Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

Oncotarget

Volumn 5, Issue 22, 2014, Pages 11501-11512

  Jeannette, Boutter ^a   Huang, Yun ^a   Marovca, Blerim ^a   Vonderheit, Andreas ^b   Grotzer, Michael A ^a   Eckert, Cornelia ^c   Cario, Gunnar ^d   Wollscheid, Bernd ^e   Horvath, Peter ^f,g   Bornhauser, Beat C ^a   Bourquin, Jean Pierre ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Armenia)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e ETH ZURICH   (Switzerland)

^f INSTITUTE OF BIOCHEMISTRY   (Hungary)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

acute lymphoblastic leukemia; bone marrow stroma; microenvironment; oxidative stress; RNAi screen

Indexed keywords

AMINO ACID TRANSPORTER; CARRIER PROTEINS AND BINDING PROTEINS; CYSTEINE; CYSTEINE DIOXYGENASE; CYSTINE TRANSPORTER XC; GLUTATHIONE; SOLUTE CARRIER FAMILY 3 MEMBER 2; SOLUTE CARRIER FAMILY 7 MEMBER 11; UNCLASSIFIED DRUG; CD98 ANTIGEN; CYTOKINE; REACTIVE OXYGEN METABOLITE; SLC3A2 PROTEIN, HUMAN; SLC7A11 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE MARROW STROMA CELL; CANCER GROWTH; CANCER SURVIVAL; CELL DEATH; CELL INTERACTION; CELL METABOLISM; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMAGING AND DISPLAY; LIVE CELL IMAGING BASED RNA INTERFERENCE; MICROENVIRONMENT; OXIDATIVE STRESS; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA INTERFERENCE; BONE MARROW; BONE MARROW CELL; COCULTURE; CYTOLOGY; DISEASE COURSE; GENE EXPRESSION REGULATION; LEUKEMIA; MESENCHYMAL STROMA CELL; METABOLISM; STROMA CELL;

AMINO ACID TRANSPORT SYSTEM Y+; ANTIGENS, CD98 HEAVY CHAIN; BONE MARROW; BONE MARROW CELLS; CELL DEATH; CELL SURVIVAL; COCULTURE TECHNIQUES; CYSTEINE; CYTOKINES; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA; MESENCHYMAL STROMAL CELLS; OXIDATIVE STRESS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; STROMAL CELLS;

EID: 84917706093     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: None     Document Type: Article

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