Mobile loop mutations in an archaeal inositol monophosphatase: Modulating three-metal ion assisted catalysis and lithium inhibition

Protein Science

Volumn 19, Issue 2, 2010, Pages 309-318

  Li, Zheng ^a   Stieglitz, Kimberly A ^b   Shrout, Anthony L ^c   Wei, Yang ^a   Weis, Robert M ^c   Stec, Boguslaw ^d   Roberts, Mary F ^a  

^a BOSTON COLLEGE   (United States)

^b Roxbury Community College ^*  (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Inositol monophosphatase; Lithium inhibition; Magnesium binding; Metal assisted catalysis; Mobile loop; Mutagenesis

Indexed keywords

INOSITOL MONOPHOSPHATASE; LITHIUM ION; MAGNESIUM ION; PHOSPHATASE; UNCLASSIFIED DRUG;

ARCHAEBACTERIUM; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; METHANOCOCCUS JANNASCHII; NONHUMAN; PRIORITY JOURNAL;

BIOCATALYSIS; CATIONS, DIVALENT; ENZYME INHIBITORS; LITHIUM; MAGNESIUM; METHANOCOCCALES; MODELS, MOLECULAR; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

ARCHAEA; METHANOCALDOCOCCUS JANNASCHII;

EID: 76749140089     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.315     Document Type: Article

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