Effect of urinary protease inhibitor (ulinastatin) on cardiopulmonary bypass: A meta-analysis for China and Japan

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Zhang, Yun ^a   Zeng, Zhi ^a   Cao, Yu ^a   Du, Xiaodong ^a   Wan, Zhi ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; CREATINE KINASE MB; INOTROPIC AGENT; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN; GLYCOPROTEIN; TRYPSIN INHIBITOR;

ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY BYPASS; CHINA; CLINICAL EFFECTIVENESS; DRUG EFFICACY; DRUG USE; HEART HEMODYNAMICS; HEART MUSCLE INJURY; HUMAN; INTENSIVE CARE UNIT; INTUBATION; JAPAN; LENGTH OF STAY; MEAN ARTERIAL PRESSURE; META ANALYSIS; OPEN HEART SURGERY; PERIOPERATIVE PERIOD; POSTOPERATIVE HEMORRHAGE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT PLANNING; PROCEDURES; TREATMENT OUTCOME; URINE;

CARDIOPULMONARY BYPASS; CHINA; GLYCOPROTEINS; HUMANS; JAPAN; TREATMENT OUTCOME; TRYPSIN INHIBITORS;

EID: 84917706589     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0113973     Document Type: Article

References (80)

1. Butler J, Rocker GM, Westaby S (1993) Inflammatory response to cardiopulmonary bypass. The Annals of thoracic surgery 55: 552-559.
2. Laffey JG, Boylan JF, Cheng DC (2002) The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology 97: 215-252.
3. Sablotzki A, Friedrich I, Muhling J, Dehne MG, Spillner J, et al. (2002) The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines, procalcitonin in patients with and without multiorgan dysfunctions. Perfusion 17: 103-109.
4. Song J, Park J, Kim JY, Kim JD, Kang WS, et al. (2013) Effect of ulinastatin on perioperative organ function and systemic inflammatory reaction during cardiac surgery: a randomized double-blinded study. Korean J Anesthesiol 64: 334-340.
5. Wang GY, Qiu HB, Zhan SG, Li LH (2007) [Protection of ulinastatin against myocardial injury induced by off-pump coronary artery bypass graft surgery: report of 24 cases]. Zhonghua yi xue za zhi 87: 2502-2504.
6. Chen H, He MY, Li YM (2009) Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study. Chinese medical journal 122: 883-888.
7. Kanai T, Ishiwata T, Kobayashi T, Sato H, Takizawa M, et al. (2011) Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study. Circulation 124: 2822-2828.
8. Xu CE, Zou CW, Zhang MY, Guo L (2013) Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest. Journal of cardiothoracic and vascular anesthesia 27: 479-484.
9. Park JB, Kim SH, Lee SA, Chung JW, Kim JS, et al. (2013) Effects of ulinastatin on postoperative blood loss and hemostasis in atrioventricular valve surgery with cardiopulmonary bypass. The Korean journal of thoracic and cardiovascular surgery 46: 185-191.
10. Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC medical research methodology 5: 13.
11. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, et al. (2011) The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Bmj 343: d5928.
12. Song JE, Kang WS, Kim DK, Yoon TG, Kim TY, et al. (2011) The effect of ulinastatin on postoperative blood loss in patients undergoing open heart surgery with cardiopulmonary bypass. The Journal of international medical research 39: 1201-1210.
13. Oh SY, Kim JC, Choi YS, Lee WK, Lee YK, et al. (2012) Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass. Korean journal of anesthesiology 62: 148-153.
14. Nakanishi K, Takeda S, Sakamoto A, Kitamura A (2006) Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction. Critical care medicine 34: 1351-1357.
15. Chen TT, Jiandong L, Wang G, Jiang SL, Li LB, et al. (2013) Combined treatment of ulinastatin and tranexamic acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery. The heart surgery forum 16: E38-47.
16. Bingyang J, Jinping L, Mingzheng L, Guyan W, Zhengyi F (2007) Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response. The Journal of cardiovascular surgery 48: 497-503.
17. Chen BJ, Sun M, Shao J, Wang DJ (2011) Direct perfusion with hypothermic oxygenated blood mixed with ulinastatin through pulmonary artery to protect pulmonary function during cardiopulmonary bypass. The Journal of Practical Medicine 27: 1765-1767.
18. Chen P, Zhang XH, Chen WD, Luo ZC, Zhou CB, et al. (2003) Effects of ulinastatin on myocardial protection in patients undergoing cardiac operation with cardiopulmonary bypass. Guangdong Medical Journal 24: 281-283.
19. Gao XG (2012) Protective Effect of Ulinastatin on Myocardium in Cardiopulmonary Bypass Surgery. Guide of China Medicine 10: 75-76.
20. Ji HW, Chen L (2009) [Effects of ulinastatin on coagulation and platelet function in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass]. Zhonghua yi xue za zhi 89: 175-178.
21. Jiang B, Jin ZX, Yi W, Ren C, Bai L, et al. (2012) The myocardial and blood protective effects of ulinastatin combined with tranexamic acid in patients underwent valve replacement surgery with cardiopulmonary bypass. Chinese Journal of Extracorporeal Circulation 10: 207-211.
22. Li J, Pan JH, Kang F, Chen KZ (2010) Effects of penehyclidine hydrochloride combined with ulinastatin on lung injury in patients undergoing cardiac valve replacement with cardiopulmonary bypass. Chinese Journal of Anesthesiology 30: 1420-1423.
23. Li LW, Li L, Shen JM, He XJ, Zhou JM (2004) The Protective Effect of Ulinastatin on Myocardial Reperfusion Injury during Cardiopulmonary Bypass in Patients Underwent Valve Replacement. Journal of Chinese Physician 6: 1642-1643.
24. Li Q, Liu Y, Liu S, Yu D, Chen ZY (2012) The protective effect of ulinastatin on lung and kidney for patients with mitral valve replacement. Chinese Journal of Experimental Surgery 29: 1184-1186.
25. Meng DM, Yu JG, Zhou GL, Suai XJ, Lei WF, et al. (2002) Myocardial protective effect of ulinastatin during open heart surgery with cardiopulmonary bypass. Chinese Journal of Anesthesiology 22: 344-347.
26. Qi XY, Hu QF, Huang WQ (2010) Myocardial Protection of Ulinastatin in Patients undergoing Coronary Artery bypass Grafting with Cardiopulmonary Bypass. Herald of Medicine 29: 477-479.
27. Sun CY (2003) Effects of ulinastatin with different doses on myocardial protection for cardiac surgery with cardiopulmonary bypass. Anesthesiology. Jilan: Sandong University. pp.38.
28. Wang X, Yin LJ, Zhang SL (2012) Myocardial Protection of Ulinastatin in Cardiopulmonary Bypass in Patients. The Journal of Medical Theory and Practice 25: 1808-1809.
29. Wang YQ, Chen YX (2008) Protective effect of ulinastatin on lung injury induced by cardiopulmonary bypass. Shaanxi Medical Journal 37: 1620-1622.
30. Xu KQ, Shun PW, Huang WQ, Chen BX, Tan JF, et al. (2004) Effects of ulinastatin on lung function after cardiopulmonary bypass. Chinese Journal of Thoracic and Cardiovascular Surgery 20: 7-9.
31. Zhang JW, Chen Y, Zhu M, Gu HB (2004) Lung protection of different dosages of ulinastatin in infant heart operation under cardiopulmonary bypass. Academic Journal of Shanghai Second Medical University 22: 933-935.
32. Zhou Q, Wang G, Gao CQ, Chen TT (2010) Effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting with cardiopulmonary bypass. Journal of Central South University(Medical Science) 35: 107-110.
33. Jiang YF, Wang WW, Ye Wl, Ni YF, Li J, et al. (2008) Effects of alprostadil and ulinastatin on Inflammatory response and lung injury after cardiopulmonary bypass in pediatric patients with congenital heart diseases. National Medical Journal of Chian 88: 2893-2897.
34. Jiang CB, Cheng DZ, He ZF, Liu Y, Jiang XF, et al. (2009) Effect of ulinastatin on plasma tumor necrosis factor-alpha and A-aDO2 in patients undergoing mitral valve and aortic valve replacement under cardiopulmonary bypass. The Journal of Practical Medicine 25: 1860-1862.
35. Ren BH, Jing H, Li DM, Li ZD (2004) The protective effect of ulinastatin on pulmonary function during cardiopulmonary bypass. Journal of Medical Postgraduates 17: 519-524.
36. Li WD (2009) Effect of Ulinastatin on Inflammatory Response and Renal Function in Pediatric Cardiopulmonary Bypass Surgery. Journal of Clinical Research 26: 1014-1016.
37. Chen RW, Gao JP, Liu PB, Zhou WW, Wang JH (2007) The combined effects of amphylline and ulinastatin to inflammatory cytokines in infants undergoing cardiac operation under cardiopulmonary bypass. Journal of Clinical Pediatric Surgery 6.
38. Li YC, Jiang Z, Jin XH, Luo J, Guo KF (2004) Protective effect of ulinustatin on pulmonary function during cardiopulmonary bypass. Journal of Clinical Anesthesiology 20: 69-72.
39. Chen Y, Zhang JW, Zhou H, Bai J (2005) Application of ulinastatin during open-heart surgery under cardiopulmonary bypass in infants. Journal of Clinical Anesthesiology 21: 527-530.
40. Zou DQ, Zhou JM, Chang YT, He XJ, Yuan GX, et al. (2005) Effects of ulinastatin on cerebral inflammatory response during cardiopulmonary bypass. Journal of Central South University(Medical Science) 30: 420-423.
41. Wang DJ, Liu JX, Yin BL (2005) Protective effects of ulinastatin on lung injury during cardiopulmonary bypass. Journal of Central South University(Medical Science) 30: 670-672.
42. Sugita T, Watarida S, Katsuyama K, Nakajima Y, Yamamoto R, et al. (2002) Effect of a human urinary protease inhibitor (Ulinastatin) on respiratory function in pediatric patients undergoing cardiopulmonary bypass. The Journal of cardiovascular surgery 43: 437-440.
43. Hiyama A, Takeda J, Kotake Y, Morisaki H, Fukushima K (1997) A human urinary protease inhibitor (ulinastatin) inhibits neutrophil extracellular release of elastase during cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia 11: 580-584.
44. Zhong JY, Li JL, Yang CX (2007) Effects of ulinastatin on renal function cardiopulmonary bypass in patients undergoing valve replacement. International Journal of Anesthesiology and Resuscitation 28: 32-34.
45. Li MR, BL L, Zhang XY, Zhan H (2005) Effects of ulinastatin on systemic inflammatory response during cardiopulmonary bypass. Chinese Journal of Primary Medicine and Pharmacy 12: 1157-1158.
46. Qiang Z, Zhou PJ, Li YL, Li TC, Chen CH (2004) Effects of ulinastatin on inflammatory factors during cardiopulmonary bypass. Chinese Journal of Postgraduates of Medicine 27: 24-28.
47. Wei L, Liu B, Liang YN, Chen YJ, Chen H, et al. (2009) The Protective Effects of Ulinastatin on Pulmonary Tissue during Cardiopulmonary Bypass. Chinese Journal of Extracorporeal Circulation 7: 4-7.
48. Liu JD, Wang G, Chen TT, Zhou Q, Gao CQ, et al. (2009) Effects of Ulinastatin on Inflammatory Response to Cardiopulmonary Bypass in Cardiac Valve Replacement Surgery. Chinese Journal of Extracorporeal Circulation 7: 12-15.
49. Li JL, Zhao YL, Li XL, Zhao ZY, Liu XM, et al. (2009) Effects of Ulinastatin on NF -kB Activity of Polymorphonuclear Neutrophils, TNF-a and IL-8 in Patients Undergoing Cardiopulmonary Bypass. Chinese Journal of Extracorporeal Circulation 7: 8-11.
50. Zhang XL, Wang Y, Zhou HY, YAO YY, Ye HZ, et al. (2007) Effect of ulinastatin on expression of S100b protein and TNF-α in patients undergoing open-heart surgery with cardiopulmonary bypass. Chinese Journal of Emergency Medicine 16: 50-53.
51. Shu Q, Yang XW, Shi Z, Shi SS, Zhang XH, et al. (2005) Protective effects of ulinastatin on lung injury in pediatric patients undergoing cardiopulmonary bypass. Chinese Journal of Emergency Medicine 14: 1027-1030.
52. Bao HJ, Gao BS, Li TC, Zhu B, Liu DB, et al. (2006) Protective Effects of Ulinastatin on Liver in Cardiopuimonary Bypass during Open Heart Surgery. Chinese Journal of Clinical Medicine 13: 320-321.
53. Shao B, Hu LD, Guo X, Liu QX, Xia X, et al. (2006) Effects of ulinastatin on proinfiammatory cytokines in mitral valve replacement patients under hypothermic cardiopulmonary bypass. Chinese Journal of Cardiovascular Research 4: 120-122.
54. Zhao Y, Peng J, Yu HL, Kong H, Shi LJ, et al. (2009) Effects of ulinastattn on systemic inflammatory response in patients undergoing cardiac valve replacement with cardiopulmonary bypass. Chinese Journal of Anesthesiology 29: 685-687.
55. Zhao QF, Hu XT, Du J, Wu GW (2007) Effects of ulinastatin and aprotinin on inflammatory response and myocardial injury in children undergoing cardiopulmonary bypass. Chinese Journal of Anesthesiology 27: 199-203.
56. Xu KQ, Chen BX, Huang WQ, Xia HJ, Hei ZQ, et al. (2002) Effects of ulinastatln On lung inflammatory response to cardiopulmonary bypass. Chinese Journal of Anesthesiology 22: 325-328.
57. Yu XY, Fan LL (2009) Effects of different doses of ulinastatin on inflammatory response and pulmonary function after cardiopulmonary bypass. Chinese Critical Care Medicine 21: 664-666.
58. Xue QH, Chang KQ, Cheng WP (2006) Effects of Ulinastatin on Inflammatory Cytokins Levels in Bronchoalveolar Lavage Fluid and Pulmonary Function in Patients Undergoing Cardiopulmonary Bypass. Chinese Circulation Journal 21: 297-300.
59. Kuang X, Huang Y (2004) Influence of ulinastatin of the release of concentration of TNF-a, IL-6 and IL-8 levels in plasma after cardiopulmonary bypass. China Medical Engineering 12: 26-28.
60. Liu Y, Chen JH, Li YQ, Guo QL (2005) Effect of ulinastatin on cerebral inflammatory response in patients undergoing cardiopulmonary bypass. China Journal of Modern Medicine 15: 1389-1391.
61. Kawamura T, Inada K, Akasaka N, Wakusawa R (1996) Ulinastatin reduces elevation of cytokines and soluble adhesion molecules during cardiac surgery. Canadian journal of anaesthesia 5 Journal canadien d'anesthesie 43: 456-460.
62. Talwani R, Heil EL, Gilliam BL, Temesgen Z (2013) Simeprevir: a macrocyclic HCV protease inhibitor. Drugs of today 49: 769-779.
63. Ucciferri C, Falasca K, Vignale F, Di Nicola M, Pizzigallo E, et al. (2013) Improved metabolic profile after switch to darunavir/ritonavir in HIV positive patients previously on protease inhibitor therapy. Journal of medical virology 85: 755-759.
64. Zhirnov OP, Matrosovich TY, Matrosovich MN, Klenk HD (2011) Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus. Antiviral chemistry & chemotherapy 21: 169-174.
65. Morjen M, Kallech-Ziri O, Bazaa A, Othman H, Mabrouk K, et al. (2013) PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells. Matrix biology: journal of the International Society for Matrix Biology 32: 52-62.
66. Sierko E, Wojtukiewicz MZ, Zimnoch L, Ostrowska-Cichocka K, Tokajuk P, et al. (2012) Protein Z/protein Z-dependent protease inhibitor system in human non-small-cell lung cancer tissue. Thrombosis research 129: e92-96.
67. de Almeida Nogueira NP, Morgado-Diaz JA, Menna-Barreto RF, Paes MC and da Silva-Lopez RE (2013) Effects of a marine serine protease inhibitor on viability and morphology of Trypanosoma cruzi, the agent of Chagas disease. Acta tropica 128: 27-35.
68. Matsuno YK, Nakamura H, Kakehi K (2006) Comparative studies on the analysis of urinary trypsin inhibitor (ulinastatin) preparations. Electrophoresis 27: 2486-2494.
69. Chen X, Wang Y, Luo H, Luo Z, Liu L, et al. (2013) Ulinastatin reduces urinary sepsisrelated inflammation by upregulating IL10 and downregulating TNFalpha levels. Molecular medicine reports 8: 29-34.
70. Hu CL, Xia JM, Cai J, Li X, Liao XX, et al. (2013) Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation. Clinics 68: 1231-1238.
71. Li M, Yong-Zhe L, Ya-Qun M, Sheng-Suo Z, Li-Tao Z, et al. (2013) Ulinastatin alleviates neuroinflammation but fails to improve cognitive function in aged rats following partial hepatectomy. Neurochemical research 38: 1070-1077.
72. Daryapeyma A, Aarstad HJ, Wahlgren CM, Jonung T (2014) Perioperative cytokine response to infection associated with elective arterial surgery. Vascular and endovascular surgery 48: 116-122.
73. Hu CL, Li H, Xia JM, Li X, Zeng X, et al. (2013) Ulinastatin improved cardiac dysfunction after cardiac arrest in New Zealand rabbits. The American journal of emergency medicine 31: 768-774.
74. Chen SQ, Zhou SF, Li ZP, Zhang J, Yan P, et al. (2008) [Protective effect of ulinastatin on myocardium after cardiopulmonary resuscitation in rats]. Zhongguo wei zhong bing ji jiu yi xue 5 Chinese critical care medicine 5 Zhongguo weizhongbing jijiuyixue 20: 730-732.
75. Emrich F, Walther T, Muth P, Ullmann C, Rastan AJ, et al. (2012) Selective cerebral perfusion using moderate flow in complex cardiac surgery provides sufficient neuroprotection. Are children young adults? European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery 42: 704-710.
76. Meldrum DR, Donnahoo KK (1999) Role of TNF in mediating renal insufficiency following cardiac surgery: evidence of a postbypass cardiorenal syndrome. The Journal of surgical research 85: 185-199.
77. He QL, Zhong F, Ye F, Wei M, Liu WF, et al. (2014) Does intraoperative ulinastatin improve postoperative clinical outcomes in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials. BioMed research international 2014: 630835.
78. Sirlak M, Eryilmaz S, Yazicioglu L, Kiziltepe U, Inan MB, et al. (2003) Conduction disturbances in coronary artery bypass surgery. International journal of cardiology 92: 43-48.
79. Itaba S, Nakamura K, Aso A, Tokunaga S, Akiho H, et al. (2013) Prospective, randomized, doubleblind, placebo-controlled trial of ulinastatin for prevention of hyperenzymemia after double balloon endoscopy via the antegrade approach. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society 25: 421-427.
80. Zhou Q, Wang G, Gao C, Chen T (2010) [Effect of ulinastatin on perioperative inflammatory response to coronary artery bypass grafting with cardiopulmonary bypass]. Zhong nan da xue xue bao Yi xue ban 5 Journal of Central South University Medical sciences 35: 107-110.