Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism;Infecciones por HSV-2 y su relación con anticuerpos antiencéfalo de rata en suero de pacientes con autismo

Investigacion Clinica

Volumn 50, Issue 3, 2009, Pages 315-326

  Mora, Marylú ^a   Quintero, Luis ^b   Cardenas, Ricardo ^b   Suárez Roca, Heberto ^b   Zavala, María ^b   Montiel, Nola ^a,c  

^a Facultad Experimental de Ciencias   (Venezuela)

^b UNIVERSIDAD DEL ZULIA   (Venezuela)

^c FACULTAD DE CIENCIAS VETERINARIAS   (Venezuela)

Author keywords

Autism; Autoimmunity; Neurotrophic virus

Indexed keywords

BRAIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY; ALLOANTIBODY; AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CAUDATE NUCLEUS; CEREBELLUM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; CYTOMEGALOVIRUS; DEVELOPMENTAL DISORDER; DISEASE SEVERITY; EPSTEIN BARR VIRUS; FEMALE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HIPPOCAMPUS; HUMAN; IMMUNOFLUORESCENCE; INFANTILE AUTISM; MALE; MEASLES; NERVE CELL DIFFERENTIATION; NERVOUS TISSUE; NONHUMAN; RAT; RUBELLA; ADOLESCENT; ANIMAL; ANTIBODY SPECIFICITY; AUTISM; BLOOD; BRAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; HERPES VIRUS; IMMUNOLOGY; MEASLES VIRUS; PATHOGENICITY; RUBELLA VIRUS; SPRAGUE DAWLEY RAT;

ADOLESCENT; ANIMALS; ANTIBODIES, VIRAL; AUTISTIC DISORDER; AUTOANTIBODIES; BRAIN; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPES SIMPLEX; HERPESVIRIDAE; HERPESVIRUS 2, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ISOANTIBODIES; MALE; MEASLES VIRUS; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; RUBELLA VIRUS;

EID: 73949115843     PISSN: 05355133     EISSN: 05355133     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Valdez-Miya M. Manual de diagnóstico y estadística de los trastornos mentales. Texto revisado de la Asociación Psiquiátrica Americana. Editores Lopez-Ibor Editorial Masson. 2002; p 79-96.
2. DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C, Schultz RT, Crawley J, Young LJ. The Developmental Neurobiology of Autism Spectrum Disorder. J Neurosci 2006; 26(26): 6897-6906.
3. Joseph RM. Neuropsychological Frameworks for Understanding Autism. Int Rev Psychiatry 1999; 11(4):309-324.
4. Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. J Leukoc Biol 2006; 80:1-15.
5. Singh VK. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav Immunity 1993; 7(1): 97-103.
6. Montiel N. Detección de autoanticuerpos en autismo infantil. Parte I: Anticuerpos Antinucleares. Monografía. [Trabajo de Ascenso]. Maracaibo: Universidad del Zulia; 1997.
7. Singh V, Rivas W. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett 2003; 355:53-56.
8. Silva SC, Correia C, Fesel C, Barreto M, Coutinho AM, Marques C, Miguel TS, Ataide A, Bento C, Borges L, Oliveira G, Vicente AM. Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol 2004; 152(1-2):176-82.
9. Vargas D, Nascimbene C, Krishnan C, Zimmerman A, Pardo C. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005; 57: 67-81.
10. Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci 2007; 1107:92-103.
11. Zimmerman A, Connors S, Matteson K, Lee L, Singer H, Castaneda J and Pearce D. Maternal antibrain antibodies in autism Brain, Behav Immun 2007; 21(3):351-357.
12. Singh VK. Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol 1998; 89(1):105-108.
13. Montiel N. Alteración de los comportamientos humorales y linfocitarios de la respuesta inmunitaria en niños adolescentes con autismo. Monografía. [Trabajo de Ascenso]. Maracaibo: Universidad del Zulia; 2004.
14. Kawashti MI, Amin OR, Rowehy NG. Possible immunological disorders in autism: concomitant autoimmunity and immune tolerance. Egypt J Immunol 2006; 13(1): 99-104.
15. Beers D, Henkel J, Kesner R, Stroop W. Spatial recognition memory deficits without notable CNS pathology in rats following herpes simplex encephalitis. J Neurol Sci 1995; 131(2):119-127.
16. Hornig M, Solbrig M, Horscroft N, Weissenbock H, Lipkin WI. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease Curr Top Microbiol Immunol 2001; 253:157-177.
17. Plata-Salaman CR, Ilyin SE, Gayle D, Romanovitch A, Carbone KM. Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides Brain Res Bull 1999; 49; 441-451.
18. Sauder C, de la Torre JC. Cytokine expression in the rat central nervous system following perinatal Borna disease virus infection. J Neuroimmunol 1999; 96:29-45.
19. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring J Neurosci 2003; 23:297-302.
20. Valero N, Henriquez R, Hernandez C, Pomeda O, Urdaneta F, Atencio R, Larreal Y, Espina L, Rodriguez Z. Agentes virales en pacientes con procesos infecciosos del Sistema Nervioso Central. Invest Clin 2001; 42(4):241-254.
21. Pellegrino L, Pellegrino A, Cushman A. A Stereotaxic Atlas of the Rat Brain. 2a. Edición. New York: Plenum Press; 1981, p 40-90.
22. Cavallero JJ, Palmer DF, Bigazzi PE. Immunofluorescence detection of autoimmune diseases. Immunology Seven NO7. Centers for Disease Control. Atlanta C.A; 1976, p 12-18.
23. Abumohor P. Interpretación del Laboratorio en Reumatología. Reumatología 2005; 21(4):201-205.
24. Pons H. Manual de métodos inmunológicos, Maestría en Biología, Mención Inmunología, Facultad Experimental de Ciencias. Universidad del Zulia.
25. Visauta B. Análisis estadístico con SPSS para Windows. Estadística Básica. Mc Graw Hill; 1998, p 88- 95.
26. Egaas B, Courchesne E, Saitoh O. Reduced size of the corpus callosum in autism. Arch Neurol 1995; 52: 794-801.
27. Aylward EH, Minshew NJ, Goldstein G, Honeycutt NA, Augustine AM, Yates KO. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology 1999; 53:2145-2150.
28. Bauman M, Kemper A. Microscopic neuroanatomic abnormalities in autism. Pediatrics 1991; 87: 791-795.
29. Ramos-Vara JA, Kiupel M, Baszler T, Bliven L, Brodersen B, Chelack B, Czub S, Piero FD, Dial S, Ehrhart EJ, Graham T, Manning L, Paulsen D, Valli VE, West K. Suggested guidelines for immunohisto-chemical techniques in veterinary diagnostic laboratories. J Vet Diagn Invest 2008; 20(4):393-413.
30. Singh VK, Jensen R. Elevated levels of measles antibodies in children with autism. Pediatr Neurol 2003; 28:128-133.
31. Patterson PH. Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr Opin Neurobiol 2002; 12:115-118.