Lipid emulsion rapidly restores contractility in stunned mouse cardiomyocytes: A comparison with therapeutic hypothermia

Critical Care Medicine

Volumn 42, Issue 12, 2014, Pages e734-e740

  Li, Jing ^a   Fettiplace, Michael ^a,b   Chen, Sy Jou ^a,c   Steinhorn, Benjamin ^a   Shao, Zuohui ^a   Zhu, Xiangdong ^a   Li, Changqing ^a   Harty, Shaun ^a   Weinberg, Guy ^a,b   Van Den Hoek, Terry L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Akt; Contractility; Erk; Intralipid; Lipid emulsion; Stunning

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ISOPRENALINE; LIPID EMULSION; TRICIRIBINE; 1,3 BUTADIENE DERIVATIVE; CARDIOTONIC AGENT; CHLORPROPAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; COOLING; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INDUCED HYPOTHERMIA; MOUSE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; REPERFUSION INJURY; VELOCITY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; ISCHEMIA; MUSCLE CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; TIME;

ANIMALS; BUTADIENES; CARDIOTONIC AGENTS; CHLORPROPAMIDE; DISEASE MODELS, ANIMAL; HYPOTHERMIA, INDUCED; ISCHEMIA; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NITRILES; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS;

EID: 84918554619     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000656     Document Type: Article

References (48)

1. Camici PG, Prasad SK, Rimoldi OE: Stunning, hibernation, and assessment of myocardial viability. Circulation 2008;117:103-114
2. Mentzer RM Jr: Myocardial protection in heart surgery. J Cardiovasc Pharmacol Ther 2011;16:290-297
3. Pomblum VJ, Korbmacher B, Cleveland S, et al: Cardiac stunning in the clinic: The full picture. Interact Cardiovasc Thorac Surg 2010;10:86-91
4. Endoh M, Hori M: Acute heart failure: Inotropic agents and their clinical uses. Expert Opin Pharmacother 2006;7:2179-2202
5. Kloner RA: Current state of clinical translation of cardioprotective agents for acute myocardial infarction. Circ Res 2013;113:451-463
6. Bernard SA, Gray TW, Buist MD, et al: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557-563
7. The Hypothermia After Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549-556
8. Zia A, Kern KB: Management of postcardiac arrest myocardial dysfunction. Curr Opin Crit Care 2011;17:241-246
9. Shao ZH, Chang WT, Chan KC, et al: Hypothermia-induced cardioprotection using extended ischemia and early reperfusion cooling. Am J Physiol Heart Circ Physiol 2007;292:H1995-H2003
10. Shao ZH, Sharp WW, Wojcik KR, et al: Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants. Am J Physiol Heart Circ Physiol 2010;298:H2164-H2173
11. Beiser DG, Wojcik KR, Zhao D, et al: Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest. Am J Physiol Heart Circ Physiol 2010;298:H1761-H1768
12. Mikkelsen ME, Christie JD, Abella BS, et al; American Heart Associationšfs Get With the Guidelines-Resuscitation Investigators: Use of therapeutic hypothermia after in-hospital cardiac arrest. Crit Care Med 2013;41:1385-1395
13. Rahman S, Li J, Bopassa JC, et al: Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury. Anesthesiology 2011;115:242-253
14. Li J, Iorga A, Sharma S, et al: Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology 2012;117:836-846
15. Jones JW, Tibbs D, McDonald LK, et al: 10% Soybean oil emulsion as a myocardial energy substrate after ischemic arrest. Surg Forum 1977;28:284-285
16. Van de Velde M, Wouters PF, Rolf N, et al: Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs. Cardiovasc Res 1996;32:1008-1015
17. Van de Velde M, DeWolff M, Leather HA, et al: Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. Cardiovasc Res 2000;48:129-137
18. Garcia-de-Lorenzo A, Lopez-Martinez J, Planas M, et al: Safety and metabolic tolerance of a concentrated long-chain triglyceride lipid emulsion in critically ill septic and trauma patients. JPEN-Parenter Enter 2003;27:208-215
19. Hiller DB, Di Gregorio G, Kelly K, et al: Safety of high volume lipid emulsion infusion: A first approximation of LD50 in rats. Reg Anesth Pain Med 2010;35:140-144
20. Mirtallo JM, Dasta JF, Kleinschmidt KC, et al: State of the art review: Intravenous fat emulsions: Current applications, safety profile, and clinical implications. Ann Pharmacother 2010;44:688-700
21. Cave G, Harvey M: Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: A systematic review. Acad Emerg Med 2009;16:815-824
22. Weinberg G, Ripper R, Feinstein DL, et al: Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003;28:198-202
23. Vanden Hoek TL, Shao Z, Li C, et al: Reperfusion injury on cardiac myocytes after simulated ischemia. Am J Physiol 1996;270:H1334-H1341
24. Willert CE, Gharib M: Digital particle image velocimetry. Exp Fluids 1991;10:181-193
25. Mouret F, Garitey V, Bertrand E, et al: In vitro atrial flow dynamics: Normal conditions versus atrial fibrillation. J Biomech 2004;37:1749-1755
26. Kamgoue A, Ohayon J, Usson Y, et al: Quantification of cardiomyocyte contraction based on image correlation analysis. Cytometry A 2009;75:298-308
27. Yin S, Chen C, Cheung J: Using optical particle image velocimetry for the nondestructive measurement of the single-cell contractile force. Microw Opt Technol Lett 1996;6:126-129
28. Ristagno G, Tantillo S, Sun S, et al: Hypothermia improves ventricular myocyte contractility under conditions of normal perfusion and after an interval of ischemia. Resuscitation 2010;81:898-903
29. Lou PH, Lucchinetti E, Zhang L, et al: The mechanism of IntralipidR-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. PLoS One 2014;9:e87205
30. Monti LD, Allibardi S, Piatti PM, et al: Triglycerides impair postischemic recovery in isolated hearts: Roles of endothelin-1 and trimetazidine. Am J Physiol Heart Circ Physiol 2001;281:H1122-H1130
31. Prinzen FW, van der Vusse GJ, Coumans WA, et al: The effect of elevated arterial free fatty acid concentrations on hemodynamics and myocardial metabolism and blood flow during ischemia. Basic Res Cardiol 1981;76:197-210
32. Kurien VA, Yates PA, Oliver MF: The role of free fatty acids in the production of ventricular arrhythmias after acute coronary artery occlusion. Eur J Clin Invest 1971;1:225-241
33. Smiseth OA, Mjos OD: Haemodynamic and metabolic consequences of elevated plasma free fatty acids during acute ischaemic left ventricular failure in dogs. Scand J Clin Lab Invest 1985;45:515-520
34. Kjekshus JK, Mjos OD: Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart. J Clin Invest 1972;51:1767-1776
35. Liedtke AJ, Nellis S, Neely JR: Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res 1978;43:652-661
36. Yellon DM, Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 2007;357:1121-1135
37. Nolan JP, Morley PT, Vanden Hoek TL, et al; International Liaison Committee on Resuscitation: Therapeutic hypothermia after cardiac arrest: An advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003;108:118-121
38. Field JM, Hazinski MF, Sayre MR, et al: Part 1: Executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010;122:S640-S656
39. Abella BS, Zhao D, Alvarado J, et al: Intra-arrest cooling improves outcomes in a murine cardiac arrest model. Circulation 2004;109:2786-2791
40. Weinberg GL, VadeBoncouer T, Ramaraju GA, et al: Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaineinduced asystole in rats. Anesthesiology 1998;88:1071-1075
41. Fettiplace MR, Akpa BS, Ripper R, et al: Resuscitation with lipid emulsion: Dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology 2014;120:915-925
42. Liu SL, Wang Y, Wang RR, et al: [Protective effect of intralipid on myocardial ischemia/reperfusion injury in isolated rat heart]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008;20:227-230
43. Dezfulian C, Shiva S, Alekseyenko A, et al: Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I. Circulation 2009;120:897-905
44. Zhao H, Sapolsky RM, Steinberg GK: Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 2006;34:249-270
45. Fettiplace MR, Ripper R, Lis K, et al: Intraosseous lipid emulsion: An effective alternative to IV delivery in emergency situations. Crit Care Med 2014;42:e157-e160
46. Fettiplace MR, Ripper R, Lis K, et al: Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013;41:e156-e162
47. Rosenblatt MA, Abel M, Fischer GW, et al: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacainerelated cardiac arrest. Anesthesiology 2006;105:217-218
48. Harvey M, Cave G, Kazemi A: Intralipid infusion diminishes return of spontaneous circulation after hypoxic cardiac arrest in rabbits. Anesth Analg 2009;108:1163-1168