P53 prevents neurodegeneration by regulating synaptic genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 50, 2014, Pages 18055-18060

  Merlo, Paola ^a   Frost, Bess ^a   Peng, Shouyong ^a,b   Yang, Yawei J ^c,d,e   Park, Peter J ^b,f   Feany, Mel ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f Harvard Medical School Center for Biomedical Informatics   (United States)

Author keywords

ChIP chip; Neurodegeneration; P53 transcriptional function; Synaptic genes; Tauopathy

Indexed keywords

AMPHIPHYSIN; CLATHRIN HEAVY CHAIN; CLATHRIN LIGHT CHAIN; CYCLINE; PROTEIN P53; RAS PROTEIN; SYNAPTOTAGMIN; SYNAPTOTAGMIN BETA; TAU PROTEIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; P53 PROTEIN, DROSOPHILA;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE REGULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE TARGETING; GENETIC REGULATION; GENOME ANALYSIS; IN VIVO STUDY; MITOSIS; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; TAUOPATHY; ANIMAL; CELL AGING; CYTOLOGY; DNA DAMAGE; DROSOPHILA; GENE ONTOLOGY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SYNAPSE; TAUOPATHIES; WESTERN BLOTTING;

MAMMALIA;

ANIMALS; BLOTTING, WESTERN; CELL AGING; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GENE ONTOLOGY; IMMUNOHISTOCHEMISTRY; NEURONS; SYNAPSES; TAU PROTEINS; TAUOPATHIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84919340613     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419083111     Document Type: Article

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