The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients

Journal of Autism and Developmental Disorders

Volumn 42, Issue 7, 2012, Pages 1403-1410

  Siniscalco, Dario ^a,b   Sapone, Anna ^a,c   Giordano, Catia ^a   Cirillo, Alessandra ^a   De Novellis, Vito ^a   De Magistris, Laura ^a   Rossi, Francesco ^a   Fasano, Alessio ^c   Maione, Sabatino ^a   Antonucci, Nicola ^d  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Centre for Autism La Forza del Silenzio   (Italy)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d Biomedical Centre for Autism Research and Treatment   (Italy)

Author keywords

Autism spectrum disorders; Caspases; Gene expression; PBMCs

Indexed keywords

CASPASE; CASPASE 2; CASPASE 3; CASPASE 4; CASPASE 5; CASPASE 7; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA;

APOPTOSIS; ARTICLE; AUTISM; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; CASPASES; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MONOCYTES; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84863872650     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-011-1373-z     Document Type: Article

References (63)

1. Adam-Klages, S., Adam, D., Janssen, O., & Kabelitz, D. (2005). Death receptors and caspases: Role in lymphocyte proliferation, cell death, and autoimmunity. Immunologic Research, 33(2), 149-166. (Pubitemid 41457466)
2. Agard, N. J., Maltby, D., & Wells, J. A. (2010). Inflammatory stimuli regulate caspase substrate profiles. Molecular Cell Proteomics, 9(5), 880-893.
3. Aitken, S. L., Corl, C. M., & Sordillo, L. M. (2011). Pro-inflammatory and pro-apoptotic responses of TNF-a stimulated bovine mammary endothelial cells. Veterinary Immunology and Immunopathology, 140(3-4), 282-290.
4. Algeciras-Schimnich, A., Barnhart, B. C., & Peter, M. E. (2002). Apoptosis independent functions of killer caspases. Current Opinion in Cell Biology, 14, 721-726. (Pubitemid 35449384)
5. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, text revision, 4th ed. Washington, DC: American Psychiatric Press.
6. Andrianjafiniony, T., Dupré-Aucouturier, S., Letexier, D., Couchoux, H., & Desplanches, D. (2010). Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. American Journal of Physiology-Cell Physiology, 299, C307-C315.
7. Ashwood, P., Wills, S., & Van de Water, J. (2006). The immune response in autism: A new frontier for autism research. Journal of Leukocyte Biology, 80(1), 1-15. (Pubitemid 44841805)
8. Banerjee, M., Datta, M., Majumder, P., Mukhopadhyay, D., & Bhattacharyya, N. P. (2010). Transcription regulation of caspase- 1 by R393 of HIPPI and its molecular partner HIP-1. Nucleic Acids Research, 38(3), 878-892.
9. Bauernfeind, F., Ablasser, A., Bartok, E., Kim, S., Schmid-Burgk, J., Cavlar, T., et al. (2011). Inflammasomes: Current understanding and open questions. Cellular and Molecular Life Sciences, 68(5), 765-783.
10. Bergmann, A., & Steller, H. (2010). Apoptosis, stem cells, and tissue regeneration. Science Signal, 3(145), re8.
11. Bradford, M. M. (1976). A rapid and sensitive method for the quantization of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
12. Bradstreet, J. J., Smith, S., Baral, M., & Rossignol, D. A. (2010). Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Alternative Medicine Review, 15(1), 15-32.
13. Buttarelli, F. R., Circella, A., Pellicano, C., & Pontieri, F. E. (2006). Dopamine transporter immunoreactivity in peripheral blood mononuclear cells in amyotrophic lateral sclerosis. European Journal of Neurology, 13(4), 416-418.
14. Croonenberghs, J., Bosmans, E., Deboutte, D., Kenis, G., & Maes, M. (2002). Activation of the inflammatory response system in autism. Neuropsychobiology, 45, 1-6. (Pubitemid 34117721)
15. Dai, C., & Krantz, S. B. (1999). Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells. Blood, 93(10), 3309-3316. (Pubitemid 29220898)
16. Denney, D. R., Frei, B. W., & Gaffney, G. R. (1996). Lymphocyte subsets and interleukin-2 receptors in autistic children. Journal of Autism and Developmental Disorders, 26, 87-97. (Pubitemid 126738401)
17. Dickel, H., Gambichler, T., Kamphowe, J., Altmeyer, P., & Skrygan, M. (2010). Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-a and IL-8/ CXCL8 mRNA: New insights into the involvement of 'alarmins'. Contact Dermatitis, 63(4), 215-222.
18. Enstrom, A. M., Onore, C. E., Van de Water, J. A., & Ashwood, P. (2010). Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain, Behavior, and Immunity, 24(1), 64-71.
19. Fang, H. Y., Lin, C. Y., Chow, K. C., Huang, H. C., & Ko, W. J. (2010). Microarray detection of gene overexpression in primary spontaneous pneumothorax. Experimental Lung Research, 36, 323-330.
20. Fujita, E., Dai, H., Tanabe, Y., Zhiling, Y., Yamagata, T., Miyakawa, T., et al. (2010). Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1. Cell Death Disorder, 1(6), e47.
21. Giordano, C., Siniscalco, D., Melisi, D., Luongo, L., Curcio, A., Soukupova, M., et al. (2011). The galactosylation of N(x)-nitro- L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice. European Journal of Pharmacology, 656(1-3), 52-62.
22. Gregg, J. P., Lit, L., Baron, C. A., Hertz-Picciotto, I., Walker, W., Davis, R. A., et al. (2008). Gene expression changes in children with autism. Genomics, 91(1), 22-29. (Pubitemid 350298392)
23. Gupta, S., Samra, D., & Agrawal, S. (2010). Adaptive and innate immune responses in Autism: Rationale for therapeutic use of intravenous immunoglobulin. Journal of Clinical Immunology, 30, S90-S96.
24. Hallmayer, J., Cleveland, S., Torres, A., Phillips, J., Cohen, B., Torigoe, T., et al. (2011). Genetic heritability and shared environmental factors among twin pairs with Autism. Archives of General Psychiatry (in press).
25. Heikaus, S., Pejin, I., Gabbert, H. E., Ramp, U., & Mahotka, C. (2010). PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs. Cell Oncol, 32(1-2), 29-42.
26. Jyonouchi, H., Sun, S., & Le, H. (2001). Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. Journal of Neuroimmunology, 120(1-2), 170-179. (Pubitemid 33016737)
27. Lakshmanan, U., & Porter, A. G. (2007). Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide- induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1). Journal of Immunology, 179(12), 8480-8490.
28. Lamkanfi, M., Festjens, N., Declercq, W., Vanden Berghe, T., & Vandenabeele, P. (2007). Caspases in cell survival, proliferation and differentiation. Cell Death Differentiation, 14, 44-55. (Pubitemid 44911893)
29. Lamkanfi, M., Kanneganti, T. D., Van Damme, P., Vanden Berghe, T., Vanoverberghe, I., Vandekerckhove, J., et al. (2008). Targeted peptide-centric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Molecular Cell Proteomics, 7(12), 2350-2363.
30. Launay, S., Hermine, O., Fontenay, M., Kroemer, G., Solary, E., & Garrido, C. (2005). Vital functions for lethal caspases. Oncogene, 24(33), 5137-5148. (Pubitemid 41192431)
31. Levy, S. E., Mandell, D. S., & Schultz, R. T. (2009). Autism. Lancet, 374(9701), 1627-1638.
32. Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X. M., et al. (2009). Elevated immune response in the brain of autistic patients. Journal of Neuroimmunology, 207(1-2), 111-116.
33. Li, F., He, Z., Shen, J., Huang, Q., Li, W., Liu, X., et al. (2010). Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell & Stem Cell Engineering, 7(4), 508-520.
34. Lisi, S., Sisto, M., Lofrumento, D., Frassanito, M. A., Caprio, S., Romano, M. L., et al. (2010). Regulation of mRNA caspase-8 levels by anti-nuclear autoantibodies. International Journal of Clinical & Experimental Medicine, 10, 199-203.
35. MacKenzie, S. H., Schipper, J. L., & Clark, A. C. (2010). The potential for caspases in drug discovery. Current Opinion in Drug Discovery & Development, 13(5), 568-576.
36. Martinez, J. A., Zhang, Z., Svetlov, S. I., Hayes, R. L., Wang, K. K., & Larner, S. F. (2010). Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis, 15(12), 1480-1493.
37. Martinon, F., & Tschopp, J. (2007). Inflammatory caspases and inflammasomes: Master switches of inflammation. Cell Death and Differentiation, 14(1), 10-22. (Pubitemid 44911890)
38. McComb, S., Mulligan, R., & Sad, S. (2010). Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo. PLoS One, 5(12), e15328.
39. Molloy, C. A., Morrow, A. L., Meinzen-Derr, J., Schleifer, K., Dienger, K., Manning-Courtney, P., et al. (2006). Elevated cytokine levels in children with autism spectrum disorder. Journal of Neuroimmunology, 172(1-2), 198-205. (Pubitemid 43277506)
40. Momoi, T. (2004). Caspases involved in ER stress-mediated cell death. Journal of Chemical Neuroanatomy, 28(1-2), 101-105.
41. Murakami, Y., Aizu-Yokota, E., Sonoda, Y., Ohta, S., & Kasahara, T. (2007). Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of BclxL or Bcl-2. Journal of Biochemistry, 141(3), 401-410. (Pubitemid 46770392)
42. Nakatsumi, H., & Yonehara, S. (2010). Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells. World Journal of Biological Chemistry, 285(33), 25418-25425.
43. Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., et al. (2011). Catalytic activity of the caspase-8- FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature, 471(7338), 363-367.
44. Onore, C., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Van de Water, J., et al. (2009). Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. Journal of Neuroimmunology, 216(1-2), 126-129.
45. Parihar, A., Eubank, T. D., & Doseff, A. I. (2010). Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. Journal of Innate Immunity, 2(3), 204-215.
46. Paulsen, M., Ussat, S., Jakob, M., Scherer, G., Lepenies, I., Schütze, S., et al. (2008). Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes. European Journal of Immunology, 38(7), 1979-1987.
47. Riedl, S. J., Fuentes-Prior, P., Renatus, M., Kairies, N., Krapp, S., Huber, R., et al. (2001). Structural basis for the activation of human procaspase-7. Proceedings of the National Academy of Sciences of the United States of America, 98, 14790-14795. (Pubitemid 34013923)
48. Ruiz-Vela, A., Opferman, J. T., Cheng, E. H., & Korsmeyer, S. J. (2005). Proapoptotic BAX and BAK control multiple initiator caspases. European Molecular Biology Organization Reports, 6(4), 379-385. (Pubitemid 40561632)
49. Salskov-Iversen, M. L., Johansen, C., Kragballe, K., & Iversen, L. (2011). Caspase-5 expression is upregulated in lesional psoriatic skin. Journal of Investigative Dermatology, 131(3), 670-676.
50. Salvesen, G. S., & Riedl, S. J. (2008). Caspase mechanisms. Advances in Experimental Medicine and Biology, 615, 13-23.
51. Schopler, E., Reichler, R. J., & Renner, B. R. (1993). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services.
52. Shi, M., Vivian, C. J., Lee, K. J., Ge, C., Morotomi-Yano, K., Manzl, C., et al. (2009). DNA-PKcs-PIDDosome: a nuclear caspase-2- activating complex with role in G2/M checkpoint maintenance. Cell, 136(3), 508-520.
53. Siniscalco, D., Fuccio, C., Giordano, C., Ferraraccio, F., Palazzo, E., Luongo, L., et al. (2007). Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacological Research, 55(2), 158-166. (Pubitemid 46186043)
54. Siniscalco, D., Giordano, C., Fuccio, C., Luongo, L., Ferraraccio, F., Rossi, F., et al. (2008). Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Pharmacological Research, 57(3), 223-233.
55. Stamova, B. S., Apperson, M., Walker, W. L., Tian, Y., Xu, H., Adamczy, P., et al. (2009). Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Medical Genomics, 2, 49.
56. Stubbs, E. G., & Crawford, M. L. (1977). Depressed lymphocyte responsiveness in autistic children. Journal of Autism and Childhood Schizophrenia, 7, 49-55. (Pubitemid 8081956)
57. Toro, R., Konyukh, M., Delorme, R., Leblond, C., Chaste, P., Fauchereau, F., et al. (2010). Key role for gene dosage and synaptic homeostasis in autism spectrum disorders. Trends in Genetics, 26(8), 363-372.
58. van de Veerdonk, F. L., Netea, M. G., Dinarello, C. A., & Joosten, L. A. (2011). Inflammasome activation and IL-1b and IL-18 processing during infection. Trends Immunology, 32(3), 110-116.
59. Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., et al. (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature, 474(7351), 380-384.
60. Warren, R. P., Margaretten, N. C., Pace, N. C., & Foster, A. (1986). Immune abnormalities in patients with autism. Journal of Autism and Developmental Disorders, 16, 189-197. (Pubitemid 16116775)
61. Williams, K., Wheeler, D. M., Silove, N., & Hazell, P. (2010). Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). The Cochrane Database of Systematic Reviews, 8, CD004677.
62. Yazdi, A. S., Guarda, G., D'Ombrain, M. C., & Drexler, S. K. (2010). Inflammatory caspases in innate immunity and inflammation. Journal of Innate Immunity, 2(3), 228-237.
63. Yi, C. H., & Yuan, J. (2009). The Jekyll and Hyde functions of caspases. Stem Cells and Development, 16(1), 21-34.