A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C

Journal of Hepatology

Volumn 62, Issue 1, 2015, Pages 31-40

  Owusu Sekyere, Solomon ^a   Suneetha, Pothakamuri Venkata ^a   Kraft, Anke Renate Maria ^a   Zhang, Shihong ^a   Dietz, Julia ^b   Sarrazin, Christoph ^b   Manns, Michael Peter ^a   Schlaphoff, Verena ^a   Cornberg, Markus ^a   Wedemeyer, Heiner ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

2B4; Chronic hepatitis C; CMV; Co regulatory receptors; CTLA 4; EBV; HCV; PD 1; T cell exhaustion; TIM 3

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR 2B4; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 3; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD; CD8+ T LYMPHOCYTE; CELL HETEROGENEITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS LINKING; CYTOMEGALOVIRUS; DISEASE ACTIVITY; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; EX VIVO STUDY; FEMALE; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VITRO STUDY; LYMPHOCYTE FUNCTION; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS IMMUNITY; VIRUS LOAD; CHRONIC HEPATITIS C; GENETICS; HEPACIVIRUS; IMMUNOLOGY; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS REGULATORY PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER; MALE; MIDDLE AGED; RNA, VIRAL; VIRAL LOAD; YOUNG ADULT;

EID: 84918578346     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.08.008     Document Type: Article

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