Structural elucidation of the binding site and mode of inhibition of Li+ and Mg2+ in inositol monophosphatase

FEBS Journal

Volumn 281, Issue 23, 2014, Pages 5309-5324

  Dutta, Anirudha ^a   Bhattacharyya, Sudipta ^a   Dutta, Debajyoti ^a   Das, Amit Kumar ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Bipolar disorder; Crystal structure; Inositol monophosphatase; Lithium ion inhibition; Post catalytic inhibition

Indexed keywords

INOSITOL MONOPHOSPHATASE; LITHIUM ION; MAGNESIUM ION; PHOSPHATASE; UNCLASSIFIED DRUG; LITHIUM; MAGNESIUM; MYO-INOSITOL-1 (OR 4)-MONOPHOSPHATASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; STAPHYLOCOCCUS; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM;

BINDING SITES; LITHIUM; MAGNESIUM; PHOSPHORIC MONOESTER HYDROLASES;

EID: 84918782375     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13070     Document Type: Article

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