Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase

Analytical Chemistry

Volumn 80, Issue 7, 2008, Pages 2599-2605

  Wang, Yuesong ^a   Gatti, Paula ^a   Sadílek, Martin ^a   Scott, C Ronald ^b   Tureček, František ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; MITOCHONDRIA;

DECARBOXYLATION; ERYTHROCYTES; PORPHYRIAS; UROPORPHYRINOGEN DECARBOXYLASE;

ENZYMES;

COPROPORPHYRINOGEN; COPROPORPHYRINOGEN OXIDASE; HEME; PORPHYRINOGEN; PROTOPORPHYRIN; UROPORPHYRINOGEN; UROPORPHYRINOGEN DECARBOXYLASE;

ARTICLE; BIOLOGICAL MONITORING; CATALYSIS; CONTROLLED STUDY; COPROPORPHYRIA; DECARBOXYLATION; DIAGNOSTIC VALUE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ERYTHROCYTE; GENETIC DISORDER; HEME SYNTHESIS; HUMAN; HUMAN CELL; LIQUID LIQUID EXTRACTION; LYMPHOCYTE; OXIDATION; PORPHYRIA CUTANEA TARDA; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

AEROBIOSIS; COPROPORPHYRINOGEN OXIDASE; HEME; HUMANS; MOLECULAR STRUCTURE; PORPHYRIAS; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; UROPORPHYRINOGEN DECARBOXYLASE;

EID: 41849123890     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac702130n     Document Type: Article

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