GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer

Cancer Research

Volumn 74, Issue 22, 2014, Pages 6717-6730

  Emmink, Benjamin L ^a   Laoukili, Jamila ^a   Kipp, Anna P ^b   Koster, Jan ^c   Govaert, Klaas M ^a   Fatrai, Szabolcs ^a   Verheem, Andre ^a   Steller, Ernst J A ^a   Brigelius Flohé, Regina ^a   Jimenez, Connie R ^d   Rinkes, Inne H M Borel ^a   Kranenburg, Onno ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE 2; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; GLUTATHIONE PEROXIDASE; GPX2 PROTEIN, HUMAN; THIOREDOXIN REDUCTASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER GROWTH; CANCER RECURRENCE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CLONOGENESIS; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE SILENCING; GPX2 GENE; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN EXPRESSION; SENSITIZATION; ANIMAL; COLORECTAL TUMOR; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SCID MOUSE;

ANIMALS; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; MICE; MICE, SCID; NEOPLASM METASTASIS; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; THIOREDOXIN REDUCTASE 1;

EID: 84918545433     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1645     Document Type: Article

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