Analysis of substrate specificity in CobT homologs reveals widespread preference for DMB, the lower axial ligand of vitamin B12

Chemistry and Biology

Volumn 20, Issue 10, 2013, Pages 1275-1285

  Hazra, Amrita B ^a   Tran, Jennifer L A ^a   Crofts, Terence S ^a   Taga, Michiko E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYLBENZIMIDAZOLE; ALPHA RIBAZOLE PHOSPHATE; BENZIMIDAZOLE DERIVATIVE; COBALAMIN; COBALT; CYANOCOBALAMIN; LIGAND; NICOTINIC ACID; PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEHALOCOCCOIDES; DESULFOVIBRIO VULGARIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE PRODUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LACTOBACILLUS REUTERI; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM FREUDENREICHII SHERMANII; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SALMONELLA ENTERICA; SINORHIZOBIUM MELILOTI; VEILLONELLA PARVULA;

PROKARYOTA;

BACTERIA; BENZIMIDAZOLES; BINDING, COMPETITIVE; COBAMIDES; LIGANDS; MULTIENZYME COMPLEXES; NUCLEOTIDYLTRANSFERASES; PENTOSYLTRANSFERASES; REPRODUCIBILITY OF RESULTS; RIBONUCLEOSIDES; SINORHIZOBIUM MELILOTI; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; VITAMIN B 12;

EID: 84886798305     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.08.007     Document Type: Article

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