Exendin-4 loaded nanoparticles with a lipid shell and aqueous core containing micelles for enhanced intestinal absorption

Journal of Biomedical Nanotechnology

Volumn 11, Issue 5, 2015, Pages 865-876

  Chen, Chunhui ^a   Zhu, Xi ^a   Dou, Yanfeng ^b   Xu, Juan ^a   Zhang, Jian ^a   Fan, Tingting ^a   Du, Junrong ^a   Liu, Ke ^a   Deng, Yihong ^a   Zhao, Liyan ^b   Huang, Yuan ^a  

^a SICHUAN UNIVERSITY   (China)

^b CSPC ZhongQi Pharmaceutical Technology (Shijiazhuang) Co Ltd   (China)

Author keywords

Diabetes; Exendin 4; Micelles; Nanoparticles; Oral delivery

Indexed keywords

ENCAPSULATION; MEDICAL PROBLEMS; MICELLES;

CELLULAR UPTAKE; CENTRAL COMPOSITE DESIGNS; DRUG ENCAPSULATION EFFICIENCY; EXENDIN-4; IN-SITU STUDY; INTESTINAL ABSORPTION; ORAL DELIVERY; PREPARATION PROCESS;

NANOPARTICLES;

AMILORIDE; CHLORPROMAZINE; CHOLIC ACID; EXENDIN 4; FILIPIN; FLUORESCEIN ISOTHIOCYANATE; GLUCOSE; LYSOSOME ENZYME; NANOCARRIER; ANTIDIABETIC AGENT; DRUG CARRIER; LIPOSOME; MICELLE; NANOPARTICLE; PEPTIDE; VENOM; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG PENETRATION; DRUG SCREENING; DRUG UPTAKE; ELECTRIC CONDUCTIVITY; EXPERIMENTAL DIABETES MELLITUS; FACTORIAL DESIGN; FLUORESCENCE MICROSCOPY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTRADUODENAL DRUG ADMINISTRATION; MALE; MICELLE; MOUSE; NANOEMULSION; NANOENCAPSULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; VALIDATION PROCESS; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; MOUSE MUTANT; PATHOLOGY; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

ANIMALS; CACO-2 CELLS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; LIPOSOMES; MALE; MICE; MICE, OBESE; MICE, TRANSGENIC; MICELLES; NANOPARTICLES; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; VENOMS; WATER;

EID: 84918534643     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2015.1971     Document Type: Article

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