Clofazimine analogs with antileishmanial and antiplasmodial activity

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 1, 2015, Pages 55-65

  Barteselli, Anna ^a   Casagrande, Manolo ^a   Basilico, Nicoletta ^a   Parapini, Silvia ^a   Rusconi, Chiara M ^a   Tonelli, Michele ^b   Boido, Vito ^b   Taramelli, Donatella ^a   Sparatore, Fabio ^b   Sparatore, Anna ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Antileishmanial activity; Antiplasmodial activity; Clofazimine; Clofazimine analogs; Pyrrolizidinyl alkyliminophenazine derivatives; Quinolizidinyl alkyliminophenazine derivatives

Indexed keywords

2 [OMEGA(OCTAHYDRO 1H QUINOLIZIN 9A YL)ALKYL]ISOINDOLINE 1,3 DIONE; 3 IMINO 5 PHENYL N (PYRIDIN 3 YL) 3,5 DIHYDROPHENAZIN 2 AMINE; 3 IMINO N (6 METHOXYPYRIDIN 3 YL) 5 PHENYL 3,5 DIHYDROPHENAZIN 2 AMINE; 3 IMINO N (PYRIDIN 3 YL) 5 (PHENYL) 3,5 DIHYDROPHENAZIN 2 AMINE; 3 [(HEXAHYDRO 1H PYRROLIZIN 7A YL)METHYLIMINO] N,5 DIPHENYL 3,5 DIHYDROPHENAZIN 2 AMINE; 3 [4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)BUTYLIMINO] N,5 DIPHENYL 3,5 DIHYDROPHENAZIN 2 AMINE; 3 [6 (OCTAHYDRO 1H QUINOLIZIN 9A YL)HEXYLIMINO] N,5 DIPHENYL 3,5 DIHYDROPHENAZIN 2 AMINE; 3 [[4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)BUTYL]IMINO] 5 PHENYL N (PYRIDIN 3 YL) 3,5 DIHYDROPHENAZIN 2 AMINE; 4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)BUTAN 1 OL; 5 (4 CHLOROPHENYL) 3 IMINO N (PYRIDIN 3 YL) 3,5 DIHYDROPHENAZIN 2 AMINE; 5 (4 CHLOROPHENYL) 3 [[4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)BUTYL]IMINO] N (PYRIDIN 3 YL) 3,5 DIHYDROPHENAZIN 2 AMINE; 6 (OCTAHYDRO 1H QUINOLIZIN 9A YL)HEXAN 1 OL; 9A (ALKYLENYL)OCTAHYDRO 1H QUINOLIZINE; 9A (BUT 3 ENYL)OCTAHYDRO 1H QUINOLIZINE; 9A (HEX 5 ENYL)OCTAHYDRO 1H QUINOLIZINE; AMPHOTERICIN B; CHLOROQUINE; CLOFAZIMINE; CLOFAZIMINE DERIVATIVE; N (6 METHOXYPYRIDIN 3 YL) 3 [[4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)BUTYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZIN 2 AMINE; N,5 BIS(4 CHOROPHENYL) 3 [(HEXAHYDRO 1H PYRROLIZIN 7A YL)METHYLIMINO] 3,5 DIHYDROPHENAZIN 2 AMINE; N,5 BIS(4 FLUOROPHENYL) 3 [4 (OCTAHYDRO 1H QUINOLIZIN 9A YL)METHYLIMINO] 3,5 DIHYDROPHENAZIN 2 AMINE; N,5 BIS(4 FLUOROPHENYL) 3 [6 (OCTAHYDRO 1H QUINOLIZIN 9A YL)HEXYLIMINO] 3,5 DIHYDROPHENAZIN 2 AMINE; N1 (4 CHLOROPHENYL) N2 [2,4 DINITRO 5 (PYRIDIN 3 YLAMINO)PHENYL]BENZENE 1,2 DIAMINE; N1 BIS(4 CHLOROPHENYL) N2 (5 FLUORO 2,4 DINITROPHENYL)BENZENE 1,2 DIAMINE; N1 BIS(PHENYL) N2 [2,4 DINITRO 5 (PYRIDIN 3 YLAMINO)PHENYL]BENZENE 1,2 DIAMINE; N1 [10 (4 CHLOROPHENYL) 3 (PYRIDIN 3 YLAMINO)PHENAZIN 2(10H)YLIDENE] N3,N3 DIMETHYLPROPANE 1,3 DIAMINE; N1 [5 (6 METHOXYPYRIDIN 3 YLAMINO) 2,4 DINITROPHENYL] N2 PHENYLBENZENE 1,2 DIAMINE; OMEGA(OCTAHYDRO 1H QUINOLIZIN 9A YL)ALKAN 1 OL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFLAMMATORY AGENT; ANTIMALARIAL AGENT; ANTIPROTOZOAL AGENT;

ANTHELMINTIC ACTIVITY; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA INFANTUM; LEISHMANIA TROPICA; NONHUMAN; PLASMODIUM FALCIPARUM; PROMASTIGOTE; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENDOTHELIUM CELL;

PLASMODIUM FALCIPARUM;

ANTI-INFLAMMATORY AGENTS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; CELL LINE; CLOFAZIMINE; ENDOTHELIAL CELLS; HUMANS; LEISHMANIA; PLASMODIUM FALCIPARUM;

EID: 84918805853     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.11.028     Document Type: Article

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