Controlled dual drug release and In Vitro cytotoxicity of electrospun poly(lactic-co-glycolic acid) nanofibers encapsulated with micelles

Journal of Biomedical Nanotechnology

Volumn 11, Issue 3, 2015, Pages 428-435

  Liu, Wanyun ^a,b   Wei, Junchao ^a   Wei, Yen ^c   Chen, Yiwang ^a  

^a NANCHANG UNIVERSITY   (China)

^b YICHUN UNIVERSITY   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

Controlled release; Electrospinning; Micelles; Nanofibers

Indexed keywords

CHEMOTHERAPY; COPOLYMERS; CYTOTOXICITY; DRUG PRODUCTS; ELECTROSPINNING; EMULSIFICATION; HYDROPHOBICITY; MICELLES; POLYETHYLENE GLYCOLS; POLYMER BLENDS; POLYMERS;

COMPOSITE NANOFIBERS; CONTROLLED RELEASE; ELECTROSPUN COMPOSITE; ELECTROSPUN FIBERS; ELECTROSPUN PLGA; POLY(LACTIC-CO-GLYCOLIC ACID); POLYMERIC MICELLE; SUSTAINED RELEASE;

NANOFIBERS;

BREFELDIN A; MONOMETHOXY POLY(ETHYLENE GLYCOL) B POLY(LACTIDE); NANOFIBER; PACLITAXEL; POLYGLACTIN; POLYLACTIDE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; LACTIC ACID; MICELLE; NANOCAPSULE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED DRUG RELEASE; CONTROLLED DUAL DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ELECTROSPINNING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLE; NANOEMULSION; NANOENCAPSULATION; ADMINISTRATION AND DOSAGE; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; ELECTROPLATING INDUSTRY; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; ROTATION; SYNTHESIS; TREATMENT OUTCOME; ULTRASTRUCTURE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREFELDIN A; DELAYED-ACTION PREPARATIONS; DIFFUSION; ELECTROPLATING; HEP G2 CELLS; HUMANS; LACTIC ACID; MICELLES; NANOCAPSULES; NANOFIBERS; NEOPLASMS, EXPERIMENTAL; PACLITAXEL; POLYGLYCOLIC ACID; ROTATION; TREATMENT OUTCOME;

EID: 84918508883     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2015.1827     Document Type: Article

References (32)

1. V. Thavasi, G. Singh, and S. Ramakrishna, Electrospun nanofibers in energy and environmental applications. Energy Environ. Sci. 1, 205 (2008).
2. X. F. Lu, C. Wang, and Y. Wei, One-dimensional composite nanomaterials: Synthesis by electrospinning and their applications. Small 5, 2349 (2009).
3. H. S. Yoo, T. G. Kim, and T. G. Park, Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61, 1033 (2009).
4. C. Meng, Y. Xiao, P. Wang, L. Zhang, Y. X. Liu, and L. M. Tong, Quantum-dot-doped polymer nanofibers for optical sensing. Adv. Mater. 23, 3770 (2011).
5. Y.-F. Goh, I. Shakir, and R. Hussain, Electrospun fibers for tissue engineering, drug delivery, and wound dressing. J. Mater. Sci. 48, 3027 (2013).
6. X. L. Xu, X. S. Chen, X. Y. Xu, T. C. Lu, X. Wang, L. X. Yang, and X. B. Jing, BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells. J. Control. Release 114, 307 (2006).
7. X. L. Xu, X. S. Chen, Z. F. Wang, and X. B. Jing, Ultrafine PEG-PLA fibers loaded with both paclitaxel and doxorubicin hydrochloride and their in vitro cytotoxicity. Eur. J. Pharm. Biopharm. 72, 18 (2009).
8. P. Chen, Q. S. Wu, Y. P. Ding, M. Chu, Z. M. Huang, and W. Hu, A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro. Eur. J. Pharm. Biopharm. 76, 413 (2010).
9. K. N. Kontogiannopoulos, A. N. Assimopoulou, I. Tsivintzelis, C. Panayiotou, and V. P. Papageorgiou, Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications. Int. J. Pharm. 409, 216 (2011).
10. S. T. Yohe, V. L. Herrera, Y. L. Colson, and M. W. Grinstaff, 3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells. J. Control. Release 162, 92 (2012).
11. L. Jin, T. Wang, M. L. Zhu, M. K. Leach, Y. I. Naim, J. M. Corey, Z. Q. Feng, and Q. Jiang, Electrospun fibers and tissue engineering. J. Biomed. Nanotechnol. 8, 1 (2012).
12. C. B. Weldon, J. H. Tsui, S. A. Shankarappa, V. T. Nguyen, M. Ma, D. G. Anderson, and D. S. Kohane, Electrospun drug-eluting sutures for local anesthesia. J. Control. Release 161, 903 (2012).
13. R. A. Thakur, C. A. Florek, J. Kohn, and B. B. Michniak, Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int. J. Pharm. 364, 87 (2008).
14. A. M. Piras, F. Chiellini, E. Chiellini, L. Nikkola, and N. Ashammakhi, New multicomponent bioerodible electrospun nanofibers for dual-controlled drug release. J. Bioact. Compat. Polym. 23, 423 (2008).
15. F. Ahmed, R. I. Pakunlu, A. Brannan, F. Bates, T. Minko, and D. E. Discher, Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116, 150 (2006).
16. A. Jaklenec, A. Hinckfuss, B. Bilgen, D. M. Ciombor, R. Aaron, and E. Mathiowitz, Sequential release of bioactive IGF-I and TGF-1 from PLGA microsphere-based scaffolds. Biomaterials 29, 1518 (2008).
17. Y. Su, X. Q. Li, S. P. Liu, X. M. Mo, and R. Seeram, Controlled release of dual drugs from emulsion electrospun nanofibrous mats. Colloid Surf. B 73, 376 (2009).
18. B. Dong, M. E. Smith, and G. E. Wnek, Encapsulation of multiple biological compounds within a single electrospun fiber. Small 5, 1508 (2009).
19. M. Beck-Broichsitter, M. Thieme, J. Nguyen, T. Schmehl, T. Gessler, W. Seeger, S. Agarwal, A. Greiner, and T. Kissel, Novel 'nano in nano' composites for sustained drug delivery: Biodegradable nanoparticles encapsulated into nanofiber non-wovens. Macromol. Biosci. 10, 1527 (2010).
20. B. T. Song, C. T. Wu, and J. Chang, Dual drug release from electrospun poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles composite mats with distinct release profiles. Acta Biomater. 8, 1901 (2012).
21. E. Jo, S. Lee, K. T. Kim, Y. S. Won, H. S. Kim, E. C. Cho, and U. Jeong, Core-sheath nanofibers containing colloidal arrays in the core for programmable multi-Agent delivery. Adv. Mater. 21, 968 (2009).
22. Y. Z. Wang, W. L. Qiao, B. C. Wang, Y. Q. Zhang, P. Y. Shao, and T. Y. Yin, Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs. Polym. J. 43, 478 (2011).
23. G. M. Kim, A. Wutzler, H. J. Radusch, G. H. Michler, P. Simon, R. A. Sperling, and W. J. Parak, One-dimensional arrangement of gold Nanoparticles by electrospinning. Chem. Mater. 17, 4949 (2005).
24. J. Xu, Y. Jiao, X. Shao, and C. Zhou, Controlled dual release of hydrophobic and hydrophilic drugs from electrospun poly(l-lactic acid) fiber mats loaded with chitosan microspheres. Mater. Lett. 65, 2800 (2011).
25. G. Gaucher, M. H. Dufresne, V. P. Sant, N. Kang, D. Maysinger, and J. C. Leroux, Block copolymer micelles: Preparation, characterization and application in drug delivery. J. Control. Release 109, 169 (2005).
26. D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, and R. Langer, Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2, 751 (2007).
27. V. P. Torchilin, Micellar nanocarriers: Pharmaceutical perspectives. Pharm. Res. 24, 1 (2007).
28. C. Oerlemans, W. Bult, M. Bos, G. Storm, J. F. Nijsen, and W. E. Hennink, Polymeric micelles in anticancer therapy: Targeting, imaging and triggered release. Pharm. Res. 27, 2569 (2010).
29. J. P. Jain and N. Kumar, Self assembly of amphiphilic (PEG)(3)-PLA copolymer as polymersomes: Preparation, characterization, and their evaluation as drug carrier. Biomacromolecules 11, 1027 (2010).
30. W. Y. Liu, J. C. Wei, P. Huo, Y. H. Lu, Y. W. Chen, and Y. Wei, Controlled release of brefeldin A from electrospun PEG-PLLA nanofibers and their in vitro antitumor activity against HepG2 cells. Mater. Sci. Eng. C 33, 2513 (2013).
31. W. Y. Liu, J. C. Wei, P. Huo, Y. H. Lu, Y. W. Chen, and Y. Wei, Synthesis and cytotoxicity of brefeldin A conjugated monomethoxypoly( ethylene glycol)-b-poly(L-lactide) polymeric micelles. J. Biomater. Sci. Polym. Ed. 24, 986 (2013).
32. G. P. Ma, Y. Liu, C. Peng, D. W. Fang, B. J. He, and J. Nie, Paclitaxel loaded electrospun porous nanofibers as mat potential application for chemotherapy against prostate cancer. Carbohydr. Polym. 86, 505 (2011).