The haematopoietic stem cell niche at a glance

Journal of Cell Science

Volumn 124, Issue 21, 2011, Pages 3529-3535

  Celso, Cristina Lo ^a   Scadden, David T ^b,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c Harvard University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; CALCIUM; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CXCR4; NOTCH RECEPTOR; OXYGEN; SONIC HEDGEHOG PROTEIN; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; WNT PROTEIN;

ARTICLE; CELL FATE; CELL FUNCTION; CELL MIGRATION; CELLS AND CELL COMPONENTS; EXTRACELLULAR MATRIX; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOMEOSTASIS; HUMAN; MYELODYSPLASTIC SYNDROME; MYELOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION; STEM CELL NICHE;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; SIGNAL TRANSDUCTION;

EID: 81355147381     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.074112     Document Type: Article

References (63)

1. Adams, G. B., Chabner, K. T., Alley, I. R., Olson, D. P., Szczepiorkowski, Z. M., Poznansky, M. C., Kos, C. H., Pollak, M. R., Brown, E. M. and Scadden, D. T. (2006). Stem cell engraftment at the' endosteal niche is specified by the calcium-sensing receptor. Nature 439, 599-603.
2. Adams, G. B., Alley, I. R., Chung, U. I., Chabner, K. T., Jeanson, N. T., Lo Celso, C., Marsters, E. S., Chen, M., Weinstein, L. S., Lin, C. P. et al. (2009). Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature 459, 103-107.
3. Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y. and Suda, T. (2004). Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161.
4. Barker, J. E. (1997). Early transplantation to a normal microenvironment prevents the development of Steel hematopoietic stem cell defects. Exp. Hematol. 25, 542-547.
5. Bhardwaj, G., Murdoch, B., Wu, D., Baker, D. P., Williams, K. P., Chadwick, K., Ling, L. E., Karanu, F. N. and Bhatia, M. (2001). Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2, 172-180.
6. Bhattacharya, D., Czechowicz, A., Ooi, A. G., Rossi, D. J., Bryder, D. and Weissman, I. L. (2009). Niche recycling through division-independent egress of hematopoietic stem cells. J. Exp. Med. 206, 2837-2850.
7. Bonig, H., Chudziak, D., Priestley, G. and Papayannopoulou, T. (2009). Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100. Exp. Hematol. 37, 402-415 e1.
8. Brouard, N., Driessen, R., Short, B. and Simmons, P. J. (2010). G-CSF increases mesenchymal precursor cell numbers in the bone marrow via an indirect mechanism involving osteoclast-mediated bone resorption. Stem Cell Res. 5, 65-75.
9. Butler, J. M., Nolan, D. J., Vertes, E. L., Varnum-Finney, B., Kobayashi, H., Hooper, A. T., Seandel, M., Shido, K., White, I. A., Kobayashi, M. et al. (2010). Endothelial cells are essential for the self-renewal and repopulation of Notchdependent hematopoietic stem cells. Cell Stem Cell 6, 251-264.
10. Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Divieti, P., Bringhurst, F. R. et al. (2003). Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846.
11. Cobas, M., Wilson, A., Ernst, B., Mancini, S. J., MacDonald, H. R., Kemler, R. and Radtke, F. (2004). Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J. Exp. Med. 199, 221-229.
12. Colmone, A., Amorim, M., Pontier, A. L., Wang, S., Jablonski, E. and Sipkins, D. A. (2008). Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science 322, 1861-1865.
13. Connelly, J. T., Gautrot, J. E., Trappmann, B., Tan, D. W., Donati, G., Huck, W. T. and Watt, F. M. (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat. Cell Biol. 12, 711-718.
14. Corral, D. A., Amling, M., Priemel, M., Loyer, E., Fuchs, S., Ducy, P., Baron, R. and Karsenty, G. (1998). Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc. Natl. Acad. Sci. USA 95, 13835-13840.
15. Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N. et al. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat. Immunol. 6, 314-322.
16. Dykstra, B., Kent, D., Bowie, M., McCaffrey, L., Hamilton, M., Lyons, K., Lee, S., Brinkman, R. and Eaves, C. (2007). Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1, 218-229.
17. Essers, M. A., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A. and Trumpp, A. (2009). IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 458, 904-908.
18. Fleming, H. E., Janzen, V., Guo, J., Celso, C. L., Leahy, K. M., Kronenberg, H. M. and Scadden, D. T. (2008). Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2, 274-283.
19. Fujisaki, J., Wu, J., Carlson, A. L., Silberstein, L., Putheti, P., Gao, W., Saito, T., Lo Celso, C., Tsuyuzaki, H., Sato, T. et al. (2011). In vivo imaging of Tregs providing immune privilege to the hematopoietic stem cell niche. Nature 474, 216-219.
20. Goessling, W., North, T. E., Loewer, S., Lord, A. M., Lee, S., Stoick-Cooper, C. L., Weidinger, G., Puder, M., Daley, G. Q., Moon, R. T. et al. (2009). Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136, 1136-1147.
21. Goldman, D. C., Bailey, A. S., Pfaffle, D. L., Al Masri, A., Christian, J. L. and Fleming, W. H. (2009). BMP4 regulates the hematopoietic stem cell niche. Blood 114, 4393-4401.
22. Goodell, M. A. (2005). Stem cell identification and sorting using the Hoechst 33342 side population (SP). Curr. Protoc. Cytom. Chapter 9, Unit9 18.
23. Grassinger, J., Haylock, D. N., Williams, B., Olsen, G. H. and Nilsson, S. K. (2010). Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential. Blood 116, 3185-3196.
24. Haylock, D. N. and Nilsson, S. K. (2006). The role of hyaluronic acid in hemopoietic stem cell biology. Regen. Med. 1, 437-445.
25. Hofmann, I., Stover, E. H., Cullen, D. E., Mao, J., Morgan, K. J., Lee, B. H., Kharas, M. G., Miller, P. G., Cornejo, M. G., Okabe, R. et al. (2009). Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 4, 559-567.
26. Hooper, A. T., Butler, J. M., Nolan, D. J., Kranz, A., Iida, K., Kobayashi, M., Kopp, H. G., Shido, K., Petit, I., Yanger, K. et al. (2009). Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell 4, 263-274.
27. Jiang, S., Zagozdzon, R., Jorda, M. A., Parmar, K., Fu, Y., Williams, J. S., Wood, J. A., Makriyannis, A., Banu, N., Avraham, S. et al. (2010). Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. J. Biol. Chem. 285, 35471-35478.
28. Jiang, S., Alberich-Jorda, M., Zagozdzon, R., Parmar, K., Fu, Y., Mauch, P., Banu, N., Makriyannis, A., Tenen, D. G., Avraham, S. et al. (2011). Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 117, 827-838.
29. Jiang, Y., Bonig, H., Ulyanova, T., Chang, K. and Papayannopoulou, T. (2009). On the adaptation of endosteal stem cell niche function in response to stress. Blood. 114, 3773-3782.
30. Jung, Y., Wang, J., Schneider, A., Sun, Y. X., Koh-Paige, A. J., Osman, N. I., McCauley, L. K. and Taichman, R. S. (2006). Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone 38, 497-508.
31. Katayama, Y., Battista, M., Kao, W. M., Hidalgo, A., Peired, A. J., Thomas, S. A. and Frenette, P. S. (2006). Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124, 407-421.
32. Kiel, M. J., Yilmaz, O. H., Iwashita, T., Yilmaz, O. H., Terhorst, C. and Morrison, S. J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121.
33. Kieslinger, M., Hiechinger, S., Dobreva, G., Consalez, G. G. and Grosschedl, R. (2010). Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cellnonautonomous manner. Cell Stem Cell 7, 496-507.
34. Kirstetter, P., Anderson, K., Porse, B. T., Jacobsen, S. E. and Nerlov, C. (2006). Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat. Immunol. 7, 1048-1056.
35. Kobayashi, H., Butler, J. M., O'Donnell, R., Kobayashi, M., Ding, B. S., Bonner, B., Chiu, V. K., Nolan, D. J., Shido, K., Benjamin, L. et al. (2010). Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat. Cell Biol. 12, 1046-1056.
36. Koch, U., Wilson, A., Cobas, M., Kemler, R., Macdonald, H. R. and Radtke, F. (2008). Simultaneous loss of betaand gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood 111, 160-164.
37. Kohler, A., Schmithorst, V., Filippi, M. D., Ryan, M. A., Daria, D., Gunzer, M. and Geiger, H. (2009). Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood 114, 290-298.
38. Kollet, O., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R. M., Goichberg, P., Spiegel, A. et al. (2006). Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat. Med. 12, 657-664.
39. Kurth, I., Franke, K., Pompe, T., Bornhauser, M. and Werner, C. (2009). Hematopoietic stem and progenitor cells in adhesive microcavities. Integr. Biol. (Camb) 1, 427-434.
40. Lane, S. W., Scadden, D. T. and Gilliland, D. G. (2009). The leukemic stem cell niche-current concepts and therapeutic opportunities. Blood 114, 1150-1157.
41. Levesque, J. P., Winkler, I. G., Hendy, J., Williams, B., Helwani, F., Barbier, V., Nowlan, B. and Nilsson, S. K. (2007). Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells 25, 1954-1965.
42. Levesque, J. P., Helwani, F. M. and Winkler, I. G. (2010). The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia 24, 1979-1992.
43. Lewandowski, D., Barroca, V., Duconge, F., Bayer, J., Van Nhieu, J. T., Pestourie, C., Fouchet, P., Tavitian, B. and Romeo, P. H. (2010). In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution. Blood 115, 443-452.
44. Lo Celso, C., Fleming, H. E., Wu, J. W., Zhao, C. X., Miake-Lye, S., Fujisaki, J., Cote, D., Rowe, D. W., Lin, C. P. and Scadden, D. T. (2009). Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature 457, 92-96.
45. Lo Celso, C., Lin, C. P. and Scadden, D. T. (2011). In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow. Nat. Protoc. 6, 1-14.
46. Lord, B. I., Testa, N. G. and Hendry, J. H. (1975). The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood 46, 65-72.
47. Lymperi, S., Ersek, A., Ferraro, F., Dazzi, F. and Horwood, N. J. (2011). Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood 117, 1540-1549.
48. Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F. et al. (2008). Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2, 356-366.
49. Malhotra, S. and Kincade, P. W. (2009a). Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells. Exp. Hematol. 37, 19-30.
50. Malhotra, S. and Kincade, P. W. (2009b). Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell 4, 27-36.
51. Mancini, S. J., Mantei, N., Dumortier, A., Suter, U., MacDonald, H. R. and Radtke, F. (2005). Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105, 2340-2342.
52. Mayack, S. R. and Wagers, A. J. (2008). Osteolineage niche cells initiate hematopoietic stem cell mobilization. Blood 112, 519-531.
53. Mendez-Ferrer, S., Lucas, D., Battista, M. and Frenette, P. S. (2008). Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452, 442-447.
54. Mendez-Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., Macarthur, B. D., Lira, S. A., Scadden, D. T., Ma'ayan, A., Enikolopov, G. N. and Frenette, P. S. (2010). Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466, 829-834.
55. Migliaccio, A. R., Carta, C. and Migliaccio, G. (1999). In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice. Exp. Hematol. 27, 1655-1666.
56. Morikawa, S., Mabuchi, Y., Kubota, Y., Nagai, Y., Niibe, K., Hiratsu, E., Suzuki, S., Miyauchi-Hara, C., Nagoshi, N., Sunabori, T. et al. (2009). Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J. Exp. Med. 206, 2483-2496.
57. Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N. and Hirao, A. (2010). TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463, 676-680.
58. Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. and Suda, T. (2010). Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood 116, 1422-1432.
59. Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F. and Daley, G. Q. (2009). Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460, 259-263.
60. Nielsen, J. S. and McNagny, K. M. (2007). Influence of host irradiation on long-term engraftment by CD34-deficient hematopoietic stem cells. Blood 110, 1076-1077.
61. Nilsson, S. K., Johnston, H. M., Whitty, G. A., Williams, B., Webb, R. J., Denhardt, D. T., Bertoncello, I., Bendall, L. J., Simmons, P. J. and Haylock, D. N. (2005). Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood 106, 1232-1239.
62. North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Grosser, T. et al. (2007). Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447, 1007-1011.
63. Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R. and Down, J. D. (2007). Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl. Acad. Sci. USA 104, 5431-5436.