Regiospecific formation of cobamide isomers is directed by CobT

Biochemistry

Volumn 53, Issue 49, 2014, Pages 7805-7815

  Crofts, Terence S ^a,c   Hazra, Amrita B ^a   Tran, Jennifer LA ^a,d   Sokolovskaya, Olga M ^b   Osadchiy, Vadim ^a   Ad, Omer ^b   Pelton, Jeffrey ^b   Bauer, Stefan ^b   Taga, Michiko E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; LIGANDS; PLANTS (BOTANY); SALMONELLA; SUBSTRATES;

ACTIVE SITE RESIDUES; BENZIMIDAZOLES; BIOLOGICAL PROCESS; GLYCOSIDIC BOND; ISOMERIC PRODUCTS; REGIOSPECIFICITY; SALMONELLA ENTERICA; SINGLE-POINT MUTATION;

ISOMERS;

5 HYDROXYBENZIMIDAZOLE; 5 METHYOXYBENZIMIDAZOLE; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; COBALT; COBAMAMIDE; COBT ENZYME; ENZYME; ETHANOLAMINE AMMONIA LYASE; NITROGEN; PHOSPHATE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; GLYCOSYLTRANSFERASE; LIGAND; MULTIENZYME COMPLEX; NICOTINATE-NUCLEOTIDE-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE; NUCLEOTIDYLTRANSFERASE; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL GROWTH; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; ENZYME ENGINEERING; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; HETEROLOGOUS EXPRESSION; ISOMER; MUTAGENESIS; NONHUMAN; POINT MUTATION; REACTION ANALYSIS; SALMONELLA ENTERICA; SINORHIZOBIUM MELILOTI; STEREOCHEMISTRY; STEREOISOMERISM; VEILLONELLA PARVULA; AMINO ACID SUBSTITUTION; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; KINETICS; METABOLISM; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; VEILLONELLA;

PROKARYOTA; SALMONELLA ENTERICA;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; COBAMIDES; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDYLTRANSFERASES; PENTOSYLTRANSFERASES; POINT MUTATION; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; SINORHIZOBIUM MELILOTI; SPECIES SPECIFICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY; VEILLONELLA;

EID: 84918547841     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501147d     Document Type: Article

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