Overcoming drug crystallization in electrospun fibers - Elucidating key parameters and developing strategies for drug delivery

International Journal of Pharmaceutics

Volumn 478, Issue 1, 2015, Pages 390-397

  Seif, Salem ^a,b   Franzen, Lutz ^a   Windbergs, Maike ^a,b,c  

^a SAARLAND UNIVERSITY   (Germany)

^b PharmBioTec GmbH   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Controlled drug release; Drug crystallization; Electrospinning; Nanofibers; Poly(vinyl alcohol); Polycaprolactone

Indexed keywords

CAFFEINE; POLYCAPROLACTONE; POLYMER; POLYVINYL ALCOHOL; SOLVENT; NANOFIBER; POLYESTER;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG STORAGE; ELECTROSPINNING; ELECTROSPUN FIBER; ENCAPSULATION; EVAPORATION; POLYMERIZATION; SCANNING ELECTRON MICROSCOPY; WOUND DRESSING; CHEMISTRY; DRUG FORMULATION; DRUG RELEASE;

CAFFEINE; CRYSTALLIZATION; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; NANOFIBERS; POLYESTERS; POLYVINYL ALCOHOL;

EID: 84918816981     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.11.045     Document Type: Article

References (36)

1. N. Choktaweesap, K. Arayanarakul, D. Aht-Ong, C. Meechaisue, and P. Supaphol Electrospun gelatin fibers: effect of solvent system on morphology and fiber diameters Polym. J. 39 2007 622 631
2. T.K. Dash, and V.B. Konkimalla Poly-ε-caprolactone based formulations for drug delivery and tissue engineering: a review J. Control. Release 158 2012 15 33
3. V. Garsuch, and J. Breitkreutz Novel analytical methods for the characterization of oral wafers Eur. J. Pharm. Biopharm. 73 2009 195 201
4. A. Greiner, and J.H. Wendorff Electrospinning: a fascinating method for the preparation of ultrathin fibers Angew. Chem. Int. Ed. Engl. 46 2007 5670 5703
5. C.M. Hsu, and S. Shivkumar N,N-dimethylformamide additions to the solution for the electrospinning of poly(epsilon-caprolactone) nanofibers Macromol. Mater. Eng. 289 2004 334 340
6. F. Ignatious, L. Sun, C.P. Lee, and J. Baldoni Electrospun nanofibers in oral drug delivery Pharm. Res. 27 2010 576 588
7. P. Jain, and A.K. Banga Induction and inhibition of crystallization in drug-in-adhesive-type transdermal patches Pharm. Res. 30 2013 562 571
8. T. Jarusuwannapoom, W. Hongroijanawiwat, S. Jitjaicham, L. Wannatong, M. Nithitanakul, C. Pattamaprom, P. Koombhongse, R. Rangkupan, and P. Supaphol Effect of solvents on electro-spinnability of polystyrene solutions and morphological appearance of resulting electrospun polystyrene fibers Eur. Polym. J. 41 2005 409 421
9. U.S. Kestur, and L.S. Taylor Role of polymer chemistry in influencing crystal growth rates from amorphous felodipine Cryst. Eng. Commun. 12 2010 2390 2397
10. T.G. Kim, D.S. Lee, and T.G. Park Controlled protein release from electrospun biodegradable fiber mesh composed of poly(epsilon-caprolactone) and poly(ethylene oxide) Int. J. Pharm. 338 2007 276 283
11. P.N. Kotiyanand, and P.R. Vavia Eudragits: role as crystallization inhibitors in drug-in-adhesive transdermal systems of estradiol Eur. J. Pharm. Biopharm. 52 2001 173 180
12. K.H. Lee, H.Y. Kim, M.S. Khil, Y.M. Ra, and D.R. Lee Characterization of nano-structured poly(epsilon-caprolactone) nonwoven mats via electrospinning Polymer 44 2003 1287 1294
13. D. Li, and Y.N. Xia Electrospinning of nanofibers: reinventing the wheel? Adv. Mater. 16 2004 1151 1170
14. H. Liu, K.K. Leonas, and Y.P. Zhao Antimicrobial properties and release profile of ampicillin from electrospun poly(epsilon-caprolactone) nanofiber yarns J. Eng. Fiber Fabr. 5 2010 10 19
15. X. Luo, C. Xie, H. Wang, C. Liu, S. Yan, and X. Li Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation Int. J. Pharm. 425 2012 19 28
16. A.J. Meinel, O. Germershaus, T. Luhmann, H.P. Merkle, and L. Meinel Electrospun matrices for localized drug delivery: current technologies and selected biomedical applications Eur. J. Pharm. Biopharm. 81 2012 1 13
17. Z.K. Nagy, K. Nyul, I. Wagner, K. Molnar, and G. Marosi Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl Express Polym. Lett. 4 2010 763 772
18. V.A. Perumal, T. Govender, D. Lutchman, and I. Mackraj Investigating a new approach to film casting for enhanced drug content uniformity in polymeric films Drug Dev. Ind. Pharm. 34 2008 1036 1047
19. S.S. Said, O.M. El-Halfawy, H.M. El-Gowelli, A.K. Aloufy, N.A. Boraei, and L.K. El-Khordagui Bioburden-responsive antimicrobial PLGA ultrafine fibers for wound healing Eur. J. Pharm. Biopharm. 80 2012 85 94
20. R. Schmid Re-interpretation of the solvent dielectric constant in coordination chemical terms J. Solution Chem. 12 1983 135 152
21. B.Y. Shekunov, and P. York Crystallization processes in pharmaceutical technology and drug delivery design J. Cryst. Growth 211 2000 122 136
22. T.J. Sill, and H.A. von Recum Electrospinning: applications in drug delivery and tissue engineering Biomaterials 29 2008 1989 2006
23. W.K. Son, J.H. Youk, T.S. Lee, and W.H. Park The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers Polymer 45 2004 2959 2966
24. J. Swiergiel, and J. Jadzyn Conductivity dynamics and static dielectric permittivity of highly conducting molecular liquids studied with impedance spectroscopy. Formamides J. Phys. Chem. B 113 2009 14225 14228
25. P. Taepaiboon, U. Rungsardthong, and P. Supaphol Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs Nanotechnology 17 2006 2317 2329
26. W.E. Teo, R. Inai, and S. Ramakrishna Technological advances in electrospinning of nanofibers Sci. Technol. Adv. Mater. 12 2011
27. G. Verreck, I. Chun, J. Peeters, J. Rosenblatt, and M.E. Brewster Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning Pharm. Res. 20 2003 810 817
28. G. Verreck, I. Chun, J. Rosenblatt, J. Peeters, A. Van Dijck, J. Mensch, M. Noppe, and M.E. Brewster Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer J. Control. Release 92 2003 349 360
29. P. Vrbata, P. Berka, D. Stranska, P. Dolezal, M. Musilova, and L. Cizinska Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen Int. J. Pharm. 457 2013 168 176
30. M.A. Woodruffand, and D.W. Hutmacher The return of a forgotten polymer - polycaprolactone in the 21st century Prog. Polym. Sci. 35 2010 1217 1256
31. R.K. Yang, R.C. Fuisz, G.L. Myers, J.M. Fuisz, Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom, United States Patent US 20090181069 A1 (2009).
32. M. Zamani, M.P. Prabhakaran, and S. Ramakrishna Advances in drug delivery via electrospun and electrosprayed nanomaterials Int. J. Nanomed. 8 2013 2997 3017
33. J. Zeng, L. Yang, Q. Liang, X. Zhang, H. Guan, X. Xu, X. Chen, and X. Jing Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation J. Control. Release 105 2005 43 51
34. S. Zhao, X. Wu, L. Wang, and Y. Huang Electrospinning of ethyl-cyanoethyl cellulose/tetrahydrofuran solutions J. Appl. Polym. Sci. 91 2004 242 246
35. X.H. Zong, K. Kim, D.F. Fang, S.F. Ran, B.S. Hsiao, and B. Chu Structure and process relationship of electrospun bioabsorbable nanofiber membranes Polymer 43 2002 4403 4412
36. X. Zong, K. Kim, D. Fang, S. Ran, B.S. Hsiao, and B. Chu Structure and process relationship of electrospun bioabsorbable nanofiber membranes Polymer 43 2002 4403 4412