Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 24, 2014, Pages 6837-6845

  Tonelli, Michele ^a   Novelli, Federica ^a   Tasso, Bruno ^a   Sparatore, Anna ^b   Boido, Vito ^a   Sparatore, Fabio ^a   Cannas, Sara ^c   Molicotti, Paola ^c   Zanetti, Stefania ^c   Parapini, Silvia ^b   Loddo, Roberta ^d  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Antitubercular activity; Clinical isolates of Mycobacterium; derivatives; Mycobacterium avium; Mycobacterium tuberculosis; Quinolizidinyl and pyrrolizidinylalkyliminophenazine; tuberculosis

Indexed keywords

2 (4 CHLOROANILINO) 5 (4 CHLOROPHENYL) 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)ETHYL]IMINO] 3,5 DIHYDROPHENAZINE; 2 (4 CHLOROANILINO) 5 (4 CHLOROPHENYL) 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)METHYL]IMINO] 3,5 DIHYDROPHENAZINE; 2 (4 CHLOROANILINO) 5 (4 CHLOROPHENYL) 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)PROPYL]IMINO] 3,5 DIHYDROPHENAZINE; 2 (4 CHLOROANILINO) 5 (4 CHLOROPHENYL) [3 [(2 HEXAHYDRO 1H PYRROLIZIN 7A YL)ETHYL]IMINO] 3,5 DIHYDROPHENAZINE; 2 ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)ETHYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; 2 ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)METHYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; 2 ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)PROPYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; 2 ANILINO 3 [[2 (HEXAHYDRO 1H PYRROLIZIN 7A YL)ETHYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)METHYL]IMINO] 2 (4 TOLYLAMINO) 5 (4 TOLYL) 3,5 DIHYDROPHENAZINE; ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)ETHYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)METHYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; ANILINO 3 [[(OCTAHYDRO 2H QUINOLIZIN 1 YL)PROPYL]IMINO] 5 PHENYL 3,5 DIHYDROPHENAZINE; CLOFAZIMINE; ETHAMBUTOL; ISONIAZID; PHENAZINE DERIVATIVE; PYRROLIZIDINYLALKYLIMINOPHENAZINE DERIVATIVE; QUINOLIZIDINYLALKYLIMINOPHENAZINE DERIVATIVE; RIFAMPICIN; STREPTOMYCIN; UNCLASSIFIED DRUG; PYRROLIDINE DERIVATIVE; QUINOLIZIDINE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; VERO CELL LINE;

MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; PHENAZINES; PYRROLIDINES; QUINOLIZIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBERCULOSIS; VERO CELLS;

EID: 84913539715     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.10.035     Document Type: Article

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