Inhibitory Effects of Rutin on the Endothelial Protein C Receptor Shedding In Vitro and In Vivo

Inflammation

Volumn 37, Issue 5, 2014, Pages 1424-1431

  Ku, Sae Kwang ^a   Lee, In Chul ^b   Han, Min Su ^c   Bae, Jong Sup ^d  

^a Daegu Haany University   (South Korea)

^b Seowon University   (South Korea)

^c Daegu Fatima Hospital   (South Korea)

^d Kyungpook National University   (South Korea)

Author keywords

CLP; EPCR shedding; PMA; rutin

Indexed keywords

ENDOTHELIAL PROTEIN C RECEPTOR; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE ACTIVATED RECEPTOR 1; RUTOSIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CELL SURFACE RECEPTOR; PROCR PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CECAL LIGATION AND PUNCTURE; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INVESTIGATIVE PROCEDURES; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPTICEMIA; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM;

FAGOPYRUM TATARICUM;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; RUTIN;

EID: 84918811609     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9866-5     Document Type: Article

References (39)

1. Fukudome, K., and C.T. Esmon. 1994. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. Journal of Biological Chemistry 269: 26486–26491.
2. Fukudome, K., S. Kurosawa, D.J. Stearns-Kurosawa, X. He, A.R. Rezaie, and C.T. Esmon. 1996. The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. Journal of Biological Chemistry 271: 17491–17498.
3. Mosnier, L.O., B.V. Zlokovic, and J.H. Griffin. 2007. The cytoprotective protein C pathway. Blood 109: 3161–3172.
4. Kurosawa, S., D.J. Stearns-Kurosawa, C.W. Carson, A. D'Angelo, P. Della Valle, and C.T. Esmon. 1998. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 91: 725–727.
5. Kurosawa, S., D.J. Stearns-Kurosawa, N. Hidari, and C.T. Esmon. 1997. Identification of functional endothelial protein C receptor in human plasma. Journal of Clinical Investigation 100: 411–418.
6. Liaw, P.C., P.F. Neuenschwander, M.D. Smirnov, and C.T. Esmon. 2000. Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. Journal of Biological Chemistry 275: 5447–5452.
7. Stearns-Kurosawa, D.J., K. Swindle, A. D'Angelo, et al. 2002. Plasma levels of endothelial protein C receptor respond to anticoagulant treatment. Blood 99: 526–530.
8. Xu, J., D. Qu, N.L. Esmon, and C.T. Esmon. 2000. Metalloproteolytic release of endothelial cell protein C receptor. Journal of Biological Chemistry 275: 6038–6044.
9. Wang, L., J.A. Bastarache, N. Wickersham, X. Fang, M.A. Matthay, and L.B. Ware. 2007. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. American Journal of Respiratory Cell and Molecular Biology 36: 497–503.
10. Perez-Casal, M., C. Downey, K. Fukudome, G. Marx, and C.H. Toh. 2005. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 105: 1515–1522.
11. Scaldaferri, F., M. Sans, S. Vetrano, et al. 2007. Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. Journal of Clinical Investigation 117: 1951–1960.
12. Aggarwal, B.B., H. Ichikawa, P. Garodia, et al. 2006. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opinion on Therapeutic Targets 10: 87–118.
13. Ushida, Y., T. Matsui, M. Tanaka, et al. 2008. Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta. Journal of Nutrition and Biochemistry 19: 700–707.
14. Knekt, P., J. Kumpulainen, R. Jarvinen, et al. 2002. Flavonoid intake and risk of chronic diseases. American Journal of Clinical Nutrition 76: 560–568.
15. Guo, R., P. Wei, and W. Liu. 2007. Combined antioxidant effects of rutin and vitamin C in Triton X-100 micelles. Journal of Pharmaceutical and Biomedical Analysis 43: 1580–1586.
16. Korkmaz, A., and D. Kolankaya. 2010. Protective effect of rutin on the ischemia/reperfusion induced damage in rat kidney. Journal of Surgical Research 164: 309–315.
17. Milde, J., E.F. Elstner, and J. Grassmann. 2004. Synergistic inhibition of low-density lipoprotein oxidation by rutin, gamma-terpinene, and ascorbic acid. Phytomedicine 11: 105–113.
18. Lee, W., S.K. Ku, and J.S. Bae. 2012. Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo. Food and Chemical Toxicology 50: 3048–3055.
19. Borgel, D., C. Bornstain, P.H. Reitsma, et al. 2007. A comparative study of the protein C pathway in septic and nonseptic patients with organ failure. American Journal of Respiratory and Critical Care Medicine 176: 878–885.
20. Bae, J.S., and A.R. Rezaie. 2011. Activated protein C inhibits high mobility group box 1 signaling in endothelial cells. Blood 118: 3952–3959.
21. Kim, D.C., W. Lee, and J.S. Bae. 2011. Vascular anti-inflammatory effects of curcumin on HMGB1-mediated responses in vitro. Inflammation Research 60: 1161–1168.
22. Wang, H., H. Liao, M. Ochani, et al. 2004. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nature Medicine 10: 1216–1221.
23. Qu, D., Y. Wang, Y. Song, N.L. Esmon, and C.T. Esmon. 2006. The Ser219–Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype. Journal of Thrombosis and Haemostasis 4: 229–235.
24. Qu, D., Y. Wang, N.L. Esmon, and C.T. Esmon. 2007. Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. Journal of Thrombosis and Haemostasis 5: 395–402.
25. Menschikowski, M., A. Hagelgans, G. Eisenhofer, and G. Siegert. 2009. Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways. Experimental Cell Research 315: 2673–2682.
26. Michie, H.R., K.R. Manogue, D.R. Spriggs, et al. 1988. Detection of circulating tumor necrosis factor after endotoxin administration. New England Journal of Medicine 318: 1481–1486.
27. Kremer, J.P., D. Jarrar, U. Steckholzer, and W. Ertel. 1996. Interleukin-1, −6 and tumor necrosis factor-alpha release is down-regulated in whole blood from septic patients. Acta Haematologica 95: 268–273.
28. Yang, E.J., S.K. Ku, W. Lee, et al. 2013. Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo. Journal of Cellular Physiology 228: 975–982.
29. Buras, J.A., B. Holzmann, and M. Sitkovsky. 2005. Animal models of sepsis: setting the stage. Nature Reviews Drug Discovery 4: 854–865.
30. Yang, H., M. Ochani, J. Li, et al. 2004. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proceedings of the National Academy of Sciences of the United States of America 101: 296–301.
31. Han, H., B. Du, X. Pan, et al. 2010. CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation. Molecular Cancer Research 8: 1477–1488.
32. Leng, Y., T.L. Steiler, and J.R. Zierath. 2004. Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice. Diabetes 53: 1436–1444.
33. Sesin, C.A., X. Yin, C.T. Esmon, J.P. Buyon, and R.M. Clancy. 2005. Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence. Kidney International 68: 110–120.
34. Ware, L.B., E. Camerer, K. Welty-Wolf, M.J. Schultz, and M.A. Matthay. 2006. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology 291: L307–L311.
35. Esmon, C.T. 2005. The interactions between inflammation and coagulation. British Journal of Haematology 131: 417–430.
36. Bae, J.S., L. Yang, and A.R. Rezaie. 2007. Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America 104: 2867–2872.
37. van Hylckama Vlieg, A., R. Montes, F.R. Rosendaal, and J. Hermida. 2007. Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis. Journal of Thrombosis and Haemostasis 5: 1449–1454.
38. Montes, R., V. Hurtado, A. Alonso, et al. 2005. Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women. Journal of Thrombosis and Haemostasis 3: 1454–1458.
39. Hurtado, V., R. Montes, J.C. Gris, et al. 2004. Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death. Blood 104: 1369–1374.