A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery

Bone

Volumn 72, Issue , 2015, Pages 128-136

  Inzana, Jason A ^a,b   Schwarz, Edward M ^a,b   Kates, Stephen L ^a   Awad, Hani A ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b University of Rochester   (United States)

Author keywords

Antibiotics; Bone infection; Mouse; Osteomyelitis; PMMA; Revision

Indexed keywords

POLY(METHYL METHACRYLATE); VANCOMYCIN; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BONE INFECTION; BONE PLATE; BONE RADIOGRAPHY; BONE SCREW; COLONY FORMING UNIT; CONTROLLED STUDY; DEBRIDEMENT; FEMALE; FRACTURE FIXATION; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOTOMY; STAPHYLOCOCCUS INFECTION; SURGICAL APPROACH; VOLUMETRY; ANIMAL; BAGG ALBINO MOUSE; BIOFILM; BONE; BONE DISEASES; CHEMISTRY; DISEASE MODEL; FRACTURE HEALING; MICROBIOLOGY; OSTEOMYELITIS; PATHOLOGY; REOPERATION; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOFILMS; BONE AND BONES; BONE DISEASES; DEBRIDEMENT; DISEASE MODELS, ANIMAL; FEMALE; FRACTURE HEALING; MICE; MICE, INBRED BALB C; OSTEOLYSIS; OSTEOMYELITIS; POLYMETHYL METHACRYLATE; REOPERATION; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME; VANCOMYCIN; X-RAY MICROTOMOGRAPHY;

EID: 84918839186     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.11.019     Document Type: Article

References (39)

1. Darouiche R.O. Treatment of infections associated with surgical implants. N Engl J Med 2004, 350(14):1422-1429. 10.1056/NEJMra035415.
2. Patil S., Montgomery R. Management of complex tibial and femoral nonunion using the Ilizarov technique, and its cost implications. J Bone Joint Surg Br 2006, 88(7):928-932. 10.1302/0301-620X.88B7.17639.
3. Zalavras C.G., et al. Management of open fractures. Infect Dis Clin North Am 2005, 19(4):915-929. 10.1016/j.idc.2005.08.001.
4. Webb J.C., Spencer R.F. The role of polymethylmethacrylate bone cement in modern orthopaedic surgery. J Bone Joint Surg Br 2007, 89(7):851-857. 10.1302/0301-620X.89B7.19148.
5. Jaeblon T. Polymethylmethacrylate: properties and contemporary uses in orthopaedics. J Am Acad Orthop Surg 2010, 18(5):297-305.
6. Beeching N.J., et al. Comparative in-vitro activity of antibiotics incorporated in acrylic bone cement. J Antimicrob Chemother 1986, 17(2):173-184.
7. Li B., et al. Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model. J Control Release 2010, 145(3):221-230. 10.1016/j.jconrel.2010.04.002.
8. Brown K.V., et al. Earlier debridement and antibiotic administration decrease infection. J Surg Orthop Adv 2010, 19(1):18-22.
9. Matsuno H., et al. A new antibacterial carrier of hyaluronic acid gel. J Orthop Sci 2006, 11(5):497-504. 10.1007/s00776-006-1059-0.
10. Clasper J.C., et al. Spread of infection, in an animal model, after intramedullary nailing of an infected external fixator pin track. J Orthop Res 2001, 19(1):155-159. 10.1016/S0736-0266(00)00023-1.
11. Nair M.B., et al. Infection and tissue engineering in segmental bone defects-a mini review. Curr Opin Biotechnol 2011, 22(5):721-725. 10.1016/j.copbio.2011.02.005.
12. Reizner W., et al. A systematic review of animal models for Staphylococcus aureus osteomyelitis. Eur Cell Mater 2014, 27:196-212.
13. Chen X., et al. Characterization of a chronic infection in an internally-stabilized segmental defect in the rat femur. J Orthop Res 2005, 23(4):816-823. 10.1016/j.orthres.2005.01.009.
14. Calhoun J.H., Manring M.M. Adult osteomyelitis. Infect Dis Clin North Am 2005, 19(4):765-786. 10.1016/j.idc.2005.07.009.
15. Matthys R., Perren S.M. Internal fixator for use in the mouse. Injury 2009, 40(Suppl. 4):S103-S109. 10.1016/j.injury.2009.10.044.
16. Arciola C.R., et al. Prevalence of cna, fnbA and fnbB adhesin genes among Staphylococcus aureus isolates from orthopedic infections associated to different types of implant. FEMS Microbiol Lett 2005, 246(1):81-86. 10.1016/j.femsle.2005.03.035.
17. Li D., et al. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J Orthop Res 2008, 26(1):96-105. 10.1002/jor.20452.
18. Green J.M., et al. Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria mode. Curr Rheumatol Rep 2013, 15(5):325. 10.1007/s11926-013-0325-3.
19. Li D., et al. Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Ann N Y Acad Sci 2010, 1192:4-94. 10.1111/j.1749-6632.2009.05210.x.
20. Niska J.A., et al. Vancomycin-rifampin combination therapy has enhanced efficacy against an experimental Staphylococcus aureus prosthetic joint infection. Antimicrob Agents Chemother 2013, 57(10):5080-5086. 10.1128/AAC.00702-13.
21. Healy D.P., et al. Comparison of steady-state pharmacokinetics of two dosage regimens of vancomycin in normal volunteers. Antimicrob Agents Chemother 1987, 31(3):393-397.
22. Albrecht L.M., et al. Vancomycin protein binding in patients with infections caused by Staphylococcus aureus. DICP 1991, 25(7-8):713-715.
23. Crandon J.L., Kuti J.L., Nicolau D.P. Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. Antimicrob Agents Chemother 2010, 54(12):5115-5119. 10.1128/AAC.00062-10.
24. Pribaz J.R., et al. Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study. J Orthop Res 2012, 30(3):335-340. 10.1002/jor.21519.
25. Shandley S., et al. Hyperbaric oxygen therapy in a mouse model of implant-associated osteomyelitis. J Orthop Res 2012, 30(2):203-208. 10.1002/jor.21522.
26. Varrone J.J., et al. Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters. J Orthop Res 2014, 32(10):1389-1396. 10.1002/jor.22672.
27. Trampuz A., Widmer A.F. Infections associated with orthopedic implants. Curr Opin Infect Dis 2006, 19(4):349-356. 10.1097/01.qco.0000235161.85925.e8.
28. Bosse M.J., Gruber H.E., Ramp W.K. Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case report. J Bone Joint Surg Am 2005, 87(6):1343-1347. 10.2106/JBJS.D.02649.
29. Rani S.A., et al. Spatial patterns of DNA replication, protein synthesis, and oxygen concentration within bacterial biofilms reveal diverse physiological states. J Bacteriol 2007, 189(11):4223-4233. 10.1128/JB.00107-07.
30. Gogia J.S., et al. Local antibiotic therapy in osteomyelitis. Semin Plast Surg 2009, 23(2):100-107. 10.1055/s-0029-1214162.
31. Ferraris S., et al. In vitro comparison between commercially and manually mixed antibiotic-loaded bone cements. J Appl Biomater Biomech 2010, 8(3):166-174.
32. Mariconda M., et al. Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty. BMC Musculoskelet Disord 2013, 14:193. 10.1186/1471-2474-14-193.
33. Schmolders J., et al. Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee. BMC Infect Dis 2014, 14:144. 10.1186/1471-2334-14-144.
34. Wang G., et al. Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period. J Clin Microbiol 2006, 44(11):3883-3886. 10.1128/JCM.01388-06.
35. Darouiche R.O., et al. Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria. J Infect Dis 1994, 170(3):720-723.
36. Jefferson K.K., Goldmann D.A., Pier G.B. Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms. Antimicrob Agents Chemother 2005, 49(6):2467-2473. 10.1128/AAC.49.6.2467-2473.2005.
37. Zimmerli W., Trampuz A., Ochsner P.E. Prosthetic-joint infections. N Engl J Med 2004, 351(16):1645-1654. 10.1056/NEJMra040181.
38. Tang H.J., et al. In vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2013, 57(11):5717-5720. 10.1128/AAC.01236-13.
39. Mihailescu R., et al. High activity of fosfomycin and rifampin against methicillin-resistant Staphylococcus aureus biofilm in vitro and in an experimental foreign-body infection model. Antimicrob Agents Chemother 2014, 58(5):2547-2553. 10.1128/AAC.02420-12.