Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice

European Journal of Pharmacology

Volumn 747, Issue , 2015, Pages 59-70

  Wang, Ming Xing ^a   Liu, Yang Liu ^a   Yang, Ying ^a   Zhang, Dong Mei ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Hyperuricemia; NF B; NLRP3 inflammasome; Nuciferine; Organic ion transporters; TLR signaling

Indexed keywords

ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; NUCIFERINE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OTERACIL POTASSIUM; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; APORPHINE DERIVATIVE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; ORGANIC ANION TRANSPORTER; OTERACIL; TLR4 PROTEIN, MOUSE; URATE TRANSPORTER; URIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FUNCTIONAL ASSESSMENT; HUMAN; HUMAN CELL; HYPERURICEMIA; IN VITRO STUDY; KIDNEY FUNCTION; MALE; MOUSE; NEPHRITIS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BLOOD; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; INTESTINE; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; APORPHINES; CARRIER PROTEINS; CELL LINE; HUMANS; HYPERURICEMIA; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTESTINES; KIDNEY; MALE; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; ORGANIC ANION TRANSPORTERS; OXONIC ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; URIC ACID;

EID: 84919326990     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.11.035     Document Type: Article

References (36)

1. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
2. H.J. Anders, B. Banas, and D. Schlondorff Signaling danger: toll-like receptors and their potential roles in kidney disease J. Am. Soc. Nephrol. 15 2004 854 867
3. P.J. Bakker, L.M. Butter, L. Kors, G.J. Teske, J. Aten, F.S. Sutterwala, S. Florquin, and J.C. Leemans Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation Kidney Int. 85 2013 1112 1122
4. L.Y. Chen, Z. Lan, Q.X. Lin, X. Mi, Y.Y. He, L.H. Wei, Y.Y. Lin, Y. Zhang, and X.K. Deng Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice Food Chem. Toxicol. 52 2013 28 35
5. Z.Y. Chen, Y. Liu, B.Y. Sun, H. Li, J.Q. Dong, L.J. Zhang, L.M. Wang, P. Wang, Y. Zhao, and C. Chen Polyhydroxylated metallofullerenols stimulate IL-1beta secretion of macrophage through TLRs/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation Small 10 2014 2362 2372
6. A. Enomoto, H. Kimura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S.H. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi, H. Matsuo, Y. Kikuchi, T. Oda, K. Ichida, T. Hosoya, K. Shimokata, T. Niwa, Y Kanai, and H. Endou Molecular identification of a renal urate anion exchanger that regulates blood urate levels Nature 417 2002 443 447
7. A. Enomoto, and T. Niwa Roles of organic anion transporters in the progression of chronic renal failure Ther. Apher. Dial. 11 2007 27 31
8. C.Y. Fan, M.X. Wang, C.X. Ge, X. Wang, J.M. Li, and L.D. Kong Betaine supplementation protects against high-fructose-induced renal injury in rats J. Nutr. Biochem. 25 2014 353 362
9. Z.X. Guan, J. Wu, Z.L. Yu, Q.S. Liu, S.B. Zhang, J.J. Wang, and J. Li Effects of lotus leaf capsule on human's blood lipids disorder Chin. J. Cardiovasc. Rehabil. Med. 12 2003 294 297
10. Z.X. Guan, J. Wu, Z.L. Yu, Q.S. Liu, S.B. Zhang, J.J. Wang, and J. Li Effects on water extract of lotus leaf to improve in human's blood lipids disorder J. Chenzhou Med. Coll. 5 2003 3 6
11. F. Guo, X. Yang, X. Li, R. Feng, C. Guan, Y. Wang, Y. Li, and C. Sun Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters PLoS One 8 2013 e63770
12. H.J. Han, M.J. Lim, Y.J. Lee, J.H. Lee, I.S. Yang, and M. Tau Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-κB Am. J. Physiol. Renal Physiol. 292 2007 373 381
13. M.A. Hediger, R.J. Johnson, H. Miyazaki, and H. Endou Molecular physiology of urate transport Physiology 20 2005 125 133
14. S. Heemskerk, A.C. Wouterse, F.G. Russel, and R. Masereeuw Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia Eur. J. Pharmacol. 584 2008 390 397
15. L.W. Hu, W. Xu, X. Zhang, J. Su, X.R. Liu, H.Y. Li, and W.D. Zhang In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine J. Pharm. Pharmacol. 62 2010 658 662
16. Q.H. Hu, C. Wang, J.M. Li, D.M. Zhang, and L.D. Kong Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement Am. J. Physiol. Renal Physiol. 297 2009 1080 1091
17. Q.H. Hu, X. Zhang, Y. Pan, Y.C. Li, and L.D. Kong Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats Biochem. Pharmacol. 84 2012 113 125
18. T. Jin, T.T. Wang, W. Yu, Q. Qiao, and G.R. Wang Effect of folium nelumbinis reducing blood fat decoction on uric acid and insulin resistance in patients with metabolic syndrome disease with hyperuricemia Chin. J. Integr. Tradt. West. Med. Intensive Crit. Care 18 2011 89 91
19. R.J. Johnson, T. Nakagawa, L.G. Sanchez-Lozada, M. Shafiu, S. Sundaram, M. Le, T. Ishimoto, Y.Y. Sautin, and M.A. Lanaspa Sugar, uric acid, and the etiology of diabetes and obesity Diabetes 62 2013 3307 3315
20. M.C. Lin, S.H. Kao, P.J. Chung, K.C. Chan, M.Y. Yang, and C.J. Wang Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf J. Agric. Food Chem. 57 2009 5925 5932
21. Y.L. Liu, Y. Pan, X. Wang, C.Y. Fan, Q. Zhu, J.M. Li, S.J. Wang, and L.D. Kong Betaine reduces serum uric acid levels and improves kidney function in hyperuricemic mice Planta Med. 80 2014 39 47
22. A. Nakayama, H. Matsuo, T. Takada, K. Ichida, T. Nakamura, Y. Ikebuchi, K. Ito, T. Hosoya, Y. Kanai, H. Suzuki, and N. Shinomiya ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans Nucleosides Nucleotides Nucleic Acids 30 2011 1091 1097
23. K.H. Nguyen, T.N. Ta, T.H. Pham, Q.T. Nguyen, H.D. Pham, S. Mishra, and B.L. Nyomba Nuciferine stimulates insulin secretion from beta cells - an in vitro comparison with glibenclamide J. Ethnopharmacol. 142 2012 488 495
24. R.P. Obermayr, C. Temml, G. Gutjahr, M. Knechtelsdorfer, R. Oberbauer, and R. Klauser-Braun Elevated uric acid increases the risk for kidney disease J. Am. Soc. Nephrol. 19 2008 2407 2413
25. F. Preitner, O. Bonny, A. Laverriere, S. Rotman, D. Firsov, A. Da Costa, S. Metref, and B. Thorens Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy Proc. Natl. Acad. Sci. USA 106 2009 15501 15506
26. E.S. Ryu, M.J. Kim, H.S. Shin, Y.H. Jang, H.S. Choi, I. Jo, R.J. Johnson, and D.H. Kang Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease Am. J. Physiol. Renal Physiol. 304 2013 F471 F480
27. K. Schroder, and J. Tschopp The inflammasomes Cell 140 2010 821 832
28. S.K. Sinha, M. Shaheen, T.B. Rajavashisth, D.Y. Pan, K.C. Norris, and S.B. Nicholas Association of race/ethnicity, inflammation, and albuminuria in patients with diabetes and early chronic kidney disease Diabetes Care 37 2014 1060 1068
29. S. Sonne, P.S. Shekhawat, D. Matern, V. Ganapathy, and L. Ignatowicz Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response PLoS One 7 2012 e47729
30. V. Vitart, I. Rudan, C. Hayward, N.K. Gray, J. Floyd, C.N. Palmer, S.A. Knott, I. Kolcic, O. Polasek, J. Graessler, J.F. Wilson, A. Marinaki, P.L. Riches, and X.J. Shu SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout Nat. Genet. 40 2008 437 442
31. C. Wang, Y. Pan, Q.Y. Zhang, F.M. Wang, and L.D. Kong Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation PLoS One 7 2012 e38285
32. X. Wang, C.P. Wang, Q.H. Hu, Y.Z. Lv, X. Zhang, Z. Ouyang, and L.D. Kong The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice J. Ethnopharmacol. 128 2010 107 115
33. D.E. Weiner, H. Tighiouart, E.F. Elsayed, J.L. Griffith, D.N. Salem, and A.S. Levey Uric acid and incident kidney disease in the community J. Am. Soc. Nephrol. 19 2008 1204 1211
34. B.Y. Yang, Z.N. Mo, C. Wu, H.D. Yang, X.B. Yang, Y.F. He, Lixuan Gui, L.i. Zhou, and X.Z. Huan Guo A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population BMC Med. Genomics 7 2014 10
35. D.M. Zhang, Y.C. Li, D. Xu, X.Q. Ding, and L.D. Kong Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats Food Chem. 134 2012 2184 2193
36. Y. Zhou, L. Fang, L. Jiang, P. Wen, H.D. Cao, W.C. He, C.S. Dai, and J. Yang Uric acid induces renal inflammation via activating tubular NF-kappaB signaling pathway PLoS One 7 2012 e39738