Exposure to varicella zoster virus is higher in children with autism spectrum disorder than in healthy controls. results from a case-control study

In Vivo

Volumn 28, Issue 4, 2014, Pages 627-632

  Gentile, Ivan ^a   Zappulo, Emanuela ^a   Bonavolta, Raffaele ^a   Maresca, Roberta ^b   Riccio, Maria Pia ^b   Buonomo, Antonio Riccardo ^a   Portella, Giuseppe ^a   Settimi, Alessandro ^a   Pascotto, Antonio ^b   Borgia, Guglielmo ^a   Bravaccio, Carmela ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Autism spectrum disorder; Etiopathogenesis; Prevalence; Titre; VZV

Indexed keywords

VIRUS ANTIBODY; IMMUNOGLOBULIN G;

ANTIBODY TITER; ARTICLE; AUTISM; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; VARICELLA ZOSTER VIRUS; ADOLESCENT; BLOOD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; HERPES ZOSTER; IMMUNOLOGY; ITALY; PREVALENCE; VIROLOGY;

ADOLESCENT; ANTIBODIES, VIRAL; CASE-CONTROL STUDIES; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; FEMALE; HERPES ZOSTER; HERPESVIRUS 3, HUMAN; HUMANS; IMMUNOGLOBULIN G; ITALY; MALE; PREVALENCE;

EID: 84918520866     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Fourth edition, Text Revision. Washington, DC, American Psychiatric Association, 2000.
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Fifth edition. Arlington, VA, American Psychiatric Publishing, 2013.
3. King CR: A novel embryological theory of autism causation involving endogenous biochemicals capable of initiating cellular gene transcription: a possible link between twelve autism risk factors and the autism 'epidemic'. Med Hypotheses 76: 653-660, 2011.
4. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention: Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ 61: 1-19, 2012.
5. Taylor B, Jick H and Maclaughlin D: Prevalence and incidence rates of autism in the UK: time trend from 2004-2010 in children aged 8 years. BMJ Open 3: e003219, 2013.
6. Benvenuto A, Moavero R, Alessandrelli R, Manzi B and Curatolo P: Syndromic autism: causes and pathogenetic pathways. World J Pediatr 5: 169-176, 2009.
7. Engel SM and Daniels JL: On the complex relationship between genes and environment in the etiology of autism. Epidemiology 22: 486-488, 2011.
8. Stagno S and Whitley RJ: Herpesvirus infections of pregnancy. Part I: Cytomegalovirus and Epstein-Barr virus infections. N Engl J Med 313: 1270-1274, 1985.
9. Gregg NM: Congenital cataract following German measles in the mother. 1941. Aust N Z J Ophthalmol 19: 267-276, 1991.
10. Garbett KA, Hsiao EY, Kalman S, Patterson PH and Mirnics K: Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl Psychiatry 2: e98, 2012.
11. Patterson PH: Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr Opin Neurobiol 12: 115-118, 2002.
12. Malkova NV, Yu CZ, Hsiao EY, Moore MJ and Patterson PH: Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun 26: 607-616, 2012.
13. Kuhn M, Grave S, Bransfield R and Harris S: Long term antibiotic therapy may be an effective treatment for children comorbid with Lyme disease and autism spectrum disorder. Med Hypotheses 78: 606-615, 2012.
14. Gentile I, Bravaccio C, Bonavolta R, Zappulo E, Scarica S, Riccio MP, Settimi A, Portella G, Pascotto A and Borgia G: Response to measles-mumps-rubella vaccine in children with autism spectrum disorders. In Vivo 27: 377-382, 2013.
15. Singh VK, Lin SX and Yang VC: Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol 89: 105-108, 1998.
16. Cannell JJ: Autism and vitamin D. Med Hypotheses 70: 750-759, 2008.
17. Grant WB and Soles CM: Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Dermatoendocrinol 1: 223-228, 2009.
18. Meguid NA, Hashish AF, Anwar M and Sidhom G: Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. J Altern Complement Med 16: 641-645, 2010.
19. Molloy CA, Kalkwarf HJ, Manning-Courtney P, Mills JL and Hediger ML: Plasma 25(OH)D concentration in children with autism spectrum disorder. Dev Med Child Neurol 52: 969-971, 2010.
20. Eyles DW, Burne TH and McGrath JJ: Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 11: 11, 2012.
21. Comi AM, Zimmerman AW, Frye VH, Law PA and Peeden JN: Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 14: 388-394, 1999.
22. Keil A, Daniels JL, Forssen U, Hultman C, Cnattingius S, Soderberg KC, Feychting M and Sparen P: Parental autoimmune diseases associated with autism spectrum disorders in offspring. Epidemiology 21: 805-808, 2010.
23. Gentile I, Zappulo E, Militerni R, Pascotto A, Borgia G and Bravaccio C: Etiopathogenesis of autism spectrum disorders: fitting the pieces of the puzzle together. Med Hypotheses 81: 26-35, 2013.
24. Deykin EY and MacMahon B: Viral exposure and autism. Am J Epidemiol 109: 628-638, 1979.
25. Libbey JE, Sweeten TL, McMahon WM and Fujinami RS: Autistic disorder and viral infections. J Neurovirol 11: 1-10, 2005.
26. Anlar B, Oktem F and Torok T: Human parvovirus B19 antibodies in infantile autism. J Child Neurol 9: 104-105, 1994.
27. Persico AM: Polyomaviruses and autism: more than simple association? Journal of Neurovirology 16: 332-333, 2010.
28. Chess S: Autism in children with congenital rubella. J Autism Child Schizophr 1: 33-47, 1971.
29. Gentile I, Altieri L, Lintas C, Sacco R, Curatolo P, Benvenuto A, Muratori F, Santocchi E, Bravaccio C, Lenti C, Faggioli R, Rigardetto R, Gandione M, Portella G, Zappulo E, Borgia G and Persico AM: Urinary polyomavirus infections in neurodevelopmental disorders. Open Journal of Psychiatry 3: 18-25, 2013.
30. Sylvester Jorgensen O, Vejlsgaard Goldschmidt V and Faber Vestergaard B: Herpes simplex virus (HSV) antibodies in child psychiatric patients and normal children. Acta Psychiatr Scand 66: 42-49, 1982.
31. Ghaziuddin M, Tsai LY, Eilers L and Ghaziuddin N: Brief report: autism and herpes simplex encephalitis. J Autism Dev Disord 22: 107-113, 1992.
32. Gillberg C: Onset at age 14 of a typical autistic syndrome. A case report of a girl with herpes simplex encephalitis. J Autism Dev Disord 16: 369-375, 1986.
33. Mora M, Quintero L, Cardenas R, Suarez-Roca H, Zavala M and Montiel N: [Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]. Invest Clin 50: 315-326, 2009.
34. Kitajima J, Inoue H, Ohga S, Kinjo T, Ochiai M, Yoshida T, Kusuhara K and Hara T: Differential transmission and postnatal outcomes in triplets with intrauterine cytomegalovirus infection. Pediatr Dev Pathol 15: 151-155, 2012.
35. Dogan Y, Yuksel A, Kalelioglu IH, Has R, Tatli B and Yildirim A: Intracranial ultrasound abnormalities and fetal cytomegalovirus infection: report of 8 cases and review of the literature. Fetal Diagn Ther 30: 141-149, 2011.
36. Stubbs EG: Autistic symptoms in a child with congenital cytomegalovirus infection. J Autism Child Schizophr 8: 37-43, 1978.
37. Markowitz PI: Autism in a child with congenital cytomegalovirus infection. J Autism Dev Disord 13: 249-253, 1983.
38. Ivarsson SA, Bjerre I, Vegfors P and Ahlfors K: Autism as one of several disabilities in two children with congenital cytomegalovirus infection. Neuropediatrics 21: 102-103, 1990.
39. Yamashita Y, Fujimoto C, Nakajima E, Isagai T and Matsuishi T: Possible association between congenital cytomegalovirus infection and autistic disorder. J Autism Dev Disord 33: 455-459, 2003.
40. Sweeten TL, Posey DJ and McDougle CJ: Brief report: autistic disorder in three children with cytomegalovirus infection. J Autism Dev Disord 34: 583-586, 2004.
41. Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, Tsukahara H and Mayumi M: Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder. Pediatr Int 52: 304-307, 2010.
42. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ and Alford CA: The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 326: 663-667, 1992.
43. Gentile I, Zappulo E, Coppola N, Bonavolta R, Portella G, Cernia DS, Riccio MP, Settimi A, Pascotto A, Borgia G and Bravaccio C: Prevalence of HHV-6 and HHV-8 Antibodies in Patients with Autism Spectrum Disorders. In Vivo 27: 843-849, 2013.
44. Lord C, Rutter M and Le Couteur A: Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24: 659-685, 1994.
45. Schopler E, Reichler RJ and Renner BR: The Childhood Autism Rating Scale (CARS). Los Angeles, CA, Western Psychological Service Inc, 1988.
46. Lord C, Risi S, Lambrecht L, Cook EH, Jr., Leventhal BL, DiLavore PC, Pickles A and Rutter M: The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30: 205-223, 2000.
47. Sparrow SS, Balla DA and Cicchetti DV: Vineland Adaptive Behavior Scales. Intervista, forma completa. Balboni G., Pedrabissi L., editors. Firenze, Italy, Giunti O.S., 1984
48. Griffiths R: GDMS-Griffiths Mental Development Scales. Firenze, Italy, Giunti O.S, 2006.
49. DeLong GR, Bean SC and Brown FR, 3rd: Acquired reversible autistic syndrome in acute encephalopathic illness in children. Arch Neurol 38: 191-194, 1981.
50. Persico AM, Van de Water J and Pardo CA: Autism: Where Genetics Meets the Immune System. Autism Res Treat 2012: 2, 2012.
51. Jyonouchi H, Sun S and Le H: Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol 120: 170-179, 2001.
52. Siniscalco D, Sapone A, Giordano C, Cirillo A, de Novellis V, de Magistris L, Rossi F, Fasano A, Maione S and Antonucci N: The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients. J Autism Dev Disord 42: 1403-1410, 2012.
53. Desmond MM, Wilson GS, Verniaud WM, Melnick JL and Rawls WE: The early growth and development of infants with congenital rubella. Adv Teratol 4: 39-63, 1970.
54. Gentile I, Talamo M and Borgia G: Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review. BMC Infect Dis 10: 49, 2010.
55. Gentile I, Bonadies G, Buonomo AR, Minei G, Borrelli F, Foggia M, Chiurazzi F and Borgia G: Resolution of autoimmune thrombocytopenia associated with raltegravir use in an HIVpositive patient. Platelets 24: 574-577, 2013.
56. Singh VK: Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism. Ann Clin Psychiatry 21: 148-161, 2009.
57. Kawashti MI, Amin OR and Rowehy NG: Possible immunological disorders in autism: concomitant autoimmunity and immune tolerance. Egypt J Immunol 13: 99-104, 2006.
58. Jankosky C, Deussing E, Gibson RL and Haverkos HW: Viruses and vitamin D in the etiology of type 1 diabetes mellitus and multiple sclerosis. Virus Res 163: 424-430, 2012.