1994) J. Virol. , vol.68 , pp. 2425-2432
    • Qiu, Y.1    Krug, R.M.2
  • 38
    • 0029295578 scopus 로고
    • The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing
    • Qiu Y., Nemeroff M., Krug R.M. The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing. RNA 1995, 1:304-316.
    • (1995) RNA , vol.1 , pp. 304-316
    • Qiu, Y.1    Nemeroff, M.2    Krug, R.M.3
  • 39
    • 84870492545 scopus 로고    scopus 로고
    • Small interfering RNA targeting the nonstructural gene 1 transcript inhibits influenza A virus replication in experimental mice
    • Rajput R., Khanna M., Kumar P., Kumar B., Sharma S., Gupta N., Saxena L. Small interfering RNA targeting the nonstructural gene 1 transcript inhibits influenza A virus replication in experimental mice. Nucleic Acid Ther. 2012, 22:414-422.
    • (2012) Nucleic Acid Ther. , vol.22 , pp. 414-422
    • Rajput, R.1    Khanna, M.2    Kumar, P.3    Kumar, B.4    Sharma, S.5    Gupta, N.6    Saxena, L.7
  • 40
    • 84863836137 scopus 로고    scopus 로고
    • Down-regulation of viral replication by lentiviral-mediated expression of short-hairpin RNAs against vesicular stomatitis virus ribonuclear complex genes
    • Ramirez-Carvajal L., Long C.R. Down-regulation of viral replication by lentiviral-mediated expression of short-hairpin RNAs against vesicular stomatitis virus ribonuclear complex genes. Antiviral Res. 2012, 95:150-158.
    • (2012) Antiviral Res. , vol.95 , pp. 150-158
    • Ramirez-Carvajal, L.1    Long, C.R.2
  • 41
    • 0025924358 scopus 로고
    • NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells
    • Richardson J.C., Akkina R.K. NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells. Arch. Virol. 1991, 116:69-80.
    • (1991) Arch. Virol. , vol.116 , pp. 69-80
    • Richardson, J.C.1    Akkina, R.K.2
  • 42
    • 67649227447 scopus 로고    scopus 로고
    • NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome
    • Robb N.C., Smith M., Vreede F.T., Fodor E. NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J. Gen. Virol. 2009, 90:1398-1407.
    • (2009) J. Gen. Virol. , vol.90 , pp. 1398-1407
    • Robb, N.C.1    Smith, M.2    Vreede, F.T.3    Fodor, E.4
  • 44
    • 77953832371 scopus 로고    scopus 로고
    • Silencing of gene expression in cultured cells using small interfering RNAs
    • Sakurai K., Chomchan P., Rossi J.J. Silencing of gene expression in cultured cells using small interfering RNAs. Curr. Protoc. Cell Biol. 2010, 27:1-28.
    • (2010) Curr. Protoc. Cell Biol. , vol.27 , pp. 1-28
    • Sakurai, K.1    Chomchan, P.2    Rossi, J.J.3
  • 45
    • 17044461400 scopus 로고    scopus 로고
    • Generation of influenza transfectants using purified recombinant nucleocapsid protein
    • Shaw M.W., Kiseleva I.V., Egorov A.Y., Hemphill M.L., Xu X. Generation of influenza transfectants using purified recombinant nucleocapsid protein. J. Virol. Methods 1998, 76:149-151.
    • (1998) J. Virol. Methods , vol.76 , pp. 149-151
    • Shaw, M.W.1    Kiseleva, I.V.2    Egorov, A.Y.3    Hemphill, M.L.4    Xu, X.5
  • 46
    • 77649175477 scopus 로고    scopus 로고
    • Competition between siRNA duplexes: impact of RNA-induced silencing complex loading efficiency and comparison between conventional-21bp and dicer-substrate siRNAs
    • Tanudji M., Machalek D., Arndt G.M., Rivory L. Competition between siRNA duplexes: impact of RNA-induced silencing complex loading efficiency and comparison between conventional-21bp and dicer-substrate siRNAs. Oligonucleotides 2010, 20:27-32.
    • (2010) Oligonucleotides , vol.20 , pp. 27-32
    • Tanudji, M.1    Machalek, D.2    Arndt, G.M.3    Rivory, L.4
  • 47
    • 2942620143 scopus 로고    scopus 로고
    • Protection against lethal influenza virus challenge by RNA interference in vivo
    • Tompkins S.M., Lo C.Y., Tumpey T.M., Epstein S.L. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:8682-8686.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 8682-8686
    • Tompkins, S.M.1    Lo, C.Y.2    Tumpey, T.M.3    Epstein, S.L.4
  • 48
    • 69449084854 scopus 로고    scopus 로고
    • Differential RNA silencing suppression activity of NS1 proteins from different influenza A virus strains
    • de Vries W., Haasnoot J., Fouchier R., de Haan P., Berkhout B. Differential RNA silencing suppression activity of NS1 proteins from different influenza A virus strains. J. Gen. Virol. 2009, 90:1916-1922.
    • (2009) J. Gen. Virol. , vol.90 , pp. 1916-1922
    • de Vries, W.1    Haasnoot, J.2    Fouchier, R.3    de Haan, P.4    Berkhout, B.5
  • 50
    • 67749133883 scopus 로고    scopus 로고
    • A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA
    • Wise H.M., Foeglein A., Sun J., Dalton R.M., Patel S., Howard W., Anderson E.C., Barclay W.S., Digard P. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J. Virol. 2009, 83:8021-8031.
    • (2009) J. Virol. , vol.83 , pp. 8021-8031
    • Wise, H.M.1    Foeglein, A.2    Sun, J.3    Dalton, R.M.4    Patel, S.5    Howard, W.6    Anderson, E.C.7    Barclay, W.S.8    Digard, P.9
  • 53
    • 36249003925 scopus 로고    scopus 로고
    • Inhibition of highly pathogenic avian H5N1 influenza virus replication by RNA oligonucleotides targeting NS1 gene
    • Wu Y., Zhang G., Li Y., Jin Y., Dale R., Sun L.Q., Wang M. Inhibition of highly pathogenic avian H5N1 influenza virus replication by RNA oligonucleotides targeting NS1 gene. Biochem. Biophys. Res. Commun. 2008, 365:369-374.
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 369-374
    • Wu, Y.1    Zhang, G.2    Li, Y.3    Jin, Y.4    Dale, R.5    Sun, L.Q.6    Wang, M.7
  • 54
    • 0027236576 scopus 로고
    • Molecular assembly of influenza virus: association of the NS2 protein with virion matrix
    • Yasuda J., Nakada S., Kato A., Toyoda T., Ishihama A. Molecular assembly of influenza virus: association of the NS2 protein with virion matrix. Virology 1993, 196:249-255.
    • (1993) Virology , vol.196 , pp. 249-255
    • Yasuda, J.1    Nakada, S.2    Kato, A.3    Toyoda, T.4    Ishihama, A.5
  • 55
    • 70449724590 scopus 로고    scopus 로고
    • Inhibition of highly pathogenic avian influenza virus H5N1 replication by the small interfering RNA targeting polymerase A gene
    • Zhang W., Wang C.Y., Yang S.T., Qin C., Hu J.L., Xia X.Z. Inhibition of highly pathogenic avian influenza virus H5N1 replication by the small interfering RNA targeting polymerase A gene. Biochem. Biophys. Res. Commun. 2009, 390:421-426.
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 421-426
    • Zhang, W.1    Wang, C.Y.2    Yang, S.T.3    Qin, C.4    Hu, J.L.5    Xia, X.Z.6
  • 56
    • 84902213434 scopus 로고    scopus 로고
    • Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus
    • Zhang S., Sun Y., Chen H., Day Y., Zhang Y., Yu S., Qiu X., Tan L., Song C., Ding Ch. Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus. Virol. J. 2014, 11:62. 10.1186/1743-422X-11-62.
    • (2014) Virol. J. , vol.11 , pp. 62
    • Zhang, S.1    Sun, Y.2    Chen, H.3    Day, Y.4    Zhang, Y.5    Yu, S.6    Qiu, X.7    Tan, L.8    Song, C.9    Ding, C.10
  • 59
    • 34548637012 scopus 로고    scopus 로고
    • Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice
    • Zhou H., Jin M., Yu Z., Xu X., Peng Y., Wu H., Liu J., Liu H., Cao S., Chen H. Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice. Antiviral Res 2007, 76:186-193.
    • (2007) Antiviral Res , vol.76 , pp. 186-193
    • Zhou, H.1    Jin, M.2    Yu, Z.3    Xu, X.4    Peng, Y.5    Wu, H.6    Liu, J.7    Liu, H.8    Cao, S.9    Chen, H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.