Expedient synthesis of MLN1251, a CCR5 antagonist for treatment of HIV

Organic Process Research and Development

Volumn 11, Issue 2, 2007, Pages 241-245

  Rönn, Magnus ^a,b   McCubbin, Quentin ^a   Winter, Steve ^a   Veige, Melanie K ^a   Grimster, Neil ^a   Alorati, Tony ^a   Plamondon, Louis ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b TetraPhase Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34247276628     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op060245h     Document Type: Article

References (17)

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13. From chiral reduction of the corresponding ketone, ee > 98%.
14. Made by chiral reduction of the corresponding ketone in kilogram quantities.
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17. WARNING; This reaction is potentially hazardous and should be examined very carefully before using it at any scale.