메뉴 건너뛰기




Volumn 136, Issue 4, 2015, Pages 904-914

Folate intake and the risk of oral cavity and pharyngeal cancer: A pooled analysis within the International Head and Neck Cancer Epidemiology Consortium

(24)  Galeone, Carlotta a   Edefonti, Valeria b   Parpinel, Maria c   Leoncini, Emanuele d   Matsuo, Keitaro e   Talamini, Renato f   Olshan, Andrew F g   Zevallos, Jose P h   Winn, Deborah M i   Jayaprakash, Vijayvel j   Moysich, Kirsten j   Zhang, Zuo Feng k   Morgenstern, Hal l   Levi, Fabio m   Bosetti, Cristina a   Kelsey, Karl n   McClean, Michael o   Schantz, Stimson p   Yu, Guo Pei q   Boffetta, Paolo r   more..


Author keywords

Diet; Epidemiology; Folate intake; Oral cancer; Risk factor

Indexed keywords

FOLIC ACID; ANTINEOPLASTIC AGENT;

EID: 84918812149     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29044     Document Type: Article
Times cited : (58)

References (55)
  • 1
    • 85083601719 scopus 로고    scopus 로고
    • Globocan 2012 v1.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. In: Ferlay J, Soerjomataram I, Ervik M, et al., eds. IARC Cancer Base No. 10. Lyon, France: International Agency for Research on Cancer, 2013.
    • Globocan 2012 v1.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. In: Ferlay J, Soerjomataram I, Ervik M, et al., eds. IARC Cancer Base No. 10. Lyon, France: International Agency for Research on Cancer, 2013.
  • 2
    • 85083608996 scopus 로고    scopus 로고
    • Mouth, pharynx, and larynx. In World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR). Food, nutrition, physical activity, and the prevention of cancer: A global perspectiveed Washington, DC: American Institute for Cancer Research 2007. 245-9
    • Mouth, pharynx, and larynx. In: World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR). Food, nutrition, physical activity, and the prevention of cancer: A global perspectiveed. Washington, DC: American Institute for Cancer Research, 2007.245-9
  • 4
    • 0028854816 scopus 로고
    • Diet and nutrition in the etiology of oral cancer
    • Winn DM. Diet and nutrition in the etiology of oral cancer. Am J Clin Nutr 1995;61:437S-45S
    • (1995) Am J Clin Nutr , vol.61 , pp. 437S-445S
    • Winn, D.M.1
  • 5
    • 82955163965 scopus 로고    scopus 로고
    • Diet and the risk of head and neck cancer: A pooled analysis in the INHANCE consortium
    • Chuang SC, Jenab M, Heck JE, et al. Diet and the risk of head and neck cancer: A pooled analysis in the INHANCE consortium. Cancer Causes Control 2012;23:69-88
    • (2012) Cancer Causes Control , vol.23 , pp. 69-88
    • Chuang, S.C.1    Jenab, M.2    Heck, J.E.3
  • 6
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
    • Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage. Proc Natl Acad Sci USA 1997;94:3290-5
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3290-3295
    • Blount, B.C.1    Mack, M.M.2    Wehr, C.M.3
  • 7
    • 79251566165 scopus 로고    scopus 로고
    • Dietary folate intake and the risk of 11 types of cancer: A case-control study in Uruguay
    • Aune D, Deneo-Pellegrini H, Ronco AL, et al. Dietary folate intake and the risk of 11 types of cancer: A case-control study in Uruguay. Ann Oncol 2011;22:444-51
    • (2011) Ann Oncol , vol.22 , pp. 444-451
    • Aune, D.1    Deneo-Pellegrini, H.2    Ronco, A.L.3
  • 8
    • 0032890354 scopus 로고    scopus 로고
    • Diet and risk of cancer of the upper aerodigestive tract-II
    • De Stefani E, Ronco A, Mendilaharsu M, et al. Diet and risk of cancer of the upper aerodigestive tract-II. Nutrients. Oral Oncol 1999;35:22-6
    • (1999) Nutrients. Oral Oncol , vol.35 , pp. 22-26
    • De Stefani, E.1    Ronco, A.2    Mendilaharsu, M.3
  • 10
    • 0344825219 scopus 로고    scopus 로고
    • Folate intake and risk of oral and pharyngeal cancer
    • Pelucchi C, Talamini R, Negri E, et al. Folate intake and risk of oral and pharyngeal cancer. Ann Oncol 2003;14:1677-81
    • (2003) Ann Oncol , vol.14 , pp. 1677-1681
    • Pelucchi, C.1    Talamini, R.2    Negri, E.3
  • 11
    • 0036212583 scopus 로고    scopus 로고
    • Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico
    • Weinstein SJ, Gridley G, Harty LC, et al. Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. J Nutr 2002;132:762-7
    • (2002) J Nutr , vol.132 , pp. 762-767
    • Weinstein, S.J.1    Gridley, G.2    Harty, L.C.3
  • 12
    • 0025672630 scopus 로고
    • Folate status assessment
    • Bailey LB. Folate status assessment. J Nutr 1990; 120:1508-11
    • (1990) J Nutr , vol.120 , pp. 1508-1511
    • Bailey, L.B.1
  • 13
    • 0023091198 scopus 로고
    • Effects of prolonged ethanol feeding on methionine metabolism in rat liver
    • Barak AJ, Beckenhauer HC, Tuma DJ, et al. Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 1987;65:230-3
    • (1987) Biochem Cell Biol , vol.65 , pp. 230-233
    • Barak, A.J.1    Beckenhauer, H.C.2    Tuma, D.J.3
  • 14
    • 23144461860 scopus 로고    scopus 로고
    • Effects of alcohol on folate metabolism: Implications for carcinogenesis
    • Mason JB, Choi SW. Effects of alcohol on folate metabolism: Implications for carcinogenesis. Alcohol 2005;35:235-41
    • (2005) Alcohol , vol.35 , pp. 235-241
    • Mason, J.B.1    Choi, S.W.2
  • 15
    • 0027055823 scopus 로고
    • Localized deficiencies of folic acid in aerodigestive tissues
    • discussion 95-6
    • Heimburger DC. Localized deficiencies of folic acid in aerodigestive tissues. Ann N Y Acad Sci 1992;669:87-95; discussion 95-6
    • (1992) Ann N y Acad Sci , vol.669 , pp. 87-95
    • Heimburger, D.C.1
  • 16
    • 0026698664 scopus 로고
    • Effect of smoking on folate levels in buccal mucosal cells
    • Piyathilake CJ, Hine RJ, Dasanayake AP, et al. Effect of smoking on folate levels in buccal mucosal cells. Int J Cancer 1992;52:566-9
    • (1992) Int J Cancer , vol.52 , pp. 566-569
    • Piyathilake, C.J.1    Hine, R.J.2    Dasanayake, A.P.3
  • 17
    • 84858293257 scopus 로고    scopus 로고
    • Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese
    • Matsuo K, Rossi M, Negri E, et al. Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. Eur J Cancer Prev 2012;21:193-8
    • (2012) Eur J Cancer Prev , vol.21 , pp. 193-198
    • Matsuo, K.1    Rossi, M.2    Negri, E.3
  • 18
    • 77958078030 scopus 로고    scopus 로고
    • Alcohol-folate interactions in the risk of oral cancer in women: A prospective cohort study
    • Shanmugham JR, Zavras AI, Rosner BA, et al. Alcohol-folate interactions in the risk of oral cancer in women: A prospective cohort study. Cancer Epidemiol Biomarkers Prev 2010;19:2516-24
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2516-2524
    • Shanmugham, J.R.1    Zavras, A.I.2    Rosner, B.A.3
  • 19
    • 68949216415 scopus 로고    scopus 로고
    • Enhancing epidemiologic research on head and neck cancer: INHANCE-The international head and neck cancer epidemiology consortium
    • Conway DI, Hashibe M, Boffetta P, et al. Enhancing epidemiologic research on head and neck cancer: INHANCE-The international head and neck cancer epidemiology consortium. Oral Oncol 2009;45:743-6
    • (2009) Oral Oncol , vol.45 , pp. 743-746
    • Conway, D.I.1    Hashibe, M.2    Boffetta, P.3
  • 20
    • 84896899629 scopus 로고    scopus 로고
    • Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium
    • Leoncini E, Ricciardi W, Cadoni G, et al. Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. Eur J Epidemiol 2014;29:35-48
    • (2014) Eur J Epidemiol , vol.29 , pp. 35-48
    • Leoncini, E.1    Ricciardi, W.2    Cadoni, G.3
  • 21
    • 34447266437 scopus 로고    scopus 로고
    • Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    • Hashibe M, Brennan P, Benhamou S, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst 2007;99:777-89
    • (2007) J Natl Cancer Inst , vol.99 , pp. 777-789
    • Hashibe, M.1    Brennan, P.2    Benhamou, S.3
  • 22
    • 84896899629 scopus 로고    scopus 로고
    • Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium
    • Leoncini E, Ricciardi W, Cadoni G, et al. Adult height and head and neck cancer: A pooled analysis within the INHANCE Consortium. Eur J Epidemiol 2014;29:35-48
    • (2014) Eur J Epidemiol , vol.29 , pp. 35-48
    • Leoncini, E.1    Ricciardi, W.2    Cadoni, G.3
  • 23
    • 2942729720 scopus 로고    scopus 로고
    • The update of the italian food composition database
    • Gnagnarella P, Parpinel M, Salvini S, et al. The update of the Italian Food Composition Database. J Food Compos Anal 2004;17:509-22
    • (2004) J Food Compos Anal , vol.17 , pp. 509-522
    • Gnagnarella, P.1    Parpinel, M.2    Salvini, S.3
  • 26
    • 85083605713 scopus 로고    scopus 로고
    • U.S. Department of Agriculture ARS.USDA Agriculture Handbooks No.8, 1-19ed. Composition of foods: Raw, processed, prepared. USDA National Nutrient Database for Standard Reference.
    • U.S. Department of Agriculture ARS. USDA. Agriculture Handbooks No.8, 1-19ed. Composition of foods: Raw, processed, prepared. USDA National Nutrient Database for Standard Reference. http://www.nal.usda.gov/ref/USDApubs/aghandbk.htm#sortnbr
  • 27
    • 85083605887 scopus 로고    scopus 로고
    • Resources Council Science Technology Agency Japan. Standard tables of food composition in Japan 5th revised edn. Tokyo: Ministry of Finance Printing Bureau 2000
    • Resources Council, Science and Technology Agency, Japan. Standard tables of food composition in Japan, 5th revised edn. Tokyo: Ministry of Finance Printing Bureau, 2000
  • 28
    • 0142181066 scopus 로고    scopus 로고
    • Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract
    • Bosetti C, Gallus S, Trichopoulou A, et al. Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 2003;12:1091-4
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 1091-1094
    • Bosetti, C.1    Gallus, S.2    Trichopoulou, A.3
  • 29
    • 0031822445 scopus 로고    scopus 로고
    • Food groups and risk of oral and pharyngeal cancer
    • Levi F, Pasche C, La Vecchia C, et al. Food groups and risk of oral and pharyngeal cancer. Int J Cancer 1998;77:705-9
    • (1998) Int J Cancer , vol.77 , pp. 705-709
    • Levi, F.1    Pasche, C.2    La Vecchia, C.3
  • 30
    • 84888866190 scopus 로고    scopus 로고
    • Foods, nutrients and the risk of oral and pharyngeal cancer
    • Bravi F, Bosetti C, Filomeno M, et al. Foods, nutrients and the risk of oral and pharyngeal cancer. Br J Cancer 2013;109:2904-10
    • (2013) Br J Cancer , vol.109 , pp. 2904-2910
    • Bravi, F.1    Bosetti, C.2    Filomeno, M.3
  • 31
    • 33751278942 scopus 로고    scopus 로고
    • Chemoprevention of head and neck cancer with aspirin: A case-control study
    • Jayaprakash V, Rigual NR, Moysich KB, et al. Chemoprevention of head and neck cancer with aspirin: A case-control study. Arch Otolaryngol Head Neck Surg 2006;132:1231-6
    • (2006) Arch Otolaryngol Head Neck Surg , vol.132 , pp. 1231-1236
    • Jayaprakash, V.1    Rigual, N.R.2    Moysich, K.B.3
  • 32
    • 0023918772 scopus 로고
    • Smoking and drinking in relation to oral and pharyngeal cancer
    • Blot WJ, McLaughlin JK, Winn DM, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988;48:3282-7
    • (1988) Cancer Res , vol.48 , pp. 3282-3287
    • Blot, W.J.1    McLaughlin, J.K.2    Winn, D.M.3
  • 33
    • 0030913602 scopus 로고    scopus 로고
    • Genetic susceptibility to head and neck cancer: Interaction between nutrition and mutagen sensitivity
    • Schantz SP, Zhang ZF, Spitz MS, et al. Genetic susceptibility to head and neck cancer: Interaction between nutrition and mutagen sensitivity. Laryngoscope 1997;107:765-81
    • (1997) Laryngoscope , vol.107 , pp. 765-781
    • Schantz, S.P.1    Zhang, Z.F.2    Spitz, M.S.3
  • 34
    • 13944277659 scopus 로고    scopus 로고
    • The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use
    • Peters ES, McClean MD, Liu M, et al. The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev 2005;14:476-82
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 476-482
    • Peters, E.S.1    McClean, M.D.2    Liu, M.3
  • 35
    • 30444442970 scopus 로고    scopus 로고
    • Polymorphism of Xeroderma pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus
    • Cui Y, Morgenstern H, Greenland S, et al. Polymorphism of Xeroderma pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus. Int J Cancer 2006;118:714-20
    • (2006) Int J Cancer , vol.118 , pp. 714-720
    • Cui, Y.1    Morgenstern, H.2    Greenland, S.3
  • 36
    • 77953291984 scopus 로고    scopus 로고
    • Oral health and risk for head and neck squamous cell carcinoma: The Carolina Head and Neck Cancer Study
    • Divaris K, Olshan AF, Smith J, et al. Oral health and risk for head and neck squamous cell carcinoma: The Carolina Head and Neck Cancer Study. Cancer Causes Control 2010;21:567-75
    • (2010) Cancer Causes Control , vol.21 , pp. 567-575
    • Divaris, K.1    Olshan, A.F.2    Smith, J.3
  • 37
    • 33745592498 scopus 로고    scopus 로고
    • Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
    • Suzuki T, Wakai K, Matsuo K, et al. Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits. Cancer Sci 2006;97: 760-7
    • (2006) Cancer Sci , vol.97 , pp. 760-767
    • Suzuki, T.1    Wakai, K.2    Matsuo, K.3
  • 39
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. Br Med J 2003;327:557-60
    • (2003) Br Med J , vol.327 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3
  • 41
    • 15944412273 scopus 로고    scopus 로고
    • Rothman KJ, ed. Epidemiology: An introduction New York: Oxford University Press
    • Rothman KJ. Measuring interactions. In: Rothman KJ, ed. Epidemiology: An introduction. New York: Oxford University Press, 2002. 168-90
    • (2002) Measuring Interactions , pp. 168-190
    • Rothman, K.J.1
  • 43
    • 12344333239 scopus 로고    scopus 로고
    • Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia
    • Almadori G, Bussu F, Galli J, et al. Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia. Cancer 2005;103:284-92
    • (2005) Cancer , vol.103 , pp. 284-292
    • Almadori, G.1    Bussu, F.2    Galli, J.3
  • 44
    • 0033808685 scopus 로고    scopus 로고
    • Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
    • Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 2000;71:121-38
    • (2000) Mol Genet Metab , vol.71 , pp. 121-138
    • Lucock, M.1
  • 45
    • 5144223373 scopus 로고    scopus 로고
    • Determining bioavailability of food folates in a controlled intervention study
    • Hannon-Fletcher MP, Armstrong NC, Scott JM, et al. Determining bioavailability of food folates in a controlled intervention study. Am J Clin Nutr 2004;80:911-8
    • (2004) Am J Clin Nutr , vol.80 , pp. 911-918
    • Hannon-Fletcher, M.P.1    Armstrong, N.C.2    Scott, J.M.3
  • 46
    • 84907280487 scopus 로고    scopus 로고
    • Folate intake and the risk of upper gastrointestinal cancers: A systematic review and meta-analysis
    • Tio M, Andrici J, Cox MR, et al. Folate intake and the risk of upper gastrointestinal cancers: A systematic review and meta-analysis. J Gastroenterol Hepatol 2014;29:250-8
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 250-258
    • Tio, M.1    Andrici, J.2    Cox, M.R.3
  • 47
    • 0032713838 scopus 로고    scopus 로고
    • Folic acid deficiency and cancer: Mechanisms of DNA instability
    • Duthie SJ. Folic acid deficiency and cancer: Mechanisms of DNA instability. Br Med Bull 1999;55:578-92
    • (1999) Br Med Bull , vol.55 , pp. 578-592
    • Duthie, S.J.1
  • 48
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R. Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 1997; 78:523-6
    • (1997) Thromb Haemost , vol.78 , pp. 523-526
    • Rozen, R.1
  • 49
    • 0034190659 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review
    • Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review. Am J Epidemiol 2000; 151:862-77
    • (2000) Am J Epidemiol , vol.151 , pp. 862-877
    • Botto, L.D.1    Yang, Q.2
  • 50
    • 30444442971 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population
    • Graziano F, Kawakami K, Ruzzo A, et al. Methylenetetrahydrofolate reductase 677C/T gene polymorphism, gastric cancer susceptibility and genomic DNA hypomethylation in an at-risk Italian population. Int J Cancer 2006;118:628-32
    • (2006) Int J Cancer , vol.118 , pp. 628-632
    • Graziano, F.1    Kawakami, K.2    Ruzzo, A.3
  • 51
    • 0037322022 scopus 로고    scopus 로고
    • Mendelian randomization' can genetic epidemiology contribute to understanding environmental determinants of disease?
    • Smith GD, Ebrahim S. 'Mendelian randomization': Can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22
    • (2003) Int J Epidemiol , vol.32 , pp. 1-22
    • Smith, G.D.1    Ebrahim, S.2
  • 52
    • 56349130046 scopus 로고    scopus 로고
    • Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer
    • Boccia S, Boffetta P, Brennan P, et al. Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. Cancer Lett 2009;273:55-61
    • (2009) Cancer Lett , vol.273 , pp. 55-61
    • Boccia, S.1    Boffetta, P.2    Brennan, P.3
  • 53
    • 84861719802 scopus 로고    scopus 로고
    • Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: A meta-analysis
    • Zhuo X, Ling J, Zhou Y, et al. Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: A meta-analysis. Cancer Invest 2012;30:447-52
    • (2012) Cancer Invest , vol.30 , pp. 447-452
    • Zhuo, X.1    Ling, J.2    Zhou, Y.3
  • 54
    • 22744434433 scopus 로고    scopus 로고
    • Causation and causal inference in epidemiology
    • Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health 2005;95:S144-50
    • (2005) Am J Public Health , vol.95 , pp. S144-A150
    • Rothman, K.J.1    Greenland, S.2
  • 55
    • 0030870862 scopus 로고    scopus 로고
    • An assessment, and reproducibility of food frequency data provided by hospital controls
    • D'Avanzo B, La Vecchia C, Katsouyanni K, et al. An assessment, and reproducibility of food frequency data provided by hospital controls. Eur J Cancer Prev 1997;6:288-93.
    • (1997) Eur J Cancer Prev , vol.6 , pp. 288-293
    • D'Avanzo, B.1    La Vecchia, C.2    Katsouyanni, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.