Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs

Polymer Journal

Volumn 43, Issue 5, 2011, Pages 478-483

  Wang, Yazhou ^a   Qiao, Weili ^a   Wang, Bochu ^a   Zhang, Yiqiong ^a   Shao, Pengyu ^a   Yin, Tieying ^a  

^a CHONGQING UNIVERSITY   (China)

Author keywords

composite nanofibers; core sheath structure; dual drugs; electrospinning; programmable release

Indexed keywords

COMPOSITE NANOFIBERS; CORE-SHEATH STRUCTURES; DRUG DELIVERY SYSTEM; DUAL DRUGS; ELECTROSPINNING TECHNIQUES; ELECTROSPUN COMPOSITE; ELECTROSPUN NANOFIBERS; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; LASER SCANNING CONFOCAL MICROSCOPY; PREPARATION PROCESS; PROGRAMMABLE RELEASE; RELEASE BEHAVIORS;

CONFOCAL MICROSCOPY; DRUG DELIVERY; DRUG INTERACTIONS; ELECTROSPINNING; FLUORESCENCE MICROSCOPY; MAGNETIC NOZZLES; NANOPARTICLES; SCANNING; SCANNING ELECTRON MICROSCOPY; TISSUE; TISSUE ENGINEERING;

NANOFIBERS;

EID: 79955776159     PISSN: 00323896     EISSN: 13490540     Source Type: Journal    
DOI: 10.1038/pj.2011.11     Document Type: Article

References (31)

1. Wei, M., Kang, B., Sung, C. M. & Mead, J. Core-sheath structure in electrospun nanofibers from polymer blends. Macromol. Mater. Eng. 291, 1307-1314 (2006). (Pubitemid 44892785)
2. Taepaiboon, P., Rungsardthong, U. & Supaphol, P. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents of vitamin A acid and vitamin E. Eur. J. Pharm. Biopharm. 67, 387-397 (2007). (Pubitemid 47225043)
3. Angeles, M., Cheng, H. S. & Velankar, S. S. Emusion electrospinning: composite fibers from drop breakup during electrospinning. Polym. Adv. Technol. 9, 728-733 (2008).
4. Yoo, H. S., Kim, T. G. & Park, T. G. Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliv. Rev. 61, 1033-1042 (2009).
5. Chew, S. Y., Wen, Y., Dzenis, Y. & Leong, K. W. The role of electrospinning in the emerging field of nanomedicine. Curr. Pharm. Des. 12, 4751-4770 (2006). (Pubitemid 44835140)
6. Sill, T. J. & von Recum, H. A. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29, 1989-2006 (2008).
7. Srikar, R., Yarin, A. L., Megaridis, C. M., Bazilevsky, A. V. & Kelley, E. Desorptionlimited mechanism of release from polymer nanofibers. Langmuir 24, 965-974 (2008). (Pubitemid 351270969)
8. Jo, E., Lee, S., Kim, K. T., Won, Y. S., Kim, H. S., Cho, E. C. & Jeong, U. Core-sheath nanofibers containing colloidal arrays in the core for programmable multi-agent delivery. Adv. Mater. 21, 968-972 (2009).
9. Jaklenec, A., Hinckfuss, A., Bilgen, B., Ciombor, D. M., Aaron, R. & Mathiowitz, E. Sequential release of bioactive IGF-I and TGF-b1 from PLGA microsphere-based scaffolds. Biomaterials 29, 1518-1525 (2008).
10. Ahmed, F., Pakunlu, R. I., Brannan, A., Bates, F., Minko, T. & Discher, D. E. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116, 150-158 (2006). (Pubitemid 44868999)
11. Thakura, R. A., Florekb, C. A., Kohnb, J. & Michniak, B. B. Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int. J. Pharm. 364, 87-93 (2008).
12. Su, Y., Li, Q., Liu, S. P., Mo, X. & Seeram, R. Controlled release of dual drugs from emulsion electrospun nanofibrous mats. Colloid Surf. B 73, 376-381 (2009).
13. Dong, B., Smith, M. E. & Wnek, G. E. Encapsulation of multiple biological compounds within a single electrospun fiber. Small 5, 1508-1512 (2009).
14. Qi, L. F., Xu, Z. R., Jiang, X., Hu, C. H. & Zou, X. F. Preparation and antibacterial activity of chitosan nanoparticles. Carbohyd. Res. 339, 2693-2700 (2004). (Pubitemid 39425140)
15. Papadimitriou, S., Bikiaris, D., Avgoustakis, K., Karavas, E. & Georgarakis, M. Chitosan nanoparticles loaded with dorzolamide and pramipexole. Carbohyd. Polym. 73, 44-54 (2008).
16. Zhao, J. Y. & Wu, J. M. Preparation and characterization of the fluorescent chitosan nanoparticle probe. Chin. J. Anal. Chem. 34, 1555-1559 (2006).
17. Zhang, Q. H., Zhen, J., Chang, Z. J., Zhu, M. F., Mo, X. M. & Chen, D. J. Electrospun carbon nanotube composite nanofibres with uniaxially aligned arrays. Nanotechnology 18, 115611 (2007).
18. Shah, S., Pal, A., Kaushik, V. K. & Devi, S. Preparation and characterization of venlafaxine hydrochloride-loaded chitosan nanoparticles and in vitro release of drug. J. Appl. Polym. Sci. 112, 2876-2887 (2009).
19. Li, H. & Gao, C. Y. Preparation and properties of ionically cross-linked chitosan nanoparticles. Polym. Adv. Technol. 20, 613-619 (2009).
20. Qi, H. X., Hu, P., Xu, J. & Wang, A. J. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules 7, 2327-2330 (2006). (Pubitemid 44336343)
21. Saeed, K., Park, S. Y., Lee, H. J., Baek, J. B. & Huh, W. S. Preparation of electrospun nanofibers of carbon nanotube/polycaprolactone nanocomposite. Polymer 47, 8019-8025 (2006). (Pubitemid 44740024)
22. Shao, C. L., Kim, H. Y., Gong, J., Ding, B., Lee, D. R. & Park, S. J. Fiber mats of poly(vinyl alcohol)/silica composite via electrospinning. Mater. Lett. 57, 1579-1584 (2003).
23. Teo, W. E. & Ramakrishna, S. Electrospun nanofibers as a platform for multifunctional, hierarchically organized nanocomposite. Comp. Sci. Technol. 69, 1804-1817 (2009).
24. Xu, X. L., Chen, X. S., Liu, A. X., Hong, Z. K. & Jing, X. B. Electrospun poly(L-lactide)- grafted hydroxyapatite/poly(L-lactide) nanocomposite fibers. Eur. Polym. J. 43, 3187-3196 (2007).
25. Xu, X. L., Chen, X. S., Ma, P. A., Wang, X. R. & Jing, X. B. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur. J. Pharm. Biopharm. 70, 165-170 (2008).
26. Lim, J. M., Moon, J. H., Yi, G. R., Heo, C. J. & Yang, S. M. Fabrication of one-dimensional colloidal assemblies from electrospun nanofibers. Langmuir 22, 3345-3349 (2006).
27. Tungprapa, S., Jangchud, I. & Supaphol, P. Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats. Polymer 48, 5030-5041 (2007). (Pubitemid 47176059)
28. Gandhi, M., Srikar, R., Yarin, A. L., Megaridis, C. M. & Gemeinhart, R. A. Mechanistic examination of protein release from polymer nanofibers. Mol. Pharm. 6, 641-647 (2009).
29. Hughes, G. A. Nanostructure-mediated drug delivery. Nanomedicine 1, 22-30 (2005). (Pubitemid 43963612)
30. Taepaiboon, P., Rungsardthong, U. & Supaphol, P. Drug-loaded electrospun mats of poly(vinyl alcohol) fibers and their release characteristics of four model drugs. Nanotechnology 17, 2317-2329 (2006).
31. Zeng, J., Yang, L. X., Liang, Q. Z., Zhang, X. F., Guan, H. L., Xu, X. L., Chen, X. S. & Jing, X. B. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J. Control Release 105, 43-51 (2005). (Pubitemid 40805474)