Betaine reduces serum uric acid levels and improves kidney function in hyperuricemic mice

Planta Medica

Volumn 80, Issue 1, 2014, Pages 39-47

  Liu, Yang Liu ^a   Pan, Ying ^a   Wang, Xing ^a   Fan, Chen Yu ^a   Zhu, Qin ^a   Li, Jian Mei ^a   Wang, Shui Juan ^a   Kong, Ling Dong ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

betaine; hyperuricemic mice; renal function; renal organic ion transporters

Indexed keywords

BENZBROMARONE; BETA 2 MICROGLOBULIN; BETAINE; BREAST CANCER RESISTANCE PROTEIN; CARNITINE TRANSPORTER 1; CARNITINE TRANSPORTER 2; CREATININE; GLUCOSE TRANSPORTER 9; N ACETYL BETA GLUCOSAMINIDASE; NITROGEN; ORGANIC ANION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 1; OTERACIL POTASSIUM; UNCLASSIFIED DRUG; UREA; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA 2 MICROGLOBULIN URINE LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET SUPPLEMENTATION; HYPERURICEMIA; KIDNEY FUNCTION; MALE; MOUSE; NONHUMAN; UPREGULATION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL;

MUS;

ACETYLGLUCOSAMINIDASE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; BETAINE; BLOOD UREA NITROGEN; CARRIER PROTEINS; CREATININE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HYPERURICEMIA; KIDNEY; MALE; MEMBRANE PROTEINS; MICE; OCTAMER TRANSCRIPTION FACTOR-1; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; URIC ACID;

EID: 84892436830     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0033-1360127     Document Type: Article

References (45)

1. Becker M. A., Jolly M. Hyperuricemia and associated diseases. Rheum Dis Clin North Am: 2006; 32 275 293 (Pubitemid 43728824)
2. Anzai N., Miyazaki H., Noshiro R., Khamdang S., Chairoungdua A., Shin H. J., Enomoto A., Sakamoto S., Hirata T., Tomita K., Kanai Y., Endou H. The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J Biol Chem: 2004; 279 45942 45950 (Pubitemid 39491587)
3. Wakida N., Tuyen D. G., Adachi M., Miyoshi T., Nonoguchi H., Oka T., Ueda O., Tazawa M., Kurihara S., Yoneta Y., Shimada H., Oda T., Kikuchi Y., Matsuo H., Hosoyamada M., Endou H., Otagiri M., Tomita K., Kitamura K. Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia. J Clin Endocrinol Metab: 2005; 90 2169 2174 (Pubitemid 40586257)
4. Preitner F., Bonny O., Laverrière A., Rotman S., Firsov D., Da Costa A., Metref S., Thorens B. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci USA: 2009; 106 15501 15506
5. Vitart V., Rudan I., Hayward C., Gray N. K., Floyd J., Palmer C. NA, Knott S. A., Kolcic I., Polasek O., Graessler J. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet: 2008; 40 437 442 (Pubitemid 351450879)
6. Hediger M. A., Johnson R. J., Miyazaki H., Endou H. Molecular physiology of urate transport. Physiology: 2005; 20 125 133 (Pubitemid 40627553)
7. Eraly S. A., Vallon V., Rieg T., Gangoiti J. A., Wikoff W. R., Siuzdak G., Barshop B. A., Nigam S. K. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genom: 2008; 33 180 192 (Pubitemid 351629526)
8. Woodward O. M., Kottgen A., Coresh J., Boerwinkle E., Guggino W. B., Kottgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci USA: 2009; 106 10338 10342
9. Iseki K., Oshiro S., Tozawa M., Iseki C., Ikemiya Y., Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects. Hypertens Res: 2001; 24 691 697 (Pubitemid 33133783)
10. Sun H., Frassetto L., Benet L. Z. Effects of renal failure on drug transport and metabolism. Pharmacol Ther: 2006; 109 1 11 (Pubitemid 41740811)
11. Deguchi T., Kusuhara H., Takadate A., Endou H., Otagiri M., Sugiyama Y. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int: 2004; 65 162 174 (Pubitemid 38037501)
12. Peltekova V. D., Wintle R. F., Rubin L. A., Amos C. I., Huang Q., Gu X., Newman B., Van Oene M., Cescon D., Greenberg G., Griffiths A. M., St George-Hyslop P. H., Siminovitch K. A. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet: 2004; 36 471 475 (Pubitemid 38620030)
13. Huls M., van den Heuvel J. J., Dijkman H. B., Russel F. G., Masereeuw R. ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. Kidney Int: 2006; 69 2186 2193 (Pubitemid 43882105)
14. Craig S. A. Betaine in human nutrition. Am J Clin Nutr: 2004; 80 539 549 (Pubitemid 41115516)
15. Olthof M. R., Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab: 2005; 6 15 22 (Pubitemid 40277877)
16. Abdelmalek M. F., Sanderson S. O., Angulo P., Soldevila-Pico C., Liu C., Peter J., Keach J., Cave M., Chen T., McClain C. J., Lindor K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepatology: 2009; 50 1818 1826
17. Olthof M. R., van Vliet T., Verhoef P., Zock P. L., Katan M. B. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. Plos Med: 2005; 2 e135
18. Zhan X. A., Li J. X., Xu Z. R., Zhao R. Q. Effects of methionine and betaine supplementation on growth performance, carcase composition and metabolism of lipids in male broilers. Br Poult Sci: 2006; 47 576 580 (Pubitemid 44623223)
19. Ozturk F., Ucar M., Ozturk I. C., Vardi N., Batcioglu K. Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology: 2003; 62 353 356 (Pubitemid 36952105)
20. Chen G. L., Wei W., Xu S. Y. Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia. Am J Chin Med: 2006; 34 77 85 (Pubitemid 43231403)
21. Wang C. P., Wang Y., Wang X., Zhang X., Ye J. F., Hu L. S., Kong L. D. Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med: 2011; 77 786 794
22. Li J. M., Zhang X., Wang X., Xie Y. C., Kong L. D. Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice. Eur J Pharmacol: 2011; 666 196 204
23. Hu Q. H., Zhang X., Wang X., Jiao R. Q., Kong L. D. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Eur J Nutr: 2012; 51 593 606
24. Jung Y. S., Kim S. J., Kwon D. Y., Ahn C. W., Kim Y. S., Choi D. W., Kim Y. C. Alleviation of alcoholic liver injury by betaine involves an enhancement of antioxidant defense via regulation of sulfur amino acid metabolism. Food Chem Toxicol: 2013; 62?C 292 298
25. Ozer J. S., Dieterle F., Troth S., Perentes E., Cordier A., Verdes P., Staedtler F., Mahl A., Grenet O., Roth D. R., Wahl D., Legay F., Holder D., Erdos Z., Vlasakova K., Jin H., Yu Y., Muniappa N., Forest T., Clouse H. K., Reynolds S., Bailey W. J., Thudium D. T., Topper M. J., Skopek T. R., Sina J. F., Glaab W. E., Vonderscher J., Maurer G., Chibout S. D., Sistare F. D., Gerhold D. L. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat Biotechnol: 2010; 28 486 494
26. Haring N., Mahr H. S., Mundle M., Strohal R., Lhotta K. Early detection of renal damage caused by fumaric acid ester therapy by determination of urinary β 2-microglobulin. Br J Dermatol: 2011; 164 648 651
27. Deuring J. J., de Haar C., Koelewijn C. L., Kuipers E. J., Peppelenbosch M. P., van der Woude C. J. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Biochem J: 2012; 441 87 93
28. Heemskerk S., Wouterse A. C., Russel F. G., Masereeuw R. Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Eur J Pharmacol: 2008; 584 390 397
29. Mukherjee M., Latif M. L., Pritchard D. I., Bosquillon C. In-cell Western detection of organic cation transporters in bronchial epithelial cell layers cultured at an air-liquid interface on Transwell inserts. J Pharmacol Toxicol Methods: 2013; 68 184 189
30. Sjakste N., Baumane L., Boucher J. L., Dzintare M., Meirena D., Sjakste J., Lauberte L., Kalvinsh I. Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats. Basic Clin Pharmacol Toxicol: 2004; 94 46 50 (Pubitemid 38428819)
31. Nakanishi T., Burg M. B. Osmoregulatory fluxes of myo-inositol and betaine in renal cells. Am J Physiol: 1989; 257 C964 970
32. Moeckel G. W., Lai L. W., Guder W. G., Kwon H. M., Lien Y. H. Kinetics and osmoregulation of Na(+)-and Cl(-)-dependent betaine transporter in rat renal medulla. Am J Physiol: 1997; 272 F100 F106 (Pubitemid 27382285)
33. Iharada M., Miyaji T., Fujimoto T., Hiasa M., Anzai N., Omote H., Moriyama Y. Type 1 sodium-dependent phosphate transporter (SLC17A1 protein) is a Cl(-)-dependent urate exporter. J Biol Chem: 2010; 285 26107 26113
34. Wagner C. A., Lukewille U., Kaltenbach S., Moschen I., Broer A., Risler T., Broer S., Lang F. Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol: 2000; 279 F584 F591
35. Nakanishi T., Hatanaka T., Huang W., Prasad P. D., Leibach F. H., Ganapathy M. E., Ganapathy V. Na+-and Cl - coupled active transport of carnitine by the amino acid transporter ATB (0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. J Physiol: 2001; 532 297 304 (Pubitemid 32390389)
36. Choi H. K., Liu S., Curhan G. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the third national health and nutrition examination survey. Arthritis Rheum: 2005; 52 283 289 (Pubitemid 40129260)
37. Choi J. W., Ford E. S., Gao X., Choi H. K. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum: 2008; 59 109 116 (Pubitemid 351171885)
38. Lever M., George P. M., Slow S., Elmslie J. L., Scott R. S., Richards A. M., Fink J. N., Chambers S. T. Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine. Cardiovasc Drugs Ther: 2009; 23 395 401
39. Storch K. J., Wagner D. A., Young V. R. Methionine kinetics in adult men: effects of dietary betaine on L-[2H3-methyl-1-13C] methionine. Am J Clin Nutr: 1991; 54 386 394 (Pubitemid 21898947)
40. McGregor D. O., Dellow W. J., Robson R. A., Lever M., George P. M., Chambers S. T. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int: 2002; 61 1040 1046 (Pubitemid 34175473)
41. Dellow W. J., Chambers S. T., Lever M., Lunt H., Robson R. A. Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Res Clin Pract: 1999; 43 91 99 (Pubitemid 29155653)
42. Schwab U., Alfthan G., Aro A., Uusitupa M. Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects. Eur J Clin Nutr: 2011; 65 70 76
43. Abdelmalek M. F., Angulo P., Jorgensen R. A., Sylvestre P. B., Lindor K. D. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol: 2001; 96 2711 2717
44. Slow S., Donaggio M., Cressey P. J., Lever M., George P. M., Chambers S. T. The betaine content of New Zealand foods and estimated intake in the New Zealand diet. J Food Compost Anal: 2005; 18 473 485 (Pubitemid 40277328)
45. Perez-Ruiz F., Calabozo M., Erauskin G. G., Ruibal A., Herrero-Beites A. M. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum: 2002; 47 610 613 (Pubitemid 35461313)