Activation of PPAR-γ by pioglitazone attenuates oxidative stress in aging rat cerebral arteries through upregulating UCP2

Journal of Cardiovascular Pharmacology

Volumn 64, Issue 6, 2014, Pages 497-506

  Wang, Peijian ^a   Li, Binghu ^b   Cai, Guocai ^a   Huang, Mingqing ^c   Jiang, Licheng ^a   Pu, Jing ^a   Li, Lu ^a   Wu, Qi ^a   Zuo, Li ^a   Wang, Qiulin ^a   Zhou, Peng ^a  

^a FIRST AFFILIATED HOSPITAL   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Aging; Cerebrovascular; Oxidative stress; Peroxisome proliferator activated receptor gamma; Pioglitazone; Uncoupling protein 2

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2;

AGING; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN ARTERY; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; RAT; UPREGULATION; WESTERN BLOTTING; AGONISTS; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

AGING; ANIMALS; CEREBRAL ARTERIES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHORYLATION; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; THIAZOLIDINEDIONES; UP-REGULATION;

EID: 84918593896     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000143     Document Type: Article

References (37)

1. Ross GW, Petrovitch H, White LR, et al. Characterization of risk factors for vascular dementia: The Honolulu-Asia Aging Study. Neurology. 1999; 53:337-343.
2. Han MK, Huh Y, Lee SB, et al. Prevalence of stroke and transient ischemic attack in Korean elders: findings from the Korean Longitudinal Study on Health and Aging (KLoSHA). Stroke. 2009;40:966-969.
3. Bachschmid MM, Schildknecht S, Matsui R, et al. Vascular aging: chronic oxidative stress and impairment of redox signalingconsequences for vascular homeostasis and disease. Ann Med. 2012;45: 17-36.
4. Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res. 2012;35:1039-1047.
5. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res. 2005;66:286-294.
6. Ye P, Zhang XJ, Wang ZJ, et al. Effect of aging on the expression of peroxisome proliferator-activated receptor gamma and the possible relation to insulin resistance. Gerontology. 2006;52:69-75.
7. Blanquicett C, Kang BY, Ritzenthaler JD, et al. Oxidative stress modulates PPAR gamma in vascular endothelial cells. Free Radic Biol Med. 2010;48:1618-1625.
8. Rajagopalan R, Perez A, Ye Z, et al. Pioglitazone is effective therapy for elderly patients with type 2 diabetes mellitus. Drugs Aging. 2004;21: 259-271.
9. Pelzer T, Jazbutyte V, Arias-Loza PA, et al. Pioglitazone reverses downregulation of cardiac PPAR gamma expression in Zucker diabetic fatty rats. Biochem Biophys Res Commun. 2005;329:726-732.
10. Jafari M, Khodayari B, Felgner J, et al. Pioglitazone: An anti-diabetic compound with anti-aging properties. Biogerontology. 2007;8:639-651.
11. Nomura H, Yamawaki H, Mukohda M, et al. Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J Pharmacol Sci. 2008;108:258-265.
12. Brannian JD, Eyster KM, Weber M, et al. Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice. Reprod Biol Endocrinol. 2008;6:10.
13. Cipolla MJ, Bishop N, Vinke RS, et al. PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats. Stroke. 2010;41:1266-1270.
14. Shimokawa T, Kato M, Watanabe Y, et al. In vivo effects of pioglitazone on uncoupling protein-2 and -3 mRNA levels in skeletal muscle of hyperglycemic KK mice. Biochem Biophys Res Commun. 1998;251: 374-378.
15. Chan SH, Wu KL, Kung PS, et al. Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertension. 2010;55:1444-1453.
16. Cabrera JA, Ziemba EA, Colbert R, et al. Uncoupling protein-2 expression and effects on mitochondrial membrane potential and oxidant stress in heart tissue. Transl Res. 2012;159:383-390.
17. Yang H, Hirooka K, Fukuda K, et al. Neuroprotective effects of angiotensin II type 1 receptor blocker in a rat model of chronic glaucoma. Invest Ophthalmol Vis Sci. 2009;50:5800-5804.
18. Pu Y, Zhang H, Wang P, et al. Dietary curcumin ameliorates agingrelated cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway. Cell Physiol Biochem. 2013;32:1167-1177.
19. Ma S, Ma L, Yang D, et al. Uncoupling protein 2 ablation exacerbates high-salt intake-induced vascular dysfunction. Am J Hypertens. 2010;23: 822-828.
20. Hoffmann J, Haendeler J, Aicher A, et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res. 2001;89:709-715.
21. Hao X, Chen J, Luo Z, et al. TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice. Pflugers Arch. 2011;461: 345-353.
22. Zhao Z, Luo Z, Wang P, et al. Rosiglitazone restores endothelial dysfunction in a rat model of metabolic syndrome through PPAR gammaand PPAR delta-dependent phosphorylation of Akt and eNOS. PPAR Res. 2011;2011:291656.
23. Vasilevko V, Passos GF, Quiring D, et al. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Ann N Y Acad Sci. 2010;1207:58-70.
24. Dobrian AD, Schriver SD, Khraibi AA, et al. Pioglitazone prevents hypertension and reduces oxidative stress in diet-induced obesity. Hypertension. 2004;43:48-56.
25. Toda N, Ayajiki K, Okamura T. Cerebral blood flow regulation by nitric oxide: recent advances. Pharmacol Rev. 2009;61:62-97.
26. Toda N, Ayajiki K, Okamura T. Cerebral blood flow regulation by nitric oxide in neurological disorders. Can J Physiol Pharmacol. 2009;87: 581-594.
27. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38: 274-279.
28. Omae T, Nagaoka T, Tanano I, et al. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Invest Ophthalmol Vis Sci. 2011;52:6749-6756.
29. Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: A randomized controlled trial. JAMA. 2005;293:1338-1347.
30. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: The Physicians' Health Study II randomized controlled trial. JAMA. 2008;300: 2123-2133.
31. Andrews ZB, Horvath TL. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab. 2009;296:E621-E627.
32. Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005;2:85-93.
33. Tian XY, Wong WT, Xu A, et al. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res. 2012;110: 1211-1216.
34. Chan SH, Wu CA, Wu KL, et al. Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stressassociated neurogenic hypertension. Circ Res. 2009;105:886-896.
35. Viguerie-Bascands N, Saulnier-Blache JS, Dandine M, et al. Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes. Biochem Biophys Res Commun. 1999;256: 138-141.
36. Bagi Z, Koller A, Kaley G. PPAR gamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. Am J Physiol Heart Circ Physiol. 2004;286: H742-H748.
37. Miller AA, Drummond GR, Schmidt HH, et al. NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res. 2005;97:1055-1062.