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Volumn 16, Issue 1, 2013, Pages

Combined treatment of ulinastatin and tranexamic acid provides beneficial effects by inhibiting inflammatory and fibrinolytic response in patients undergoing heart valve replacement surgery

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ANTIPLASMIN; BLOOD CLOTTING FACTOR 7; D DIMER; INTERLEUKIN 6; LEUKOCYTE ELASTASE; OXYGEN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN; VASOACTIVE AGENT;

EID: 84876267135     PISSN: 10983511     EISSN: 15226662     Source Type: Journal    
DOI: 10.1532/HSF98.20121072     Document Type: Article
Times cited : (22)

References (35)
  • 1
    • 0032210412 scopus 로고    scopus 로고
    • Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating tnf-alpha in the liver
    • Aihara T, Shiraishi M, Hiroyasu S, et al. 1998. Ulinastatin, a protease inhibitor, attenuates hepatic ischemia/reperfusion injury by downregulating TNF-alpha in the liver. Transplant Proc 30:3732-4.
    • (1998) Transplant Proc , vol.30 , pp. 3732-3734
    • Aihara, T.1    Shiraishi, M.2    Hiroyasu, S.3
  • 2
    • 0035259695 scopus 로고    scopus 로고
    • Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes
    • Aosasa S, Ono S, Mochizuki H, Tsujimoto H, Ueno C, Matsumoto A. 2001. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock 15:101-5.
    • (2001) Shock , vol.15 , pp. 101-105
    • Aosasa, S.1    Ono, S.2    Mochizuki, H.3    Tsujimoto, H.4    Ueno, C.5    Matsumoto, A.6
  • 3
    • 35848933466 scopus 로고    scopus 로고
    • Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response
    • Bingyang J, Jinping L, Mingzheng L, Guyan W, Zhengyi F. 2007. Effects of urinary protease inhibitor on inflammatory response during on-pump coronary revascularisation. Effect of ulinastatin on inflammatory response. J Cardiovasc Surg 48:497-503.
    • (2007) J Cardiovasc Surg , vol.48 , pp. 497-503
    • Bingyang, J.1    Jinping, L.2    Mingzheng, L.3    Guyan, W.4    Zhengyi, F.5
  • 4
    • 0034017155 scopus 로고    scopus 로고
    • Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart
    • Cao ZL, Okazaki Y, Naito K, Ueno T, Natsuaki M, Itoh T. 2000. Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart. Ann Thorac Surg 69:1121-6.
    • (2000) Ann Thorac Surg , vol.69 , pp. 1121-1126
    • Cao, Z.L.1    Okazaki, Y.2    Naito, K.3    Ueno, T.4    Natsuaki, M.5    Itoh, T.6
  • 5
    • 0028783341 scopus 로고
    • Individual variations in the fibrinolytic response during and after cardiopulmonary bypass
    • Chandler WL, Fitch JC, Wall MH, et al. 1995. Individual variations in the fibrinolytic response during and after cardiopulmonary bypass. Thromb Haemost 74:1293-7.
    • (1995) Thromb Haemost , vol.74 , pp. 1293-1297
    • Chandler, W.L.1    Fitch, J.C.2    Wall, M.H.3
  • 6
    • 5644295330 scopus 로고    scopus 로고
    • Plasmin generation and d-dimer formation during cardiopulmonary bypass
    • Chandler WL, Velan T. 2004. Plasmin generation and D-dimer formation during cardiopulmonary bypass. Blood Coagul Fibrinolysis 15: 583-91.
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 583-591
    • Chandler, W.L.1    Velan, T.2
  • 7
    • 0035163406 scopus 로고    scopus 로고
    • Mechanisms and attenuation of hemostatic activation during extracorporeal circulation
    • Despotis GJ, Avidan MS, Hogue CW Jr. 2001. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg 72:S1821-31.
    • (2001) Ann Thorac Surg , vol.72
    • Despotis, G.J.1    Avidan, M.S.2    Hogue Jr., C.W.3
  • 8
    • 0027443456 scopus 로고
    • The inhibitory actions of protease inhibitors on the production of polymorphonuclear leukocyte elastase and interleukin 8
    • Endo S, Inada K, Yamashita H, et al. 1993. The inhibitory actions of protease inhibitors on the production of polymorphonuclear leukocyte elastase and interleukin 8. Res Commun Chem Pathol Pharmacol 82:27-34.
    • (1993) Res Commun Chem Pathol Pharmacol , vol.82 , pp. 27-34
    • Endo, S.1    Inada, K.2    Yamashita, H.3
  • 9
    • 0038676410 scopus 로고    scopus 로고
    • Myocardial and lung injury after cardiopulmonary bypass: Role of interleukin (il)-10
    • Giomarelli P, Scolletta S, Borrelli E, Biagioli B. 2003. Myocardial and lung injury after cardiopulmonary bypass: role of interleukin (IL)-10. Ann Thorac Surg 76:117-23.
    • (2003) Ann Thorac Surg , vol.76 , pp. 117-123
    • Giomarelli, P.1    Scolletta, S.2    Borrelli, E.3    Biagioli, B.4
  • 10
    • 0345356441 scopus 로고    scopus 로고
    • Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: A randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin
    • Greilich PE, Brouse CF, Whitten CW, Chi L, Dimaio JM, Jessen ME. 2003. Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin. J Thorac Cardiovasc Surg 126:1498-503.
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 1498-1503
    • Greilich, P.E.1    Brouse, C.F.2    Whitten, C.W.3    Chi, L.4    Dimaio, J.M.5    Jessen, M.E.6
  • 11
    • 0036118881 scopus 로고    scopus 로고
    • Hemorrhage related reexploration following open heart surgery: The impact of pre-operative and post-operative coagulation testing
    • Hall TS, Sines JC, Spotnitz AJ. 2002. Hemorrhage related reexploration following open heart surgery: the impact of pre-operative and post-operative coagulation testing. Cardiovasc Surg 10:146-53.
    • (2002) Cardiovasc Surg , vol.10 , pp. 146-153
    • Hall, T.S.1    Sines, J.C.2    Spotnitz, A.J.3
  • 12
    • 0026052991 scopus 로고
    • The effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation
    • Havel M, Teufelsbauer H, Knöbl P, et al. 1991. The effect of intraoperative aprotinin administration on postoperative bleeding in patients undergoing cardiopulmonary bypass operation. J Thorac Cardiovasc Surg 101:968-72.
    • (1991) J Thorac Cardiovasc Surg , vol.101 , pp. 968-972
    • Havel, M.1    Teufelsbauer, H.2    Knöbl, P.3
  • 13
    • 0031877808 scopus 로고    scopus 로고
    • Human neutrophil elastase degrades inter-alpha-trypsin inhibitor to liberate urinary trypsin inhibi tor related proteins
    • Hirose J, Ozawa T, Miura T, et al. 1998. Human neutrophil elastase degrades inter-alpha-trypsin inhibitor to liberate urinary trypsin inhibitor related proteins. Biol Pharm Bull 21:651-6.
    • (1998) Biol Pharm Bull , vol.21 , pp. 651-656
    • Hirose, J.1    Ozawa, T.2    Miura, T.3
  • 15
    • 34248330831 scopus 로고    scopus 로고
    • Factors associated with excessive bleeding in cardiopulmonary bypass patients: A nested case-control study
    • Jimenez Rivera JJ, Iribarren JL, Raya JM, et al. 2007. Factors associated with excessive bleeding in cardiopulmonary bypass patients: a nested case-control study. J Cardiothorac Surg 2:17.
    • (2007) J Cardiothorac Surg , vol.2 , pp. 17
    • Jimenez Rivera, J.J.1    Iribarren, J.L.2    Raya, J.M.3
  • 16
    • 74049141396 scopus 로고    scopus 로고
    • The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery
    • Karkouti K, Wijeysundera DN, Yau TM, et al. 2010. The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery. Anesth Analg 110:21-9.
    • (2010) Anesth Analg , vol.110 , pp. 21-29
    • Karkouti, K.1    Wijeysundera, D.N.2    Yau, T.M.3
  • 17
    • 4844227317 scopus 로고    scopus 로고
    • The independent association of massive blood loss with mortality in cardiac surgery
    • Karkouti K, Wijeysundera DN, Yau TM, et al. 2004. The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 44:1453-62.
    • (2004) Transfusion , vol.44 , pp. 1453-1462
    • Karkouti, K.1    Wijeysundera, D.N.2    Yau, T.M.3
  • 18
    • 0026445611 scopus 로고
    • Fibrinolysis and extracorporeal circulation
    • Kluft C. 1992. Fibrinolysis and extracorporeal circulation. Agents Actions Suppl 38:305-9.
    • (1992) Agents Actions Suppl , vol.38 , pp. 305-309
    • Kluft, C.1
  • 19
    • 33646845605 scopus 로고    scopus 로고
    • Transfusion in coronary artery bypass grafting is associated with reduced long-term survival
    • Koch CG, Li L, Duncan AI, et al. 2006. Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg 81:1650-7.
    • (2006) Ann Thorac Surg , vol.81 , pp. 1650-1657
    • Koch, C.G.1    Li, L.2    Duncan, A.I.3
  • 20
    • 1542751780 scopus 로고    scopus 로고
    • Urinary trypsin inhibitor improves peripheral microcirculation and bronchospasm associated with systemic anaphylaxis in rabbits in vivo
    • Komori M, Takada K, Tomizawa Y, Uezono S, Ozaki M. 2003. Urinary trypsin inhibitor improves peripheral microcirculation and bronchospasm associated with systemic anaphylaxis in rabbits in vivo. Shock 20:189-94.
    • (2003) Shock , vol.20 , pp. 189-194
    • Komori, M.1    Takada, K.2    Tomizawa, Y.3    Uezono, S.4    Ozaki, M.5
  • 21
    • 25444501562 scopus 로고    scopus 로고
    • The effects of aprotinin and tranexamic acid on thrombin generation and fibrinolytic response after cardiac surgery
    • Kuitunen A, Hiippala S, Vahtera E, Rasi V, Salmenperä M. 2005. The effects of aprotinin and tranexamic acid on thrombin generation and fibrinolytic response after cardiac surgery. Acta Anaesthesiol Scand 49:1272-9.
    • (2005) Acta Anaesthesiol Scand , vol.49 , pp. 1272-1279
    • Kuitunen, A.1    Hiippala, S.2    Vahtera, E.3    Rasi, V.4    Salmenperä, M.5
  • 22
    • 0037710254 scopus 로고    scopus 로고
    • Risk factors for sternal wound infection and mid-term survival following coronary artery bypass surgery
    • Lu JC, Grayson AD, Jha P, Srinivasan AK, Fabri BM. 2003. Risk factors for sternal wound infection and mid-term survival following coronary artery bypass surgery. Eur J Cardiothorac Surg 23:943-9.
    • (2003) Eur J Cardiothorac Surg , vol.23 , pp. 943-949
    • Lu, J.C.1    Grayson, A.D.2    Jha, P.3    Srinivasan, A.K.4    Fabri, B.M.5
  • 23
    • 0035125613 scopus 로고    scopus 로고
    • Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass
    • Massoudy P, Zahler S, Becker BF, Braun SL, Barankay A, Meisner H. 2001. Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass. Chest 119:31-6.
    • (2001) Chest , vol.119 , pp. 31-36
    • Massoudy, P.1    Zahler, S.2    Becker, B.F.3    Braun, S.L.4    Barankay, A.5    Meisner, H.6
  • 24
    • 0033547701 scopus 로고    scopus 로고
    • Is epsilon-aminocaproic acid as effective as apotinin in reducing bleeding with cardiac surgery? A meta-analysis
    • Munoz JJ, Birkmeyer NJ, Birkmeyer JD, O'Connor GT, Dacey LJ. 1999. Is epsilon-aminocaproic acid as effective as apotinin in reducing bleeding with cardiac surgery? A meta-analysis. Circulation 99:81-9.
    • (1999) Circulation , vol.99 , pp. 81-89
    • Munoz, J.J.1    Birkmeyer, N.J.2    Birkmeyer, J.D.3    O'Connor, G.T.4    Dacey, L.J.5
  • 25
    • 0029967903 scopus 로고    scopus 로고
    • Ulinastatin ameliorates acute ischemic renal injury in rats
    • Nakahama H, Obata K, Sugita M. 1996. Ulinastatin ameliorates acute ischemic renal injury in rats. Ren Fail 18:893-8.
    • (1996) Ren Fail , vol.18 , pp. 893-898
    • Nakahama, H.1    Obata, K.2    Sugita, M.3
  • 26
    • 33646591214 scopus 로고    scopus 로고
    • Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction
    • Nakanishi K, Takeda S, Sakamoto A, Kitamura A. 2006. Effects of ulinastatin treatment on the cardiopulmonary bypass-induced hemodynamic instability and pulmonary dysfunction. Crit Care Med 34:1351-7.
    • (2006) Crit Care Med , vol.34 , pp. 1351-1357
    • Nakanishi, K.1    Takeda, S.2    Sakamoto, A.3    Kitamura, A.4
  • 27
    • 0035116137 scopus 로고    scopus 로고
    • Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury
    • Nakatani K, Takeshita S, Tsujimoto H, Kawamura Y, Sekine I. 2001. Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury. J Leukoc Biol 69:241-7.
    • (2001) J Leukoc Biol , vol.69 , pp. 241-247
    • Nakatani, K.1    Takeshita, S.2    Tsujimoto, H.3    Kawamura, Y.4    Sekine, I.5
  • 28
    • 33750930850 scopus 로고    scopus 로고
    • Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha
    • Ren B, Wu H, Zhu J, et al. 2006. Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha. Transplant Proc 38:2777-9.
    • (2006) Transplant Proc , vol.38 , pp. 2777-2779
    • Ren, B.1    Wu, H.2    Zhu, J.3
  • 29
    • 84993804695 scopus 로고    scopus 로고
    • The systemic inflammatory response syndrome following cardiac surgery: Different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions
    • Sablotzki A, Friedrich I, Mühling J, et al. 2002. The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions. Perfusion 17:103-9.
    • (2002) Perfusion , vol.17 , pp. 103-109
    • Sablotzki, A.1    Friedrich, I.2    Mühling, J.3
  • 31
    • 0034219017 scopus 로고    scopus 로고
    • Induction of acute-phase reactive substances during open-heart surgery and efficacy of ulinastatin. Inhibiting cytokines and postoperative organ injury
    • Sato Y, Ishikawa S, Otaki A, et al. 2000. Induction of acute-phase reactive substances during open-heart surgery and efficacy of ulinastatin. Inhibiting cytokines and postoperative organ injury. Jpn J Thorac Cardiovasc Surg 48:428-34.
    • (2000) Jpn J Thorac Cardiovasc Surg , vol.48 , pp. 428-434
    • Sato, Y.1    Ishikawa, S.2    Otaki, A.3
  • 32
    • 0031284642 scopus 로고    scopus 로고
    • The effects of epislon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery
    • Slaughter TF, Faghih F, Greenberg CS, Leslie JB, Sladen RN. 1997. The effects of epislon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery. Anesth Analg 85:1221-6.
    • (1997) Anesth Analg , vol.85 , pp. 1221-1226
    • Slaughter, T.F.1    Faghih, F.2    Greenberg, C.S.3    Leslie, J.B.4    Sladen, R.N.5
  • 33
    • 0036696056 scopus 로고    scopus 로고
    • Effect of a human urinary protease inhibitor (ulinastatin) on respiratory function in pediatric patients undergoing cardiopulmonary bypass
    • Sugita T, Watarida S, Katsuyama K, Nakajima Y, Yamamoto R, Mori A. 2002. Effect of a human urinary protease inhibitor (Ulinastatin) on respiratory function in pediatric patients undergoing cardiopulmonary bypass. J Cardiovasc Surg 43:437-40.
    • (2002) J Cardiovasc Surg , vol.43 , pp. 437-440
    • Sugita, T.1    Watarida, S.2    Katsuyama, K.3    Nakajima, Y.4    Yamamoto, R.5    Mori, A.6
  • 34
    • 15244355510 scopus 로고    scopus 로고
    • Relationship between race and mortality and morbidity after valve replacement surgery
    • Taylor NE, O'Brien S, Edwards FH, Peterson ED, Bridges CR. 2005. Relationship between race and mortality and morbidity after valve replacement surgery. Circulation 111:1305-12.
    • (2005) Circulation , vol.111 , pp. 1305-1312
    • Taylor, N.E.1    O'Brien, S.2    Edwards, F.H.3    Peterson, E.D.4    Bridges, C.R.5
  • 35
    • 0030818330 scopus 로고    scopus 로고
    • Inflammatory response to cardiopulmonary bypass: Mechanisms involved and possible therapeutic strategies
    • Wan S, LeClerc JL, Vincent JL. 1997. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112: 676-92.
    • (1997) Chest , vol.112 , pp. 676-692
    • Wan, S.1    LeClerc, J.L.2    Vincent, J.L.3


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