Characterization of a chronic infection in an internally-stabilized segmental defect in the rat femur

Journal of Orthopaedic Research

Volumn 23, Issue 4, 2005, Pages 816-823

  Chen, Xinqian ^a   Tsukayama, Dean T ^b   Kidder, Louis S ^a   Bourgeault, Craig A ^a   Schmidt, Andrew H ^b   Lew, William D ^a  

^a MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

Antibiotic; Bone lysis; Chronic osteomyelitis; Quantitative bacteriology; Segmental bone defect

Indexed keywords

CEFTRIAXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIUM CONTAMINATION; BACTERIUM DETECTION; BONE DEFECT; BONE PLATE; CHRONIC OSTEOMYELITIS; COLONY FORMING UNIT; CONTROLLED STUDY; DEBRIDEMENT; FEMUR; FRACTURE FIXATION; KIRSCHNER WIRE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; RAT; REBOUND; RIGIDITY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STATISTICAL SIGNIFICANCE; TORSION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CHRONIC DISEASE; COMBINED MODALITY THERAPY; DEBRIDEMENT; DISEASE MODELS, ANIMAL; FEMUR; FRACTURE FIXATION, INTERNAL; OSTEOLYSIS; OSTEOMYELITIS; RATS; RATS, SPRAGUE-DAWLEY; STAPHYLOCOCCAL INFECTIONS; TORSION;

EID: 21844443332     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2005.01.009     Document Type: Article

References (35)

1. K.M. Alkharfy J.A. Kellum G.R. Matzke Unintended immunomodulation: Part II - Effects of pharmacological agents on cytokine activity Shock 13 2000 346-360
2. R.A. Bowden G.C. Racaro P.C. Baldi Effect of early antibiotic treatment on the antibody response to cytoplasmic proteins of Brucella melitensis in mice Clin Diagn Lab Immunol 6 1999 440-443
3. X. Chen L.S. Kidder W.D. Lew Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur J Orthop Res 20 2002 142-150
4. G.D. Christensen L.M. Baddour B.M. Madison Colonial morphology of staphylococci on Memphis agar: Phase variation of slime production, resistance to beta-lactam antibiotics, and virulence J Infect Dis 161 1990 1153-1169
5. J.W. Costerton P.S. Stewart E.P. Greenberg Bacterial biofilms: A common cause of persistent infections Science 284 1999 1318-1322
6. A.-C. Cremieux C. Carbon Experimental models of bone and prosthetic joint infections Clin Infect Dis 25 1997 1295-1302
7. D.M. Cullinane A. Fredrick S.R. Eisenberg Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect J Orthop Res 20 2002 579-586
8. R.O. Darouiche G.C. Landon J.M. Patti Role of Staphylococcus aureus surface adhesions in orthopaedic device infections: Are results model-dependent J Med Microbiol 46 1997 75-79
9. M.J. Federle B.L. Bassler Interspecies communication in bacteria J Clin Invest 112 2003 1291-1299
10. C.G. Gemmell Antibiotics and neutrophil function: Potential immunomodulating activities J Antimicrob Chemother 31 suppl 1993 23-33
11. A.G. Gristina G. Giridhar B.L. Gabriel Cell biology and molecular mechanisms in artificial device infections Int J Artificial Organs 16 1993 755-764
12. I. Keren N. Kaldalu A. Spoering Persister cells and tolerance to antimicrobials FEMS Microbiol Lett 230 2004 13-18
13. P. Klein H. Schell F. Streitparth The initial phase of fracture healing is specifically sensitive to mechanical conditions J Orthop Res 21 2003 662-669
14. M.T. Labro Interference of antibacterial agents with phagocyte functions: Immunomodulation or "immuno-fairy tales"? Clin Microbiol Rev 13 2000 615-650
15. J.M. Lane A.W. Yasko E. Tomin Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair Clin Orthop 361 1999 216-227
16. S.C. Lee M. Shea M.A. Battle Healing of large segmental defects in rat femurs is aided by rhBMP-2 in PLGA matrix J Biomed Mater Res 28 1994 1149-1156
17. J.R. Lieberman A. Daluiski S. Stevenson The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats J Bone Joint Surg 81A 1999 905-917
18. J.T. Mader Animal models of osteomyelitis Am J Med 78 suppl 1985 213-217
19. M. Monzon F. Garcia-Alvarez A. Lacleriga A simple infection model using pre-colonized implants to reproduce rat chronic Staphylococcus aureus osteomyelitis and study antibiotic treatment J Orthop Res 19 2001 820-826
20. D.E. Neal Jr M.B. Kaack G. Baskin J.A. Roberts Attenuation of antibody response to acute pyelonephritis by treatment with antibiotics Antimicrob Agents Chemother 35 1991 2340-2344
21. C.W. Norden Lessons learned from animal models of osteomyelitis Rev Infect Dis 10 1988 103-110
22. K. Ohura C. Hamanishi S. Tanaka N. Matsuda Healing of segmental bone defects in rats induced by a beta-TCP-MCPM cement combined with rhBMP-2 J Biomed Mater Res 44 1999 168-175
23. W. Petty S. Spanier J.J. Shuster C. Silverthorne The influence of skeletal implants on incidence of infection: Experiments in a canine model J Bone Joint Surg 67A 1985 1236-1244
24. J.P. Rissing Animal models of osteomyelitis: Knowledge, hypothesis, and speculation Infect Dis Clin N Am 4 1990 377-390
25. J.P. Rissing T.B. Buxton R.S. Weinstein R.K. Shockley Model of experimental chronic osteomyelitis in rats Infect Immun 47 1985 581-586
26. A.H. Schmidt M.F. Swiontkowski Pathophysiology of infections after internal fixation of fractures J Am Acad Orthop Surg 8 2000 285-291
27. S. Stevenson N. Cunningham J. Toth The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmental defects in rats J Bone Joint Surg 76A 1994 1676-1687
28. S. Stevenson X.Q. Li D.T. Davy Critical biological determinants of incorporation of non-vascularized cortical bone grafts: Quantification of a complex process and structure J Bone Joint Surg 79A 1997 1-16
29. A.D. Tice P.A. Hoaglund D.A. Shoultz Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy Am J Med 114 2003 723-728
30. J.Y. Wang D.T. Tsukayama B.H. Wicklund R.B. Gustilo Inhibition of T and B cell proliferation by titanium, cobalt, and chromium: Role of IL-2 and IL-6 J Biomed Mater Res 32 1996 655-661
31. J.Y. Wang B.H. Wicklund R.B. Gustilo D.T. Tsukayama Titanium, chromium and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro Biomaterials 17 1996 2233-2240
32. D. Wolff V.M. Goldberg S. Stevenson Histomorphometric analysis of the repair of a segmental diaphyseal defect with ceramic and titanium fibermetal implants: Effects of bone marrow J Orthop Res 12 1994 439-446
33. P.C.Y. Woo H.-W. Tsoi L.-P. Wong Antibiotics modulate vaccine-induced humoral immune response Clin Diagn Lab Immunol 6 1999 832-837
34. P. Worlock R. Slack L. Harvey R. Mawhinney The prevention of infection in open fractures: An experimental study of the effect of fracture stability Injury 25 1994 31-38
35. A.W. Yasko J.M. Lane E.J. Fellinger The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2) J Bone Joint Surg 74A 1992 659-670