Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 50, 2014, Pages 18019-18024

  Devito, Stefanie Renee ^a   Ortiz Riaño, Emilio ^a   Martínez Sobrido, Luis ^a   Munger, Joshua ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cytomegalovirus; Glycosylation; Metabolism; Pyrimidine; UDP sugar

Indexed keywords

GLYCOPROTEIN B; LEFLUNOMIDE; PYRIMIDINE; SPARFOSIC ACID; SUGAR; URIDINE DIPHOSPHATE; PRIMER DNA; PYRIMIDINE DERIVATIVE; URIDINE DIPHOSPHATE SUGAR; VIRUS ENVELOPE PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; CORONAVIRUS INFECTION; CULTURE MEDIUM; CYTOMEGALOVIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; INFLUENZA A; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; NUCLEOTIDE METABOLISM; PROTEIN GLYCOSYLATION; PYRIMIDINE SYNTHESIS; RHABDOVIRUS INFECTION; VESICULAR STOMATITIS VIRUS; VIRION; VIROGENESIS; VIRUS INHIBITION; ANALYSIS OF VARIANCE; BIOSYNTHESIS; CYTOMEGALOVIRUS; GENETICS; GLYCOSYLATION; LIQUID CHROMATOGRAPHY; METABOLIC FLUX ANALYSIS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; VIRUS REPLICATION;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; MURINE HEPATITIS VIRUS; VESICULAR STOMATITIS VIRUS;

ANALYSIS OF VARIANCE; CHROMATOGRAPHY, LIQUID; CYTOMEGALOVIRUS; DNA PRIMERS; GLYCOSYLATION; HUMANS; METABOLIC FLUX ANALYSIS; PYRIMIDINES; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY; URIDINE DIPHOSPHATE SUGARS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 84919343869     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415864111     Document Type: Article

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