A human urinary protease inhibitor (ulinastatin) inhibits neutrophil extracellular release of elastase during cardiopulmonary bypass

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 11, Issue 5, 1997, Pages 580-584

  Hiyama, Atsuko ^a   Takeda, Junzo ^a   Kotake, Yoshifumi ^a   Morisaki, Hiroshi ^a   Fukushima, Kazuaki ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Cardiopulmonary bypass; Elastase; Neutrophil; Protease inhibitor; Ulinastatin

Indexed keywords

ELASTASE; ULINASTATIN;

ADULT; ARTICLE; ATELECTASIS; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME RELEASE; EXTRACELLULAR MATRIX; GAS EXCHANGE; HUMAN; LUNG DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURGICAL PATIENT;

EID: 0030769416     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-0770(97)90008-2     Document Type: Article

References (24)

1. Gillinov AM, Redmond JM, Winkelstein JA, et al: Complement and neutrophil activation during cardiopulmonary bypass: A study in the complement-deficient dog. Ann Thorac Surg 57:345-352, 1994
2. Gillinov AM, Redmond JM, Zehr KJ, et al: Inhibition of neutrophil adhesion during cardiopulmonary bypass. Ann Thorac Surg 57:126-133, 1994
3. Tonz M, Mihaljevic T, von-Segesser LK, et al: Acute lung injury during cardiopulmonary bypass: Are the neutrophils responsible? Chest 108:1551-1556, 1995
4. Butler J, Parker D, Pillai R, et al: Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor. J Thorac Cardiovasc Surg 105:25-30, 1993
5. Stahl RF, Fisher CA, Kucich U, et al: Effects of simulated extracorporeal circulation on human leukocyte elastase release, superoxide generation, and procoagulant activity. J Thorac Cardiovasc Surg 101:230-239, 1991
6. Smith RJ, Speziale SC, Sam LM, et al: Requirement for cell-bound proteases in the mechanisms of human neutrophil activation with various stimuli. Inflammation 10:257-270, 1986
7. Kantorski J, Tchorzewski H: The effect of serine and thiol protease inhibitors on the chemiluminescence of human neutrophils in investigations in vitro. J Biolumin Chemilumin 7:37-45, 1992
8. Horiguchi T, Harada Y: The effect of protease inhibitor on reperfusion injury after unilateral pulmonary ischemia. Transplantation 55:254-258, 1993
9. Endo S, Inada K, Yamashita H, et al: The inhibitory actions of protease inhibitors on the production of polymorphonuclear leukocyte elastase and interleukin-8. Res Commun Chem Pathol Pharmacol 82:27-34, 1993
10. Enzan K, Mitsuhata H, Masaki Y, et al: Effects of ulinastatin on granulocyte elastase and fibronectin in patients undergoing cardiopulmonary bypass. Masui (Jpn) 40:1625-1631, 1991
11. Doi H, Andoh T, Okutsu Y: Effects of ulinastatin on the serum activities of granulocyte elastase, β-glucuronidase and pancreatic secretory trypsin inhibitor in patients having open cardiac surgery. Masui (Jpn) 37:975-980, 1988
12. Kramps JA, van Twisk CH, van der Linden AC: L-Pyroglutamyl-1-prolyl-1-valine-p-nitroanilide, a highly specific substrate for granulocyte elastase. Scand J Clin Lab Invest 43:427-432, 1983
13. Butler J, Rocker GM, Westaby S: Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 55:552-559, 1993
14. Royston DR, Fleming JS, Desai JB, et al: Increased production of peroxidation products associated with cardiac operations: Evidence for free radical generation. J Thorac Cardiovasc Surg 91:759-766, 1986
15. Dreyer WJ, Michael LH, Millman EE, et al: Neutrophil sequestration and pulmonary dysfunction in a canine model of open heart surgery with cardiopulmonary bypass: Evidence for a CD18-dependent mechanism. Circulation 92:2276-2283, 1995
16. Welbourn CRB, Goldman G, Paterson IS, et al: Neutrophil elastase and oxygen radicals: Synergism in lung injury after hindlimb ischemia. Am J Physiol 260:H1852-H1856, 1991
17. Nishijima J, Hiraoka N, Murata A, et al: Protease inhibitors (gabexate mesylate and ulinastatin) stimulate intracellular chemiluminescence in human neutrophils. J Leukoc Biol 52:262-268, 1992
18. Finn A, Naik S, Klein N, et al: Interleukin-8 release and neutrophil degranulation after pediatric cardiopulmonary bypass. J Thorac Cardiovasc Surg 105:234-241, 1993
19. Kawamura T, Wakusawa R, Okada K, Inada S: Elevation of cytokines during open heart surgery with cardiopulmonary bypass: Participation of interleukin 8 and 6 in reperfusion injury. Can J Anaesth 40:1016-1021, 1993
20. Jansen NJ, van-Oeveren W, van-Vliet M, et al: The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass. Eur J Cardiothorac Surg 5:211-217, 1991
21. Hill GE, Alonso A, Spurzem JR, et al: Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans. J Thorac Cardiovasc Surg 110:1658-1662, 1995
22. 4-induced hyperadhesiveness of endothelial cells for neutrophils: Relation to CD54. Clin Exp Immunol 90:300-304, 1992
23. 2+. Proc Natl Acad Sci USA 87:9472-9476, 1990
24. Shappell SB, Toman C, Anderson DC, et al: Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J Immunol 144:2702-2711, 1990