Light-induced retinal injury enhanced neurotrophins secretion and neurotrophic effect of mesenchymal stem cells in vitro

Arquivos Brasileiros de Oftalmologia

Volumn 76, Issue 2, 2013, Pages 105-110

  Xu, Wei ^a   Wang, Xiaoting ^a   Xu, Guoxing ^a,b   Guo, Jian ^a,b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Fujian Institute of Ophthalmology   (China)

Author keywords

Brain derived neurotrophic factor; Ciliary neurotrophic factor; Fibroblast growth factor 2; Mesenchymal stromal cells; Retina injuries; Stem cells

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR; NERVE GROWTH FACTOR;

ANIMAL; ARTICLE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; INJURY; LIGHT; MESENCHYMAL STROMA CELL; METABOLISM; RADIATION EXPOSURE; RANDOMIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTORS; LIGHT; MESENCHYMAL STROMAL CELLS; NERVE GROWTH FACTORS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RETINA;

EID: 84883162905     PISSN: 00042749     EISSN: 16782925     Source Type: Journal    
DOI: 10.1590/S0004-27492013000200010     Document Type: Article

References (24)

1. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002;418(6893):41-9. Comment in: Nature. 2002;418(6893):1. Nature. 2002;418(6893): 25-7. Nature. 2007;447(7146):763.
2. Kicic A, Shen WY, Wilson AS, Constable IJ, Robertson T, Rakoczy PE. Differentiation of marrow stromal cells into photoreceptors in the rat eye. J Neurosci. 2003;23(21): 7742-9.
3. Castanheira P, Torquetti L, Nehemy MB, Goes AM. Retinal incorporation and differentiation of mesenchymal stem cells intravitreally injected in the injured retina of rats. Arq Bras Oftalmol. 2008;71(5):644-50.
4. Ratajczak MZ, Zuba-Surma EK, Machalinski B, Ratajczak J, Kucia M. Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance. Stem Cell Rev. 2008;4(2):89-99.
5. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008;3(3):301-13. Comment in: Cell Stem Cell. 2008;3(3):229-30.
6. Uccelli A, Laroni A, Freedman MS. Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol. 2011;10(7):649-56.
7. Harper MM, Adamson L, Blits B, Bunge MB, Grozdanic SD, Sakaguchi DS. Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res. 2009;89(4):538-48.
8. Johnson TV, Bull ND, Hunt DP, Marina N, Tomarev SI, Martin KR. Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest Ophthalmol Vis Sci [Internet]. 2010[cited 2012 Jan 3];51(4):2051-9.Available from: http://www.iovs.org/cgi/pmidlookup?view=long&pmid=19933193
9. Wang S, Lu B, Girman S, Duan J, McFarland T, Zhang QS, et al. Non-invasive stem cell therapy in a rat model for retinal degeneration and vascular pathology. PLoS One. 2010;5(2):e9200.
10. Zhang Y, Wang W. Effects of bone marrow mesenchymal stem cell transplantation on light-damaged retina. Invest Ophthalmol Vis Sci [Internet]. 2010[cited 2011 Jun 21];51(7):3742-8.Available from: http://www.iovs.org/cgi/pmidlookup?view=long&p mid=20207980
11. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402-8.
12. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101-8.
13. Xu W, Xu GX. Mesenchymal stem cells for retinal diseases. Int J Ophthalmol. 2011; 4(4):413-21.
14. Stappenbeck TS, Miyoshi H. The role of stromal stem cells in tissue regeneration and wound repair. Science. 2009;324(5935):1666-9.
15. Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011;9(1):11-5.
16. Joly S, Pernet V, Chemtob S, Di Polo A, Lachapelle P. Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF. Invest Ophthalmol Vis Sci [Internet]. 2007[cited 2012 Jul 21];48(5):2311-20. Available from: http://www.iovs.org/content/48/5/2311.long
17. Valter K, Bisti S, Gargini C, Di Loreto S, Maccarone R, Cervetto L, et al. Time course of neurotrophic factor upregulation and retinal protection against light-induced damage after optic nerve section. Invest Ophthalmol Vis Sci [Internet]. 2005[cited 2010 Jul 21];46(5):1748-54.Available from: http://www.iovs.org/content/46/5/1748.long
18. Saito T, Abe T, Wakusawa R, Sato H, Asai H, Tokita-Ishikawa Y, et al. TrkB-T1 receptors on Muller cells play critical role in brain-derived neurotrophic factor-mediated photoreceptor protection against phototoxicity. Curr Eye Res. 2009;34(7):580-8.
19. Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res. 2010; 20(6):728-31.
20. Bull ND, Johnson TV, Welsapar G, DeKorver NW, Tomarev SI, Martin KR. Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies. Invest Ophthalmol Vis Sci [Internet]. 2011[cited 2012 Oct 21]; 52(6):3309-20.Available from: http://www.iovs.org/content/52/6/3309.long
21. Inoue Y, Iriyama A, Ueno S, Takahashi H, Kondo M, Tamaki Y, et al. Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration. Exp Eye Res. 2007;85(2):234-41.
22. Choi YJ, Li WY, Moon GJ, Lee PH, Ahn YH, Lee G, et al. Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with trophic factors. J Neurol Sci. 2010; 298(1-2):28-34.
23. Sun X, Ge J, Jiang R, Duan S, Song G, Duan Y, et al. Induced differentiation of bone marrow mesenchymal stem cells towards retinal ganglion precursor cells. Cell Res. 2008;18(s76).
24. Liu DN, Yin ZQ, Wu N, Wang YH, Chen LF. Rat bone marrow stromal cells express retinal phenotypic markers following different induction protocols. Ophthalmic Res. 2009;41(4):186-93.